IGEM:Imperial/2010

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<h3>Project</h3>
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===Modules===
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* [[IGEM:Imperial/2010/Detection_module | Detection module]]
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* [[IGEM:Imperial/2010/Fast_Response_module | Fast Response module]]
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* [[IGEM:Imperial/2010/Output_module | Output module]]
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* [[IGEM:Imperial/2010/Ethics | Ethical issues]]
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* [[IGEM:Imperial/2010/Parts | Parts]]
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* [[IGEM:Imperial/2010/Papers | Papers]]
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===Drylab===
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* [[IGEM:Imperial/2010/Modelling | Modelling]]
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===Temp===
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* [[IGEM:Imperial/2010/Parts/Synthesis | Synthesis]]
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* [[IGEM:Imperial/2010/Strategy | Strategy]]
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===Wetlab===
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* [[IGEM:Imperial/2010/Lab_Work | Lab Work]]
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* [[IGEM:Imperial/2010/Protocol | Protocol]]
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===Extras===
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* [[IGEM:Imperial/2010/Projects | Initial Brainstorming]]
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* [[IGEM:Imperial/2010/Journal_Club | Journal Club]]
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* [[IGEM:Imperial/2010/Movie_Night | Movie Night]]
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* [[IGEM:Imperial/2010/Judging_Criteria | Judging Criteria]]
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===Links===
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* [http://www.subtiwiki.uni-goettingen.de/wiki/index.php/Main_Page SubtiWiki]
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* [http://www.nmr2.buffalo.edu/nesg.wiki/Main_Page Structural Bio Wiki]
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* [http://www.rcsb.org/pdb/home/home.do Protein Data Bank w/ reference papers]
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<title>Imperial iGEM 2010</title>
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<p id="popshow">Students (Click me)</p>
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  <li><a href="http://openwetware.org/wiki/User:Piotr_D._Faba" class="popt">Piotr D Faba</a></li>
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  <li><a href="http://openwetware.org/wiki/User:Harriet_D._Gliddon" class="popt">Harriet D Gliddon</a></li>
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  <li><a href="http://openwetware.org/wiki/User:Nicolas_Kylilis" class="popt">Nicolas Kylilis</a></li>
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  <li><a href="http://openwetware.org/wiki/User:Benjamin_Miller" class="popt">Benjamin Miller</a></li>
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  <li><a href="http://openwetware.org/wiki/User:Anita_Nguyen" class="popt">Anita Nguyen</a></li>
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  <li><a href="http://openwetware.org/wiki/User:Wolfgang_Pernice" class="popt">Wolfgang Pernice</a></li>
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  <li><a href="http://openwetware.org/wiki/User:Kyasha_Sri_Ranjan" class="popt">Kyasha Sri Ranjan</a></li>
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  <li><a href="http://openwetware.org/wiki/User:Madeline_Rounds" class="popt">Madeline Rounds</a></li>
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  <li><a href="http://openwetware.org/wiki/User:A._Florian_Sessler" class="popt">A Florian Sessler</a></li>
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  <li><a href="http://openwetware.org/wiki/User:Kirill_Shkura" class="popt">Kirill Shkura</a></li>
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<li><a href="http://openwetware.org/wiki/User:Team_Gallery" class="popt">Team Gallery</a></li>
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'''Advisors'''
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* [[User:Chris_D_Hirst | Chris D Hirst]]
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* Kirsten Jensen
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* [[Tom_Ellis | Tom Ellis]]
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* [http://www.bg.ic.ac.uk/research/g.stan Guy-Bart Stan]
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“More than two billion people around the world live with unrelenting
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<h3>Project description</h3>
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illness due to parasites” - WHO Director General Lee Jong-wook.
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Synthetic biology offers great opportunity for biosensors, however
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current designs require hours before useful output. To tackle this
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issue in the field, it's crucial that our project can respond in
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Many biological systems are generally very slow. Most rely on transcription-based platforms which can take from several hours to a week to produce a detectable response. Our concept is an adaptable, modular and robust fast response system, which is fundamental for modern applications in synthetic biology.  
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minutes, hence we have engineered a fast, modular sensor framework.
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This allows detection of a range of different parasites, and may also
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  | [[Image:Detection module.JPG|thumb|center|200px]]
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be used as an environmental tool for mapping their spread. We have
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  | [[Image:Fast response module.JPG|thumb|center|200px]]
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developed two new technologies that enable our modular input/output -
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  | [[Image:Output module.JPG|thumb|center|200px]]
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a novel cell surface biosensor, customisable for specific parasitic
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proteases, linked through quorum-sensing to a new 'fast-response'
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module capable of producing a detectable output in minutes. To
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demonstrate the concept, we've designed and fabricated B. subtilis to
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give a striking colour readout upon detecting the waterborne
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Schistosoma parasite which affects 200 million people worldwide.
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<h3>Recent Updates</h3>
 
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Revision as of 12:09, 23 September 2010

“More than two billion people around the world live with unrelenting illness due to parasites” - WHO Director General Lee Jong-wook. Synthetic biology offers great opportunity for biosensors, however current designs require hours before useful output. To tackle this issue in the field, it's crucial that our project can respond in minutes, hence we have engineered a fast, modular sensor framework. This allows detection of a range of different parasites, and may also be used as an environmental tool for mapping their spread. We have developed two new technologies that enable our modular input/output - a novel cell surface biosensor, customisable for specific parasitic proteases, linked through quorum-sensing to a new 'fast-response' module capable of producing a detectable output in minutes. To demonstrate the concept, we've designed and fabricated B. subtilis to give a striking colour readout upon detecting the waterborne Schistosoma parasite which affects 200 million people worldwide.



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