IGEM:Paris Bettencourt 2012/Notebooks/Delay group
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The aim of that subproject is to find a way to launch the destruction of either the construction or the organism after a certain laps of time.
Here we report the idea we have, and how we could make them real.
Here, we would place alginate beads, with controlled alginate matrix size into the capsule. The alginate beads contains theophylline, that would act as an activator of a riboswitch that would repress gene expression <ref>Topp et. al, 2008</ref>.
1. Topp, S. & Gallivan, J.P. Riboswitches in unexpected places - A synthetic riboswitch in a protein coding region. RNA journal 2498-2503 (2008) Paper