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In their ‘ON’ state, in the absence of attractants, several receptors bind to CheA in such a way that CheA is activated over 100-fold [24], and conversely CheA binding to the receptors appears to be required for long-range structural interactions that serve to organize the array. In the ‘OFF’ state, in the presence of attractants, it is as if the CheA dimer is torn apart by binding to the receptor network. | |||
In E. coli, at least five different receptors — Tar, Tsr, Tap, Trg and Aer — appear to be intermingled within the same complex. | |||
a) Tar: aspartate and maltose; cobalt and nickel | |||
b) Tsr: serine | |||
c) Trg: ribose and galactose | |||
a. CheA is a kinase that takes a phosphate off of ATP and attaches it to itself | |||
b. CheW connects CheA to the chemoreceptor |
Revision as of 10:56, 5 June 2007
Bacterial signal transduction network in a genomic perspective
author: Michael Y. Galperin
Tables 1 and 2 show what types of signalling molecules are present in different types of prokaryotes.
It looks like S_TKc (Serine-Threonine kinase, catalytic) would work best for E. Coli because there are not many of them in E. Coli naturally. Or, we may want to use a signalling protein that doesn't exist yet in E. Coli, to prevent confusion and false signals.
Signal transduction: Hair brains in bacterial chemotaxis
authors: Jeff Stock and Mikhail Levit
In their ‘ON’ state, in the absence of attractants, several receptors bind to CheA in such a way that CheA is activated over 100-fold [24], and conversely CheA binding to the receptors appears to be required for long-range structural interactions that serve to organize the array. In the ‘OFF’ state, in the presence of attractants, it is as if the CheA dimer is torn apart by binding to the receptor network.
In E. coli, at least five different receptors — Tar, Tsr, Tap, Trg and Aer — appear to be intermingled within the same complex.
a) Tar: aspartate and maltose; cobalt and nickel b) Tsr: serine c) Trg: ribose and galactose
a. CheA is a kinase that takes a phosphate off of ATP and attaches it to itself b. CheW connects CheA to the chemoreceptor