Hoatlin Lab: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
(7 intermediate revisions by the same user not shown)
Line 13: Line 13:


We work in [[Hoatlin:Portland Oregon| Portland, Oregon]] at [http://www.ohsu.edu/ OHSU], in the [http://www.ohsu.edu/biochem/ Department of Biochemistry & Molecular Biology] and the [http://www.ohsucancer.com/ OHSU Knight Cancer Institute].  
We work in [[Hoatlin:Portland Oregon| Portland, Oregon]] at [http://www.ohsu.edu/ OHSU], in the [http://www.ohsu.edu/biochem/ Department of Biochemistry & Molecular Biology] and the [http://www.ohsucancer.com/ OHSU Knight Cancer Institute].  
==Bio for Maureen Hoatlin==
Maureen Hoatlin is an Associate Professor of Biochemistry & Molecular Biology, and Molecular & Medical Genetics at Oregon Health & Science University (OHSU).  After earning a B.S. degree in Chemistry from Old Dominion University, she was a project chemist at SRI International in Menlo Park, CA for two years, followed by six years as a research associate at Genentech, Inc. She received a Ph.D. at Oregon Health & Science University for graduate work focusing on the role of retroviruses in pathogenesis and hematopoietic cancers.  She joined the faculty in Hematology & Medical Oncology at OHSU in 1993, and was a Visiting Scientist & Professor in the Department of Genetics at the Free University and Medical Center of Amsterdam in 1998 and in 2002.  Dr. Hoatlin’s research is focused on identifying and analyzing the function of the proteins in the Fanconi Anemia/Breast Cancer (FA/BRCA) cancer susceptibility pathway.  Her work has contributed to the discovery and characterization of ten novel human genes, many with critical but poorly understood roles in hematopoiesis, cancer susceptibility (AML and other cancers), and resistance to certain commonly-used chemotherapeutic drugs. Dr. Hoatlin’s lab pioneered a cell-free approach to analyze the function of the FA/BRCA pathway and recently received a patent for a novel small molecule inhibitor screen for identification of FA/BRCA pathway inhibitors and potential chemosensitizing compounds.
Dr. Hoatlin has recently completed an MBA with a specialty on international business in Asia, as well a specialized UCSF course (ACDRS) on the drug development pipeline that focuses on preparation for future developments and changes in the global pharmaceutical sector. Dr. Hoatlin is a member of the strategic planning leadership for OHSU’s School of Medicine, the Hematologic Malignancies Program, advisory board member of the Oregon Translational Research and Development Institute, and founding co-chair of the OHSU Rare Disease Consortium. Dr. Hoatlin is interested in developing industry-academic partnerships aimed at using rare disease research to de-risk drug development.


==Teaching Links==
==Teaching Links==


*Our lab's Fanconi Anemia antibodies are available from [http://www.novusbio.com Novus Biologicals] and soon by Millipore.
*Our lab's Fanconi Anemia antibodies are available from [http://www.novusbio.com Novus Biologicals] and by Millipore.


[http://openwetware.org/wiki/CANB_610 Advanced Topics in Cancer Biology (CANB 610)]
[http://openwetware.org/wiki/CANB_610 Advanced Topics in Cancer Biology (CANB 610)]
Line 24: Line 30:
[[Hoatlin:OHSU Replication, Recombination and Repair (R3) Club| OHSU DNA Replication, Recombination and Repair (R3) Club]].
[[Hoatlin:OHSU Replication, Recombination and Repair (R3) Club| OHSU DNA Replication, Recombination and Repair (R3) Club]].


[[Hoatlin: CSF|Med Students Cell Structure Function (CSF)]]
[[Hoatlin: CSF|Med Students Fundamentals]]
 
==Biochemistry Seminar Series==
[http://openwetware.org/wiki/Hoatlin:BMB_seminar_series_'15-'16 Biochemistry Seminar Series Working Draft]


==Classes of the past==
==Classes of the past==

Revision as of 10:56, 18 August 2016

Equipped with his five senses, man explores the universe around him and calls the adventure Science. ~Edwin Powell Hubble, The Nature of Science, 1954

Home        Projects        Team        Papers        Contact Us        Protocols        Collaborations        News        Reagent Requests        secret back door        Hoatlin Lab Twitter       



Lab News

For news, follow the Hoatlin lab Twitter


Our laboratory is interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility. The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility. Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer.

We work in Portland, Oregon at OHSU, in the Department of Biochemistry & Molecular Biology and the OHSU Knight Cancer Institute.

