IGEM:MIT/2005/PATHWAYS!!: Difference between revisions
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==<font color=red>Pathways We'll Try== | ==<font color=red>Pathways We'll Try== | ||
*Put pathways you think is worth a try on here. | *Put pathways you think is worth a try on here. Eventually, try to make a list of 5 or less. | ||
*Criteria: | *Criteria: | ||
:best is dimerization system, conformational change is considerable | :best is dimerization system, conformational change is considerable |
Revision as of 08:08, 28 June 2005
Pathways We'll Try
- Put pathways you think is worth a try on here. Eventually, try to make a list of 5 or less.
- Criteria:
- best is dimerization system, conformational change is considerable
- has characterized signal path
- not essential to the cells
Pathway Websites
- Cell Membrane Pathways
- [1]
- Links to Collections of Pathways
- Different Types of Cytokine Receptor
- BioCarta
ToxR
- [[../ *ToxR* info, etc./]]
Chemotaxis
http://www.rowland.harvard.edu/labs/bacteria/images/fret1.jpg
Papers on Chemotaxis/Dimerization:
MAKING SENSE OF IT ALL: BACTERIAL CHEMOTAXIS
Integrin Signalling
Picture Integrin signalling controls growth.
In Homo sapiens and mouse
TGF-Beta
Picture This pathway is in H. Sapiens.
Omp
e. coli
OmpR picture from 2004 UT project
Cytokine
Mammalian, S. Cerevisiae
Cytokines are small protein molecules that are the core of communication between immune system cells, and even between these cells and cells belonging to other tissue types. Cytokines act by binding to their cell-specific receptors. These receptors are located in the CELL MEMBRANE and each allows a distinct signal transduction cascade to start in the cell, that eventually will lead to biochemical and phenotypical changes in the target cell.
Most cytokine receptors lack intrinsic kinase activity. They are thought to transmit their regulatory signals primarily by the receptor-associated JAK (Janus kinase) family of tyrosine kinases. Ligand-binding to the receptor leads to JAK activation that phosphorylates cytoplasmic STAT (signal transducer and activator of transcription) proteins. Following phosphorylation on tyrosine residues, STATs are dimerized (resulting from phosphotyrosine - SH2 domain association). This dimerization is accompanied by translocation of STAT to the nucleus that results in DNA binding to specific response elements, and stimulation of gene transcription.
http://bbid.grc.nia.nih.gov/geneimages/2.Cytokine_Receptors.jpeg |
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anyone into flies?
- bunch of Drosophilia pathways ~25 tyrosine kinase pathways, some are rather obscure (i.e. the pathways are not super-crucial to regular life).
no, noone is into flys