IGEM:Harvard/2010/Brainstorming - Revision history

PatrickBoyle: /* Meeting 2: April 24, 2010 */

PatrickBoyle — Fri, 07 May 2010 14:45:05 GMT

Meeting 2: April 24, 2010

←Older revision		Revision as of 14:45, 7 May 2010
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	=='''Meeting 2: April 24, 2010'''==		=='''Meeting 2: April 24, 2010'''==

-	'''Ideas''': Focus on food and ~~kill-switches~~	+	'''Ideas''': Focus on food and genetic fences

	''4 main components'': Educational;Control Device--> how to tightly control RNAi; kill switch; color/flavours/scents		''4 main components'': Educational;Control Device--> how to tightly control RNAi; kill switch; color/flavours/scents
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	''*(Minimum)Central Goal'': Showing inducible production of different products in agrobacteria		''*(Minimum)Central Goal'': Showing inducible production of different products in agrobacteria
-	*''Safety'': ~~Kill-switches~~, color indicator (different colors identify different genes that are expressed)	+	*''Safety'': Genetic fences, color indicator (different colors identify different genes that are expressed)
	*''Above and Beyond'': Fully-equipped tool-kit(educational component) to grow at home		*''Above and Beyond'': Fully-equipped tool-kit(educational component) to grow at home

	*[http://openwetware.org/wiki/IGEM:Harvard/2010/Brainstorming/food Next-Steps]: choose what allergy(ies) to target, find the genes involved		*[http://openwetware.org/wiki/IGEM:Harvard/2010/Brainstorming/food Next-Steps]: choose what allergy(ies) to target, find the genes involved

Mara C. Inniss at 21:05, 24 April 2010

Mara C. Inniss — Sat, 24 Apr 2010 21:05:37 GMT

←Older revision		Revision as of 21:05, 24 April 2010
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	Things biology is good at: parallel processing, self-regeneration & fast multiplication, communication		Things biology is good at: parallel processing, self-regeneration & fast multiplication, communication

-	=='''Meeting 1 April 10, 2010'''==	+	=='''Meeting 1: April 10, 2010'''==

-	== Food or Energy ==	+	=== Food or Energy ===

	*Allergen free foods - custom garden toolbox; bacteria to break down lactose; lettuce allergy; cilantro; eggplant enzyme; particular plants (plants are less cmoplex to figure out)		*Allergen free foods - custom garden toolbox; bacteria to break down lactose; lettuce allergy; cilantro; eggplant enzyme; particular plants (plants are less cmoplex to figure out)
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	*GE foods toolkit (grow your own healthy food--flavor, color, not too robust b/c it can't get out into the environment, propose that each gene is coexpressed with a different pigment so you know that it is safe).		*GE foods toolkit (grow your own healthy food--flavor, color, not too robust b/c it can't get out into the environment, propose that each gene is coexpressed with a different pigment so you know that it is safe).

-	==Environment==	+	===Environment===

	*[E. Chromi]		*[E. Chromi]
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	*Organism that breaks down [something] (for removal of unwanted waste).		*Organism that breaks down [something] (for removal of unwanted waste).

-	==Health or Medicine==	+	===Health or Medicine===

	*Invasin-based tumor-seeking bacteria. (what else could invasive bacteria do?) It would be cool just to do a proof of principle in designing bacteria that exclusively invade a certain tissue type (muscle, liver, etc), dying in the absense of some signal unique to that tissue. You can imagine the usefulness for medicine - it could be a vector for hyper-specific drug delivery, or could replace a lost function in the tissue (ie, producing insulin for diabetics, etc). Even just showing that we can target a bacterium to a specific tissue exclusively (Time permitting, two or three different tissues) would be a springboard for some pretty sweet grandiose claims about future applications, a la team Cambridge last year.		*Invasin-based tumor-seeking bacteria. (what else could invasive bacteria do?) It would be cool just to do a proof of principle in designing bacteria that exclusively invade a certain tissue type (muscle, liver, etc), dying in the absense of some signal unique to that tissue. You can imagine the usefulness for medicine - it could be a vector for hyper-specific drug delivery, or could replace a lost function in the tissue (ie, producing insulin for diabetics, etc). Even just showing that we can target a bacterium to a specific tissue exclusively (Time permitting, two or three different tissues) would be a springboard for some pretty sweet grandiose claims about future applications, a la team Cambridge last year.
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	*Bacteria for weight loss, blood diagnostics		*Bacteria for weight loss, blood diagnostics

-	==Manufacturing==	+	===Manufacturing===

	*Biofilms		*Biofilms
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	*DNA/nano assembly		*DNA/nano assembly

-	==New Application==	+	===New Application===

	*Robots that can smell, eat, give off signals in response to different environmenmtal stimuli		*Robots that can smell, eat, give off signals in response to different environmenmtal stimuli
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	**Cons of Biological systems:		**Cons of Biological systems:

-	==Foundation Advance==	+	===Foundation Advance===
	*Slime molds, or other types of multicellular fungi - not sure what we'd do with them, but they've got some very cool properties (reproduction, communication, algorithms). I remember reading something about algorithms governing where hyphae grow, and how that has been linked to traffic design...I'll see if I can find it again...		*Slime molds, or other types of multicellular fungi - not sure what we'd do with them, but they've got some very cool properties (reproduction, communication, algorithms). I remember reading something about algorithms governing where hyphae grow, and how that has been linked to traffic design...I'll see if I can find it again...