Bio for Maureen Hoatlin

Maureen Hoatlin is an Associate Professor of Biochemistry & Molecular Biology, and Molecular & Medical Genetics at Oregon Health & Science University (OHSU). After earning a B.S. degree in Chemistry from Old Dominion University, she was a project chemist at SRI International in Menlo Park, CA for two years, followed by six years as a research associate at Genentech, Inc. She received a Ph.D. at Oregon Health & Science University for graduate work focusing on the role of retroviruses in pathogenesis and hematopoietic cancers. She joined the faculty in Hematology & Medical Oncology at OHSU in 1993, and was a Visiting Scientist & Professor in the Department of Genetics at the Free University and Medical Center of Amsterdam in 1998 and in 2002. Dr. Hoatlin’s research is focused on identifying and analyzing the function of the proteins in the Fanconi Anemia/Breast Cancer (FA/BRCA) cancer susceptibility pathway. Her work has contributed to the discovery and characterization of ten novel human genes, many with critical but poorly understood roles in hematopoiesis, cancer susceptibility (AML and other cancers), and resistance to certain commonly-used chemotherapeutic drugs. Dr. Hoatlin’s lab pioneered a cell-free approach to analyze the function of the FA/BRCA pathway and recently received a patent for a novel small molecule inhibitor screen for identification of FA/BRCA pathway inhibitors and potential chemosensitizing compounds.

Dr. Hoatlin has recently completed an MBA with a specialty on international business in Asia, as well a specialized UCSF course (ACDRS) on the drug development pipeline that focuses on preparation for future developments and changes in the global pharmaceutical sector. Dr. Hoatlin is a member of the strategic planning leadership for OHSU’s School of Medicine, the Hematologic Malignancies Program, advisory board member of the Oregon Translational Research and Development Institute, and founding co-chair of the OHSU Rare Disease Consortium. Dr. Hoatlin is interested in developing industry-academic partnerships aimed at using rare disease research to de-risk drug development.

Teaching Links

  • Our lab's Fanconi Anemia antibodies are available from Novus Biologicals and by Millipore.

Advanced Topics in Cancer Biology (CANB 610)

Genetic Mechanisms Class (CON662)

OHSU DNA Replication, Recombination and Repair (R3) Club.

Med Students Fundamentals

Biochemistry Seminar Series

Biochemistry Seminar Series Working Draft

Classes of the past

Advanced Topics in Molecular Biology(BMB625)

Who is Visiting Us?

Who's visiting?

<html> <a href="http://clustrmaps.com/counter/maps.php?url=http://openwetware.org/wiki/Hoatlin_Lab" id="clustrMapsLink"><img src="http://clustrmaps.com/counter/index2.php?url=http://openwetware.org/wiki/Hoatlin_Lab" border=1 alt="Locations of visitors to this page"onError="this.onError=null; this.src='http://www.meetomatic.com/images/clustrmaps-back-soon.jpg'; document.getElementById('clustrMapsLink').href='http://clustrmaps.com/'"> </a> </html>

Basic Wiki/OWW Links

<wikionly>

Recent changes
List of abbreviations:
N
This edit created a new page (also see list of new pages)
m
This is a minor edit
b
This edit was performed by a bot
(±123)
The page size changed by this number of bytes

17 April 2024

     15:34  BioMicroCenter:Element Sequencing‎‎ 3 changes history +295 [Challee‎ (3×)]
     
15:34 (cur | prev) +195 Challee talk contribs
     
14:22 (cur | prev) +100 Challee talk contribs
     
14:07 (cur | prev) 0 Challee talk contribs
     13:10  BioMicroCenter:SingleCell diffhist +30 Noelani Kamelamela talk contribs (→‎10X CHROMIUM X)
     12:43  BioMicroCenter diffhist −15 Noelani Kamelamela talk contribs

16 April 2024

N    19:59  Nanoimprint Lithography (NIL) - Carter Paul‎‎ 10 changes history +7,205 [CarterPaul‎ (10×)]
     
19:59 (cur | prev) +769 CarterPaul talk contribs (→‎Thermal NIL Process)
     
19:53 (cur | prev) 0 CarterPaul talk contribs (→‎Thermal NIL Process)
     
19:53 (cur | prev) 0 CarterPaul talk contribs (→‎Thermal NIL Process)
     
19:52 (cur | prev) +1 CarterPaul talk contribs (→‎Thermal NIL Process)
     
19:50 (cur | prev) +202 CarterPaul talk contribs (→‎Thermal NIL Process)
     
19:17 (cur | prev) −20 CarterPaul talk contribs (→‎References)
     
