IGEM:Caltech/2008/Notes

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iGEM 2008

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4.14.08: Previous projects Project Wiki Presenter Presentation 2007 UCSF Wiki Unassigned 2007 Paris Wiki Doug Paris 2007 2007 Peking Wiki Allen Peking 2007 2007 Caltech Wiki Unassigned 2006 MIT Wiki Robert MIT 2006‎ 2006 UCSF Wiki Unassigned 2006 Berkeley Wiki Fei Berkeley 2006 2006 UT-Austin Wiki Victoria UT-Austin 2006 I'd be willing to also look over USCF if we need to cover all the presentations. - Allem I would also be willing to team up with Allen to present UCSF's 2007 Presentation if it's OK with everyone. - Robert In regard to the latest email, I'll just do Peking's ppt. -Allen 4.24.08 Papers: Presenter Paper Presentation Allen Construction of a genetic toggle switch in E. coli Toggle Switch Doug Dispersing biofilms with engineered enzymatic bacteriophage Destroying Biofilms Fei A synthetic gene-metabolic oscillator. Nature 2005 May 5; 435(7038) 118-22. Media:A synthetic Gene-Metabolic Oscillator.ppt Robert Environmentally controlled invasion of cancer cells by engineered bacteria. Invasion of Cancer Cells Victoria Programmed Population Control by Cell-Cell Communication and Regulated Killing Programmed Population Control 5.1.08 Josh: Sample Presentation #1 Chase: Sample Presentation #2 5.8.08 An incomplete list of project ideas is below. Pick one, or add your own. Bactofood (food supplement) Mouthwash (and/or deodorant) Gut flora engineering CO2 mineralization Healthbots (patrolling the blood stream) Remember, describe the 'big picture' idea, then try to break it down into smaller projects. First look at large pieces - what kinds of abilities would you need (bind to X, produce Y, destroy Z) to accomplish the big picture? Next, think about how you'd produce those abilities (protein α will bind to X, pathway β would produce Y, etc). Bonus points if you can break it down into five separate mini-projects. More bonus points if things would still work with less-than-total success (we need A and B to work to declare success, but C and D would make it cooler. E would be awesome and interesting even if nothing else worked). Presenter Project Idea Presentation Allen Varied State Expressions State Exp Doug Healthbots Healthbots Fei Gut Flora engineering Media:Engineering_Gut_Microbiota.ppt Robert Mouthwash Mouthwash! Victoria CO2 mineralization CO2 Mineralization 5.15.08 Ideas: Mouthwash Bioremediation Gut flora Diabetes Allen: Doug: Artificial White Blood Cells Fei: Gut Flora Robert: Mouthwash: A Closer Look at Biofilms Victoria: Bioremediation 6.5.08 Presenter Presentation Allen Pop var Doug ROS Fei Robert Victoria Background reading Background notes Background slides Design notes Further suggested reading: Elowitz MB and Leibler S. A synthetic oscillatory network of transcriptional regulators. Nature. 2000 Jan 20;403(6767):335-8. DOI:10.1038/35002125 | Gardner TS, Cantor CR, and Collins JJ. Construction of a genetic toggle switch in Escherichia coli. Nature. 2000 Jan 20;403(6767):339-42. DOI:10.1038/35002131 | Adventures in Synthetic Biology Fung E, Wong WW, Suen JK, Bulter T, Lee SG, and Liao JC. A synthetic gene-metabolic oscillator. Nature. 2005 May 5;435(7038):118-22. DOI:10.1038/nature03508 | Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J, Chang MC, Withers ST, Shiba Y, Sarpong R, and Keasling JD. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature. 2006 Apr 13;440(7086):940-3. DOI:10.1038/nature04640 | Anderson JC, Clarke EJ, Arkin AP, and Voigt CA. Environmentally controlled invasion of cancer cells by engineered bacteria. J Mol Biol. 2006 Jan 27;355(4):619-27. DOI:10.1016/j.jmb.2005.10.076 | You L, Cox RS 3rd, Weiss R, and Arnold FH. Programmed population control by cell-cell communication and regulated killing. Nature. 2004 Apr 22;428(6985):868-71. DOI:10.1038/nature02491 | Endy D. Foundations for engineering biology. Nature. 2005 Nov 24;438(7067):449-53. DOI:10.1038/nature04342 | Voigt CA. Genetic parts to program bacteria. Curr Opin Biotechnol. 2006 Oct;17(5):548-57. DOI:10.1016/j.copbio.2006.09.001 | Andrianantoandro E, Basu S, Karig DK, and Weiss R. Synthetic biology: new engineering rules for an emerging discipline. Mol Syst Biol. 2006;2:2006.0028. DOI:10.1038/msb4100073 |