IGEM:Harvard/2006/DNA nanostructures

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Revision as of 14:05, 7 July 2006

Contents

Project Overview

  • Our goal is to to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
  • The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
  • As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
  • We expect that molecular containers could have several interesting scientific and clinical applications, such as
    • Drug and gene delivery
    • Bio-marker scavenging (early detection of biomarkers)
    • Directed evolution (compartmentalized selections)
    • Using multiplexing for combinatorial chemical synthesis
    • Capture and stabilization of multiprotein complexes
    • Protein folding (chaperones)
    • Cell sorting

Container Specs

Image:iGEM_harv06_mattspecs.gif

Container Designs

Latch Designs

Image:iGEM_harv06_mattlatch.gif

Coding

Existing code

Thrombin-aptamer experiments

Bibliography

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Error fetching PMID 8475124:
  1. Error fetching PMID 8107090: [tha1]
  2. Error fetching PMID 15945116: [tha2]
  3. Error fetching PMID 8298130: [tha3]
  4. Error fetching PMID 1741036: [tha4]
  5. Error fetching PMID 8475124: [tha5]
All Medline abstracts: PubMed HubMed

Presentations

Most recent (Week 3)

Week 2: Original proposal

Working Team Members

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