IGEM:IMPERIAL/2009/Anti cancer

Principles

Major considerations:
MYROSINASE
1.Production of isothiocyanites inhibits thioredoxin reductases, which kills cancer cells:

• Add vegetable soup
  
• Concentrate in cell and extract/purify
  

KEY QUESTIONS

• Do all cells contain thioredoxin reductase?
  
• Would isothiocyanites work on all cells?
  
• How does thioredoxin reductase inhibition lead to cancer cell death?
  
• What is the missing link between vegetables and perturbation into cells?
  

FURTHER APPLICATIONS

• Delivery of enzymes;KO proteosome
  
• Aggregate encapsulated cells into structure: wire, colum?
  
• Avoid medical track! Look at manufacturing, biofabrication... etc (See James Chappel's email)
  
• Concentrating ions
  
• Charge storing
  
• Purification
  
• Metal detoxification
  

APPLICATION WILL DETERMINE

• Chassis
  
• Mechanism of encapsulation