IGEM:MIT/2005/Nitrocefin

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Nitrocefin is normally excluded by the outer cell membrane, but if able to pass this barrier it can be cleaved by beta-lactabase localized within the periplasmic space. Cleavage results in a color change from yellow to red, and this can be used to monitor outer membrane permeabilization.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=89666

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