	*Sound responsive/mechano-responsive organisms - bacteria that react in different ways in response to loud noises, or high frequencies (screaming yeast?)		*Sound responsive/mechano-responsive organisms - bacteria that react in different ways in response to loud noises, or high frequencies (screaming yeast?)

-	==Information Processing==	+	===Information Processing===
	*Parallel computing/bacterial computation		*Parallel computing/bacterial computation
	*electronic biosensors /smelling robots		*electronic biosensors /smelling robots
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	*yeast memory		*yeast memory

-	==Software Tool==	+	===Software Tool===
	*computer aided design		*computer aided design
	*games		*games

Anugraha Raman: /* Meeting 2: April 24, 2010 */

Anugraha Raman — Sat, 24 Apr 2010 18:00:25 GMT

Meeting 2: April 24, 2010

←Older revision		Revision as of 18:00, 24 April 2010
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	*''Above and Beyond'': Fully-equipped tool-kit(educational component) to grow at home		*''Above and Beyond'': Fully-equipped tool-kit(educational component) to grow at home

-	*[http://openwetware.org/wiki/IGEM:Harvard/2010/Brainstorming/food\|Next-Steps]: choose what allergy(ies) to target, find the genes involved	+	*[http://openwetware.org/wiki/IGEM:Harvard/2010/Brainstorming/food Next-Steps]: choose what allergy(ies) to target, find the genes involved

Anugraha Raman: /* Meeting 2: April 24, 2010 */

Anugraha Raman — Sat, 24 Apr 2010 17:59:38 GMT

Meeting 2: April 24, 2010

←Older revision		Revision as of 17:59, 24 April 2010
Line 90:		Line 90:
	*''Above and Beyond'': Fully-equipped tool-kit(educational component) to grow at home		*''Above and Beyond'': Fully-equipped tool-kit(educational component) to grow at home

-	*[~~Next Steps \|~~http://openwetware.org/wiki/IGEM:Harvard/2010/Brainstorming]: choose what allergy(ies) to target, find the genes involved	+	*[http://openwetware.org/wiki/IGEM:Harvard/2010/Brainstorming/food\|Next-Steps]: choose what allergy(ies) to target, find the genes involved

Anugraha Raman at 17:58, 24 April 2010

Anugraha Raman — Sat, 24 Apr 2010 17:58:32 GMT

←Older revision		Revision as of 17:58, 24 April 2010
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	*''Above and Beyond'': Fully-equipped tool-kit(educational component) to grow at home		*''Above and Beyond'': Fully-equipped tool-kit(educational component) to grow at home

-	*[Next Steps]: choose what allergy(ies) to target, find the genes involved	+	*[Next Steps \|http://openwetware.org/wiki/IGEM:Harvard/2010/Brainstorming]: choose what allergy(ies) to target, find the genes involved

Anugraha Raman at 17:50, 24 April 2010

Anugraha Raman — Sat, 24 Apr 2010 17:50:14 GMT

←Older revision		Revision as of 17:50, 24 April 2010
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	=='''Meeting 1 April 10, 2010'''==		=='''Meeting 1 April 10, 2010'''==
-	==Food or Energy==	+
		+	== Food or Energy ==
		+
	*Allergen free foods - custom garden toolbox; bacteria to break down lactose; lettuce allergy; cilantro; eggplant enzyme; particular plants (plants are less cmoplex to figure out)		*Allergen free foods - custom garden toolbox; bacteria to break down lactose; lettuce allergy; cilantro; eggplant enzyme; particular plants (plants are less cmoplex to figure out)

Anugraha Raman: /* Meeting 2: April 24, 2010 */

Anugraha Raman — Sat, 24 Apr 2010 17:43:59 GMT

Meeting 2: April 24, 2010

←Older revision		Revision as of 17:43, 24 April 2010
Line 78:		Line 78:
	=='''Meeting 2: April 24, 2010'''==		=='''Meeting 2: April 24, 2010'''==

-	Ideas: Focus on food and kill-switches	+	'''Ideas''': Focus on food and kill-switches
-	~~4 main components: Educational;Control Device--> how to tightly control RNAi; kill switch; color/flavours/scents~~	+

