IGEM:Harvard/2006/DNA nanostructures
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==Project Overview== | ==Project Overview== | ||
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**Cell sorting | **Cell sorting | ||
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==Working Team Members== | ==Working Team Members== | ||
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*[[User:Vlau|Valerie Lau]] ([[User_talk:Vlau|talk]]) | *[[User:Vlau|Valerie Lau]] ([[User_talk:Vlau|talk]]) | ||
*[[User:Matthewmeisel|Matthew Meisel]] ([[User_talk:Matthewmeisel|talk]]) | *[[User:Matthewmeisel|Matthew Meisel]] ([[User_talk:Matthewmeisel|talk]]) | ||
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| + | ==Primary Advisers== | ||
| + | *[[User:Wmshih|William Shih]] ([[User_talk:Wmshih|talk]]) | ||
| + | *[[User:ShawnDouglas|Shawn Douglas]] ([[User_talk:ShawnDouglas|talk]]) | ||
Revision as of 15:05, 11 July 2006
- Project Overview
- Designs
- Notebook
- Protocols
- Presentations
- Literature
Project Overview
- Our goal is to to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
- The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
- As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
- We expect that molecular containers could have several interesting scientific and clinical applications, such as
- Drug and gene delivery
- Bio-marker scavenging (early detection of biomarkers)
- Directed evolution (compartmentalized selections)
- Using multiplexing for combinatorial chemical synthesis
- Capture and stabilization of multiprotein complexes
- Protein folding (chaperones)
- Cell sorting