19:17 (cur | prev) −1 CarterPaul talk contribs
     
19:11 (cur | prev) +4,278 CarterPaul talk contribs
     
18:53 (cur | prev) +1,891 CarterPaul talk contribs
N    
18:42 (cur | prev) +85 CarterPaul talk contribs (Created page with "{{Template:CHEM-ENG590E}} =Motivation= =Introduction to NIL= =Thermal NIL Process=")
     19:40 Upload log CarterPaul talk contribs uploaded File:NIL1.png
N    18:40  3D Cell Culture - McLean Taggart, Emma Villares, Maximillian Marek, Scott LeBlanc, Adam Lyons and Jacob Belden diffhist +24,060 CarterPaul talk contribs (Created page with "{{Template:CHEM-ENG590E}} ==Introduction== While most microfluidic devices incorporate a 2D cell culture design, in which a single layer of cells is grown on the bottom of a device, these systems suffer from poor <i>in vivo</i> mimicry, as, in the human body, most cells grow in all directions.<sup>https://doi.org/10.5114/aoms.2016.63743 1</sup> To address this limitation, 3D cell culture devices have been developed - in w...")
     18:38  CHEM-ENG590E:Wiki Textbook‎‎ 2 changes history +63 [CarterPaul‎ (2×)]
     
18:38 (cur | prev) +50 CarterPaul talk contribs (→‎Chapter 1 - Microfabrication)
     
18:37 (cur | prev) +13 CarterPaul talk contribs
     18:36  3D Cell Culture - McLean Taggart, Emma Villares, Maximillian Marek, Scott LeBlanc, and Adam Lyons diffhist +5,343 CarterPaul talk contribs (Added a Technique and applications section)
     10:20  Yarn Microfluidics - Roger Dirth‎‎ 12 changes history +442 [Rcostello‎ (12×)]
     
10:20 (cur | prev) +41 Rcostello talk contribs (→‎Applications)
     
10:19 (cur | prev) +36 Rcostello talk contribs (→‎Applications)
     
10:18 (cur | prev) +36 Rcostello talk contribs (→‎Introduction)
     
10:17 (cur | prev) +38 Rcostello talk contribs (→‎Fabrication)
     
10:17 (cur | prev) +38 Rcostello talk contribs (→‎Washburn Equation)
     
10:16 (cur | prev) +38 Rcostello talk contribs (→‎Wicking Rate)
     
10:16 (cur | prev) +37 Rcostello talk contribs (→‎Introduction)
     
10:15 (cur | prev) +36 Rcostello talk contribs (→‎Wicking Rate)
     
10:14 (cur | prev) +36 Rcostello talk contribs (→‎Fabrication)
     
10:14 (cur | prev) +34 Rcostello talk contribs (→‎Applications)
     
10:14 (cur | prev) +36 Rcostello talk contribs (→‎Introduction)
     
10:13 (cur | prev) +36 Rcostello talk contribs (→‎Introduction)
     08:18  3D Printed Microfluidic Robots - Helen Hua‎‎ 2 changes history +6 [Michele Caggioni‎ (2×)]
     
08:18 (cur | prev) +22 Michele Caggioni talk contribs (→‎Actuation)
     
08:18 (cur | prev) −16 Michele Caggioni talk contribs (→‎Actuation)
     08:11  3D Printing Overview diffhist +422 Michele Caggioni talk contribs

15 April 2024

     23:43  User:Yanbin Huang‎‎ 2 changes history +170 [Yanbin Huang‎ (2×)]
     
23:43 (cur | prev) 0 Yanbin Huang talk contribs (→‎Granted Patents)
     
23:43 (cur | prev) +170 Yanbin Huang talk contribs (→‎Granted Patents)
     22:11  The paper that launched microfluidics - Xi Ning‎‎ 11 changes history +4,793 [Xning098‎ (11×)]
     
22:11 (cur | prev) −6 Xning098 talk contribs (→‎Summary)
     
22:07 (cur | prev) −12 Xning098 talk contribs (→‎Synthesis)
     
22:06 (cur | prev) 0 Xning098 talk contribs
     
22:06 (cur | prev) +1 Xning098 talk contribs
     
22:05 (cur | prev) 0 Xning098 talk contribs
     
22:03 (cur | prev) +630 Xning098 talk contribs
     
22:01 (cur | prev) +3,189 Xning098 talk contribs
     
21:44 (cur | prev) +688 Xning098 talk contribs (→‎Separation and quantification)
     
21:33 (cur | prev) +306 Xning098 talk contribs
     
21:29 (cur | prev) −2 Xning098 talk contribs (→‎Electrokinetic effect)
     
21:28 (cur | prev) −1 Xning098 talk contribs (→‎Separation and quantification)
     21:45  (Upload log) [Xning098‎ (2×)]
     
21:45 Xning098 talk contribs uploaded File:Figure 4 Tdesign.png
     
21:30 Xning098 talk contribs uploaded File:Figure 3 Set-up3.png

</wikionly>