Hoatlin: Fundamentals: Difference between revisions
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==Questions and Answers== | ==Questions and Answers== | ||
*Taken from emailed questions: | *Taken from emailed questions: | ||
;Question | |||
"alternative protein processing"? | *What is the difference between "alternative RNA Processing" and "alternative protein processing"? | ||
Alternative RNA processing is exhibited in the example of | ;Answer | ||
*Alternative RNA processing is exhibited in the example of | |||
calcitonin and calcitonin gene related peptide. The same transcript is | calcitonin and calcitonin gene related peptide. The same transcript is | ||
spliced | spliced in different ways to achieve different mRNAs and thus alternative proteins. | ||
in different ways to achieve different mRNAs and thus alternative proteins. | |||
Alternative protein processing can refer to a number of things | *Alternative protein processing can refer to a number of things. Rather than confuse the | ||
issue with examples, Let me know where the statement was in the notes so I can clarify. | |||
issue with examples, Let me know where the statement was in the notes so I | |||
can clarify. | |||
;Question | |||
*Can you shed some light on what is important about SINEs and LINEs, | |||
other than being | other than being transposons? | ||
transposons? | ;Answer | ||
LINEs and SINEs are important to know about because (1) they | *LINEs and SINEs are important to know about because (1) they | ||
provide knowledge about a large part of the human genome (2) the role of | provide knowledge about a large part of the human genome (2) the role of | ||
SINEs | SINEs and LINEs in genome evolution (e.g., via recombination) and (3) it is | ||
and LINEs in genome evolution (e.g., via recombination) and (3) it is | likely that a clearer picture of the activities of LINEs and SINEs in genomic | ||
likely | |||
that a clearer picture of the activities of LINEs and SINEs in genomic | |||
stability and clinically-important influences will continue to emerge (see | stability and clinically-important influences will continue to emerge (see | ||
abstract for a recent review: http://www.ncbi.nlm.nih.gov/pubmed/20307669). | abstract for a recent review: http://www.ncbi.nlm.nih.gov/pubmed/20307669). |
Revision as of 20:17, 22 January 2012
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Really.
Questions and Answers
calcitonin and calcitonin gene related peptide. The same transcript is spliced in different ways to achieve different mRNAs and thus alternative proteins.
issue with examples, Let me know where the statement was in the notes so I can clarify.
other than being transposons?
provide knowledge about a large part of the human genome (2) the role of SINEs and LINEs in genome evolution (e.g., via recombination) and (3) it is likely that a clearer picture of the activities of LINEs and SINEs in genomic stability and clinically-important influences will continue to emerge (see abstract for a recent review: http://www.ncbi.nlm.nih.gov/pubmed/20307669).
That's how PARP1 inhibitors are relatively selective in killing the HR deficient tumor cell but not the wild-type cell (which is competent for HR)
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