IGEM:Harvard/2006/DNA nanostructures

From OpenWetWare

(Difference between revisions)
Jump to: navigation, search
m (Bibliography)
Line 37: Line 37:
# tha3 pmid=8298130  
# tha3 pmid=8298130  
# tha4 pmid=1741036
# tha4 pmid=1741036
# tha5 pmid=8475124

Revision as of 15:05, 7 July 2006


Project Overview

  • Our goal is to to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
  • The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
  • As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
  • We expect that molecular containers could have several interesting scientific and clinical applications, such as
    • Drug and gene delivery
    • Bio-marker scavenging (early detection of biomarkers)
    • Directed evolution (compartmentalized selections)
    • Using multiplexing for combinatorial chemical synthesis
    • Capture and stabilization of multiprotein complexes
    • Protein folding (chaperones)
    • Cell sorting

Container Specs


Container Designs

Latch Designs



Existing code

Thrombin-aptamer experiments


Error fetching PMID 8107090:
Error fetching PMID 15945116:
Error fetching PMID 8298130:
Error fetching PMID 1741036:
Error fetching PMID 8475124:
  1. Error fetching PMID 8107090: [tha1]
  2. Error fetching PMID 15945116: [tha2]
  3. Error fetching PMID 8298130: [tha3]
  4. Error fetching PMID 1741036: [tha4]
  5. Error fetching PMID 8475124: [tha5]
All Medline abstracts: PubMed HubMed


Most recent (Week 3)

Week 2: Original proposal

Working Team Members

Personal tools