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{{Imperial2010/Header}}
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“More than two billion people around the world live with unrelenting
{| cellspacing="5"
illness due to parasites” - WHO Director General Lee Jong-wook.
|width="180px" class="blue" |
Synthetic biology offers great opportunity for biosensors, however
<!-- RESOURCES HEADER with edit link-->
current designs require hours before useful output. To tackle this
<h3>Project</h3>
issue in the field, it's crucial that our project can respond in
<hr/>
minutes, hence we have engineered a fast, modular sensor framework.
<!-- END RESOURCES HEADER-->
This allows detection of a range of different parasites, and may also
be used as an environmental tool for mapping their spread. We have
developed two new technologies that enable our modular input/output -
a novel cell surface biosensor, customisable for specific parasitic
proteases, linked through quorum-sensing to a new 'fast-response'
module capable of producing a detectable output in minutes. To
demonstrate the concept, we've designed and fabricated B. subtilis to
give a striking colour readout upon detecting the waterborne
Schistosoma parasite which affects 200 million people worldwide.


===Modules===
* [[IGEM:Imperial/2010/Detection_module | Detection module]]
* [[IGEM:Imperial/2010/Fast_Response_module | Fast Response module]]
* [[IGEM:Imperial/2010/Output_module | Output module]]
* [[IGEM:Imperial/2010/Ethics | Ethical issues]]
* [[IGEM:Imperial/2010/Parts | Parts]]
* [[IGEM:Imperial/2010/Papers | Papers]]


===Drylab===
<span style="font-size:2em;color:#555555;">This website is not our main website! Please head to
* [[IGEM:Imperial/2010/Modelling | Modelling]]
[http://2010.igem.org/Team:Imperial_College_London http://2010.igem.org/Team:Imperial_College_London] for the full details.</span>


===Temp===
* [[IGEM:Imperial/2010/Parts/Synthesis | Synthesis]]
* [[IGEM:Imperial/2010/Strategy | Strategy]]
===Wetlab===
* [[IGEM:Imperial/2010/Lab_Work | Lab Work]]
* [[IGEM:Imperial/2010/Protocol | Protocol]]
===Extras===
* [[IGEM:Imperial/2010/Projects | Initial Brainstorming]]
* [[IGEM:Imperial/2010/Journal_Club | Journal Club]]
* [[IGEM:Imperial/2010/Movie_Night | Movie Night]]
* [[IGEM:Imperial/2010/Judging_Criteria | Judging Criteria]]
===Links===
* [http://www.subtiwiki.uni-goettingen.de/wiki/index.php/Main_Page SubtiWiki]
* [http://www.nmr2.buffalo.edu/nesg.wiki/Main_Page Structural Bio Wiki]
* [http://www.rcsb.org/pdb/home/home.do Protein Data Bank w/ reference papers]
<!-- PEOPLE HEADER with edit link-->
<h3><html>
<img src="http://openwetware.org/images/3/39/Icon_groups.png" alt="People">
</html>People</h3>
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<p id="popshow">Students (Click me)</p>
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  <li><a href="http://openwetware.org/wiki/User:Piotr_D._Faba" class="popt">Piotr D Faba</a></li>
  <li><a href="http://openwetware.org/wiki/User:Harriet_D._Gliddon" class="popt">Harriet D Gliddon</a></li>
  <li><a href="http://openwetware.org/wiki/User:Nicolas_Kylilis" class="popt">Nicolas Kylilis</a></li>
  <li><a href="http://openwetware.org/wiki/User:Benjamin_Miller" class="popt">Benjamin Miller</a></li>
  <li><a href="http://openwetware.org/wiki/User:Anita_Nguyen" class="popt">Anita Nguyen</a></li>
  <li><a href="http://openwetware.org/wiki/User:Wolfgang_Pernice" class="popt">Wolfgang Pernice</a></li>
  <li><a href="http://openwetware.org/wiki/User:Kyasha_Sri_Ranjan" class="popt">Kyasha Sri Ranjan</a></li>
  <li><a href="http://openwetware.org/wiki/User:Madeline_Rounds" class="popt">Madeline Rounds</a></li>
  <li><a href="http://openwetware.org/wiki/User:A._Florian_Sessler" class="popt">A Florian Sessler</a></li>
  <li><a href="http://openwetware.org/wiki/User:Kirill_Shkura" class="popt">Kirill Shkura</a></li>
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'''Advisors'''
* [[User:Chris_D_Hirst | Chris D Hirst]]
* Kirsten Jensen
* [[Tom_Ellis | Tom Ellis]]
* [http://www.bg.ic.ac.uk/research/g.stan Guy-Bart Stan]
|width="600px" class="white" |
<!-- INFORMATION HEADER with edit link-->
<h3>Project description</h3>
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----
Many biological systems are generally very slow. Most rely on transcription-based platforms which can take from several hours to a week to produce a detectable response. Our concept is an adaptable, modular and robust fast response system, which is fundamental for modern applications in synthetic biology.
{| class="wikitable" style="text-align: center; width: 20%; height: 170px;"
  | [[Image:Detection module.JPG|thumb|center|200px]]
  | [[Image:Fast response module.JPG|thumb|center|200px]]
  | [[Image:Output module.JPG|thumb|center|200px]]
|}
<h3>Recent Updates</h3>
----
{{Special:RecentChanges/IGEM:Imperial&limit=15}}
<LNCalendar></LNCalendar>
|}
</div>


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Latest revision as of 13:26, 24 October 2010

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</html> “More than two billion people around the world live with unrelenting illness due to parasites” - WHO Director General Lee Jong-wook. Synthetic biology offers great opportunity for biosensors, however current designs require hours before useful output. To tackle this issue in the field, it's crucial that our project can respond in minutes, hence we have engineered a fast, modular sensor framework. This allows detection of a range of different parasites, and may also be used as an environmental tool for mapping their spread. We have developed two new technologies that enable our modular input/output - a novel cell surface biosensor, customisable for specific parasitic proteases, linked through quorum-sensing to a new 'fast-response' module capable of producing a detectable output in minutes. To demonstrate the concept, we've designed and fabricated B. subtilis to give a striking colour readout upon detecting the waterborne Schistosoma parasite which affects 200 million people worldwide.


This website is not our main website! Please head to http://2010.igem.org/Team:Imperial_College_London for the full details.




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