IGEM:Paris Bettencourt 2012/Previous Biosafety iGEM Projects: Difference between revisions
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They get rid of the exonucelase problem by inserting multiple protein binding site that will be degraded when division occurs, but not with exonucleases. The repressor gene is degraded after a certain time." | They get rid of the exonucelase problem by inserting multiple protein binding site that will be degraded when division occurs, but not with exonucleases. The repressor gene is degraded after a certain time." | ||
<p style="text-align:right;"> [http://2009.igem.org/wiki/images/5/5f/Kyoto_GEDD_2_kai.png Read More] </p> | <p style="text-align:right;"> [http://2009.igem.org/wiki/images/5/5f/Kyoto_GEDD_2_kai.png Read More] </p> | ||
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| <center> UNICAMP-EMSE_Brazil </center> | |||
| <center> 2011 </center> | |||
| <center> [http://2011.igem.org/Team:UNICAMP-EMSE_Brazil stress wars] </center> | |||
| Coli based production of anti-stress compounds in the organism to improve the quality of life | |||
| "no design but two suggestions : | |||
One suggestion in the biosafety of the researcher is to include in the iGEM parts kit the bacterial less endotoxicchassi (developed by Berkeley UC 2007), to avoid serious septic problems in the case of an accident that leads to an intense contact with the bacteria (eye or bloodstream contact, inhalation or ingestion). | |||
Another suggestion for population and environment safety is to (somehow) include in all biobricks an operating unit that detects if the bacteria is not in a culture media (detects some molecule produced through the metabolism of a specific media constituent) and express lysozyme to kill it if it's released in the environment (idea inspired by Team UNICAMP-Brazil 2009)." | |||
<p style="text-align:right;"> [http://2011.igem.org/Team:UNICAMP-EMSE_Brazil/Safety Read More] </p> | |||
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Revision as of 08:49, 12 June 2012
Team | Year | Project Name | Project Summary | Biosafety Idea |
---|---|---|---|---|
Kill switch | Kill switch. Our kill switch is designed by inserting an antimicrobial peptide (AMP) gene into E.Coli | |||
Engineer bacteria to accelerate plant root development | Toxin/antitoxin. Consits of the insertion of the Holin + Endolysine and Anti Holin genes. | |||
Bacteria that detects and signals the presence of nitrates | Encapsulation in a gel. We encapsulated our bacteria in beeds made out of a non toxic gel. | |||
Detect chitin,and alert the plant by stimulating an early hypersensitive response against infection. | A few ideas but no design:
| |||
Optimize production of terpenes in Saccharomyces cerevisiae yeast (to help trees fight invading beetles and fungi) | A few ideas (no design):
| |||
Heavy metal bioreporter and bioabsorbent engineering | A few superficial ideas:
| |||
Projects which could be useful for a space travelling:
|
Not about biosafety, but:
They do not believe that their BioBrick parts will have any negative effect on the environment. But they could be interested by our project! | |||
CONTROLLING ICE FORMATION.
|
Suicide mechanism: DNA nuclease.
| |||
Biosensor to detect metals in waste water | One idea (no design):
| |||
Decontamination of radioactive cobalt in water by a biofilm | Biofilm & Adherence =
| |||
Sensing methane gas and converting it into methanol | Kill switch = Toxin temperature induced
| |||
Endocrine-disrupting chemicals (EDCs) are chemicals that interact with the endocrine system by binding to hormone receptors, causing problems in sexual development and reproduction of organisms | Biosafety ideas:
| |||
Choa Choa's Delivery Service | Clotho Framework:
Clotho implements the current biosafety standards as outlined by the NIH and the CDC. Whenever a new part is instantiated, Clotho BLAST's its sequence against a databank of known virulence factors and pathogens and returns the RG number of the highest match. This framework ensures that every part in Clotho has a RG value associated with it. In addition, when composite parts are made by joining basic parts, the composite part is also assigned a BSL number. Finally, all strains in Clotho have a risk group. | |||
Engineer bacteria to allow them to transport packets of chemicals, and then form a network. | Promoter responsive to synthetic chemicals not present in nature. | |||
An easy way to allowing the insertion and/or deletion of genes in the E. coli chromosome in a minimal number of steps | FLP recombination to remove resistance gene, eg. FRT - Cm - FRT will remove the Cm resistance gene | |||
They want to make bread with yeast producing Vitamin | their yeast strain lacks functional pathways for seven essential aa. | |||
How to express a gene after a certain lifespan. The use Linear DNA, in which a repressor will be degraded after few cell division. | "they want to control exact cell’s life time (or death time) depending on the number of cell division times.
They get rid of the exonucelase problem by inserting multiple protein binding site that will be degraded when division occurs, but not with exonucleases. The repressor gene is degraded after a certain time." | |||
Coli based production of anti-stress compounds in the organism to improve the quality of life | "no design but two suggestions :
One suggestion in the biosafety of the researcher is to include in the iGEM parts kit the bacterial less endotoxicchassi (developed by Berkeley UC 2007), to avoid serious septic problems in the case of an accident that leads to an intense contact with the bacteria (eye or bloodstream contact, inhalation or ingestion). Another suggestion for population and environment safety is to (somehow) include in all biobricks an operating unit that detects if the bacteria is not in a culture media (detects some molecule produced through the metabolism of a specific media constituent) and express lysozyme to kill it if it's released in the environment (idea inspired by Team UNICAMP-Brazil 2009)." | |||