IGEM:Tianjin/2007/

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TJU Team One

Introduction

With the great passion, innovative ideas and team work spirit, students from Tianjin University Team 1 are actively participating in this competition. We explain the iGEM competition as an international platform to show our great passion, energetic, most creative. Sound financial and technological strength is what we rely on to do a good job in this competition. We all have great power and are filled with confidence. Just to say “Go on, we will succeed”.

Team members:

Supervisors:

Prof. Yuan Yingjin Dr. Cheng Jingsheng Dr. Song Kai

Advisors

Li Bingzhi: PhD student majoring in Biochemical Engineering. Wang Honglei: Graduate student majoring in Chemical Engineering. Hu Bo: Graduate student majoring in Biochemical Engineering. Wang Xing: Graduate student majoring in pharmaceutical Engineering. Zhou Jian: Graduate student majoring in pharmaceutical Engineering. Shi Lei: Graduate student majoring in Biochemical Engineering.

Team Members

Sun jingjing: Senior undergraduate majoring in Bioengineering. Li Xiaoqian: Senior undergraduate majoring in Bioengineering. Zhu Manli: Senior undergraduate majoring in Bioengineering. Zou ruiyang: Senior undergraduate majoring in Molecular Science and Technology. Qiao Kangjian: Senior undergraduate majoring in Chemical Engineering. Chen Zheng: Senior undergraduate majoring in Chemical Engineering.

Lab and Funding

Prof. YJ Yuan kindly provides experiment environment and most of the financial support. Also our team gets the financial support from the National Natural Science Foundation of China and the Tianjin University.

Primary proposals:

Synthetic Biology related technology

• Logic gate(AND,OR,NOT,NAND,NOR,XOR):We combine some of them to construct several devices, such as DOUBLE CONTROL SWITCH, NUMERUS COMPARATOR, INCONSISTENT CIRCUIT, SR FLIP FLOP, ENCODER, CLOCK, much of them come from the electrocircuit consideration.
• Simulate reversible reaction: We try to simulate the reversible reaction with considering the impact of catalyzer, temperature, concentration and pressure. To use two fluorescence reporters, we can monitor the reaction direction by the colour varying.
• System controlling lytic/ lysogenic states: By cell-to-cell communication, we try to construct a system that a signal from a cell can control the lytic/ lysogenic states of cell infected by phage and using different reporter according to the different state.
• As we all know, time delay is very common in biology system. Is there some method that we can take use of this time delay? So we can use it to all the situations change is needed.

Because biological system is unpredictable and couldn’t control strictly as electrocircuit, there are still many problems we must face. We proceed with all the ideas but focus on the most feasible.

Other inspiration

Besides the logic application in our biological machine, we also hope to find other inspiration in energy and medicine issues. Surely, we get closer and closer to the final project.