IGEM:Harvard/2007/Brainstorming/
Brainstorming of Possible Adhesion Targets (feel free to add/reorganize/whatever--I just thought I'd get this started): ~~other mammalian~~
- Laminins
- fibronectin
~~Mammalian cell surface proteins~~
~~Protozoan membrane proteins~~
- By the way, I was thinking about expressing plasmodium falciparum proteins on the surface of E coli and maybe showing somehow that an immune rxn can be elicited in mice or sthing like that e.g. in humans, "High levels of plasma chitotriosidase are a marker of macrophage activation..."
- Speaking on targets, heregoes:
- EBA-175, a 175 kDa 'erythrocyte binding antigen' from P. falciparum
- DBP, Duffy-binding protein from P. vivax and P. knowlesi
- SSP2, Plasmodium sporozoite surface protein-2. Also known as TRAP (thrombospondin-related adhesive protein).
- Proteins with homology to SSP2/TRAP from Toxoplasma (MIC2), Eimeria (Etp100), and Cryptosporidium
- CTRP, circumsporozoite- and TRAP-related protein of Plasmodium found in the ookinete stage
- (see http://www.tulane.edu/~wiser/malaria/cmb.html#junction)
~Viral Membrane Proteins~
- Influenza A M2 Protein
- Neuraminidase
Hemaglutinin Semliki Forest membrane proteins Epstein Barr LMP1/LMP2 HIV gp120
~Cancer Membrane Proteins~ Eag1 potassium channels Muc1 NGEP-L
~~Assorted~~ Presenilin
Btw, can we reorganize the brainstorming page to put the older brainstorming into folders or something and only have the stuff relevant to our project still on the front page? I have no idea how to do this...thanks. -Shaunak
Hope you like the formatting.
--Stephanie (5/12)
Brainstorming, 4/23 to 5/9
Misc Brainstorming, pre-5/9
Brainstorming from Second Meeting, 4/05
Brainstorming from First Meeting, 3/19