-	~~Allergy Foods: peanut allergies, vegetable allergies, choclate (actually that many people aren~~'~~t that allergic to the actual coco plant, but~~ to ~~other things present in the chocolate), nut allergies~~	+	''4 main components'': Educational;Control Device--> how to tightly control RNAi; kill switch; color/flavours/scents

-	*(Minimum)Central Goal: Showing inducible production of different products in agrobacteria	+	''Allergy Foods'': peanut allergies, vegetable allergies, choclate (actually that many people aren't that allergic to the actual coco plant, but to other things present in the chocolate), nut allergies
-	*Safety: Kill-switches, color indicator (different colors identify different genes that are expressed)	+
-	*Above and Beyond: Fully-equipped tool-kit(educational component) to grow at home	+	''*(Minimum)Central Goal'': Showing inducible production of different products in agrobacteria
		+	*''Safety'': Kill-switches, color indicator (different colors identify different genes that are expressed)
		+	*''Above and Beyond'': Fully-equipped tool-kit(educational component) to grow at home

	*[Next Steps]: choose what allergy(ies) to target, find the genes involved		*[Next Steps]: choose what allergy(ies) to target, find the genes involved

Anugraha Raman: /* Meeting 2: April 24, 2010 */

Anugraha Raman — Sat, 24 Apr 2010 17:42:20 GMT

Meeting 2: April 24, 2010

←Older revision		Revision as of 17:42, 24 April 2010
Line 79:		Line 79:

	Ideas: Focus on food and kill-switches		Ideas: Focus on food and kill-switches
		+	4 main components: Educational;Control Device--> how to tightly control RNAi; kill switch; color/flavours/scents

	Allergy Foods: peanut allergies, vegetable allergies, choclate (actually that many people aren't that allergic to the actual coco plant, but to other things present in the chocolate), nut allergies		Allergy Foods: peanut allergies, vegetable allergies, choclate (actually that many people aren't that allergic to the actual coco plant, but to other things present in the chocolate), nut allergies
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	*(Minimum)Central Goal: Showing inducible production of different products in agrobacteria		*(Minimum)Central Goal: Showing inducible production of different products in agrobacteria
	*Safety: Kill-switches, color indicator (different colors identify different genes that are expressed)		*Safety: Kill-switches, color indicator (different colors identify different genes that are expressed)
-	*Above and Beyond: Fully-equipped tool-kit (grow at home~~, rnai into the seedling)~~	+	*Above and Beyond: Fully-equipped tool-kit(educational component) to grow at home

	*[Next Steps]: choose what allergy(ies) to target, find the genes involved		*[Next Steps]: choose what allergy(ies) to target, find the genes involved

Anugraha Raman: /* Meeting 2: April 24, 2010 */

Anugraha Raman — Sat, 24 Apr 2010 17:39:23 GMT

Meeting 2: April 24, 2010

←Older revision		Revision as of 17:39, 24 April 2010
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	Ideas: Focus on food and kill-switches		Ideas: Focus on food and kill-switches

-	Allergy ~~Foosds~~: peanut allergies, vegetable allergies, choclate (actually that many people aren't that allergic to the actual coco plant, but to other things present in the chocolate), nut allergies	+	Allergy Foods: peanut allergies, vegetable allergies, choclate (actually that many people aren't that allergic to the actual coco plant, but to other things present in the chocolate), nut allergies
-		+

	*(Minimum)Central Goal: Showing inducible production of different products in agrobacteria		*(Minimum)Central Goal: Showing inducible production of different products in agrobacteria
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	*Above and Beyond: Fully-equipped tool-kit (grow at home, rnai into the seedling)		*Above and Beyond: Fully-equipped tool-kit (grow at home, rnai into the seedling)

-	*Next Steps: choose what allergy(ies) to target, find the genes involved	+	*[Next Steps]: choose what allergy(ies) to target, find the genes involved

Anugraha Raman: /* Meeting 2: April 24, 2010 */

Anugraha Raman — Sat, 24 Apr 2010 17:37:21 GMT

Meeting 2: April 24, 2010

←Older revision		Revision as of 17:37, 24 April 2010
Line 77:		Line 77:

	=='''Meeting 2: April 24, 2010'''==		=='''Meeting 2: April 24, 2010'''==
		+
		+	Ideas: Focus on food and kill-switches
		+
		+	Allergy Foosds: peanut allergies, vegetable allergies, choclate (actually that many people aren't that allergic to the actual coco plant, but to other things present in the chocolate), nut allergies
		+
		+
		+	*(Minimum)Central Goal: Showing inducible production of different products in agrobacteria
		+	*Safety: Kill-switches, color indicator (different colors identify different genes that are expressed)
		+	*Above and Beyond: Fully-equipped tool-kit (grow at home, rnai into the seedling)
		+
		+	*Next Steps: choose what allergy(ies) to target, find the genes involved