IGEM:Stanford/2009/GCPR: Difference between revisions
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*Engineering G protein-coupled receptor expression in bacteria, article from PNAS, Sept. 2008: http://www.pnas.org/content/105/39/14747.full | *Engineering G protein-coupled receptor expression in bacteria, article from PNAS, Sept. 2008: http://www.pnas.org/content/105/39/14747.full | ||
*Database of Membrane Protein Structures: http://blanco.biomol.uci.edu/Membrane_Proteins_xtal.html | *Database of Membrane Protein Structures: http://blanco.biomol.uci.edu/Membrane_Proteins_xtal.html | ||
*[http://www.ncbi.nlm.nih.gov/pubmed/15251227 Bible] of GPCR mechanisms. | |||
==Questions== | ==Questions== | ||
*I would highly recommend looking through George Georgiou's literature to see what engineered parts he has made. - Chris | *I would highly recommend looking through George Georgiou's literature to see what engineered parts he has made. - Chris | ||
Revision as of 18:28, 3 May 2009
Summary
Comments and Discussion
- Can we identify a specific GPCR or class of GPCRs that we are interested in manipulating?
- Which host organism would make the best chassis?
- What should our GPCR be sensitive to?
Papers
- "Characterization of Engineered Channelrhodopsin Variants with Improved Properties and Kinetics," article from Biophysical Journal, March 2009: http://www.cell.com/biophysj/fulltext/S0006-3495(09)00016-2
- Engineering G protein-coupled receptor expression in bacteria, article from PNAS, Sept. 2008: http://www.pnas.org/content/105/39/14747.full
- Database of Membrane Protein Structures: http://blanco.biomol.uci.edu/Membrane_Proteins_xtal.html
- Bible of GPCR mechanisms.
Questions
- I would highly recommend looking through George Georgiou's literature to see what engineered parts he has made. - Chris
