IGEM:IMPERIAL/2008/New/Home

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This year the Imperial College iGEM Team aims to develop a genetically-engineered Biofabricator, using the Gram-positive bacterium Bacillus subtilis. Our Biofabricator aims to produce self-assembling biomaterials in specified 3D shapes, using light as the trigger. This is achieved in three stages. First using 3D holography and by utilising an endogenous light-sensing mechanism, the bacteria is captured in the desired location.  
This year the Imperial College iGEM Team aims to develop a genetically-engineered Biofabricator, using the Gram-positive bacterium Bacillus subtilis. Our Biofabricator aims to produce self-assembling biomaterials in specified 3D shapes, using light as the trigger. This is achieved in three stages. First using 3D holography and by utilising an endogenous light-sensing mechanism, the bacteria is captured in the desired location.  
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[[Image:Imperial_2008_Bioprinter_Cartoon.png |center|500px| Overview of our planned system]]  
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[[Image:Imperial_2008_Bioprinter_Cartoon.png |center|600px| Overview of our planned system]]  
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Next bacterial locomotion is suspended in the region of interest using a recently-discovered clutch mechanism. This involves disengaging the flagellum from the motor protein. Finally, when our bacteria are stationary in the correct location, the biomaterial production is triggered. These biomaterials can self-assemble to form a 3D bio-scaffold.  
Next bacterial locomotion is suspended in the region of interest using a recently-discovered clutch mechanism. This involves disengaging the flagellum from the motor protein. Finally, when our bacteria are stationary in the correct location, the biomaterial production is triggered. These biomaterials can self-assemble to form a 3D bio-scaffold.  
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[[Image:Imperial_2008_Basic_Circuit.jpg |center|400px |Basic Circuit Diagram]]
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[[Image:Imperial_2008_Basic_Circuit.jpg |center|450px |Basic Circuit Diagram]]
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Applications of our Biofabricator range from regenerative tissue engineering to Bio-Couture.
Applications of our Biofabricator range from regenerative tissue engineering to Bio-Couture.

Revision as of 13:01, 27 September 2008






Welcome to the Imperial 2008 iGEM project page. It's Friday, September 19 and a great day to read about an awesome iGEM project!



This year the Imperial College iGEM Team aims to develop a genetically-engineered Biofabricator, using the Gram-positive bacterium Bacillus subtilis. Our Biofabricator aims to produce self-assembling biomaterials in specified 3D shapes, using light as the trigger. This is achieved in three stages. First using 3D holography and by utilising an endogenous light-sensing mechanism, the bacteria is captured in the desired location.

Overview of our planned system



Next bacterial locomotion is suspended in the region of interest using a recently-discovered clutch mechanism. This involves disengaging the flagellum from the motor protein. Finally, when our bacteria are stationary in the correct location, the biomaterial production is triggered. These biomaterials can self-assemble to form a 3D bio-scaffold.

Basic Circuit Diagram



Applications of our Biofabricator range from regenerative tissue engineering to Bio-Couture.

Please continue on to our project pages - you may want to start with our >>> Project Specifications >>>



Imperial's 2008 iGEM team has received sponsorship from a number of generous companies:



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