IGEM:NYMU/2011

From OpenWetWare

< IGEM:NYMU(Difference between revisions)
Jump to: navigation, search
Current revision (05:02, 17 December 2012) (view source)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
 +
<font size="5">Tailoring Your Avator</font>
 +
 +
[[Image:2011_ok.png]]
== Goal ==  
== Goal ==  
Create <b>wireless neuro-stimulator</b>, focusing on achieving remote neuro-stimulation to minimize invasion and damage to the neuron.
Create <b>wireless neuro-stimulator</b>, focusing on achieving remote neuro-stimulation to minimize invasion and damage to the neuron.
Line 5: Line 8:
== Specific Aims ==
== Specific Aims ==
<b><font color="blue">(1) Wireless stimulation for neurons</font></b>
<b><font color="blue">(1) Wireless stimulation for neurons</font></b>
-
<b>(2) Minimization of neuro-immuno response</b>
+
 
 +
<b><font color="blue">(2) Minimization of neuro-immuno response</font></b>
== Our Design ==
== Our Design ==
-
To achieve this goal, we use a species of magnetic bacterium, Magnetospirillum magneticum AMB-1. We have chosen mms13, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we have utilized three genes to achieveneurosymbiosis within glial cells: MinC, a division inhibitor, INV, a gene for invasion and LLO, a gene for facilitating escapes from phagosomes.
+
To achieve this goal, we use a species of magnetic bacterium, Magnetospirillum magneticum AMB-1. We have chosen <b>mms13</b>, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we have utilized three genes to achieve<b>neurosymbiosis</b> within glial cells: <b><i>MinC</b></i>, a division inhibitor,<b><i>INV</b></i>, a gene for invasion and <b><i>LLO</b></i>, a gene for facilitating escapes from phagosomes.
   
   
-
<b>Our design is made up of the following two devices:</b>
+
Our design is made up of the following two devices:
-
(1) Optomagnetic Design
+
-
Bridging magnetics and optogenetics.
+
<font color="blue">(1)[http://2011.igem.org/Team:NYMU-Taipei/optomagnetic-design Optomagnetic Design]</font>
-
(2) NeuroSymbiosis
+
Bridging magnetics and optogenetics.
 +
 
 +
<font color="blue">(2)[http://2011.igem.org/Team:NYMU-Taipei/immunological-solution NeuroSymbiosis]</font>
   
   
Enabling magnetotactic bacteria to be neurosymbiosis with glia cells.
Enabling magnetotactic bacteria to be neurosymbiosis with glia cells.
 +
 +
[[Image:2011slogan ok.png]]

Current revision

Tailoring Your Avator

Image:2011_ok.png

Contents

Goal

Create wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize invasion and damage to the neuron.

Why Do We Want to Do That?

Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved.

Specific Aims

(1) Wireless stimulation for neurons

(2) Minimization of neuro-immuno response

Our Design

To achieve this goal, we use a species of magnetic bacterium, Magnetospirillum magneticum AMB-1. We have chosen mms13, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we have utilized three genes to achieveneurosymbiosis within glial cells: MinC</b>, a division inhibitor,<b>INV</b>, a gene for invasion and <b>LLO</b>, a gene for facilitating escapes from phagosomes.


Our design is made up of the following two devices:

(1)Optomagnetic Design

Bridging magnetics and optogenetics.

(2)NeuroSymbiosis


Enabling magnetotactic bacteria to be neurosymbiosis with glia cells.

Image:2011slogan ok.png

Personal tools