IGEM:VGEM/2007/Projects

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*[http://www.ncbi.nlm.nih.gov/sites/entrez ''The ethylene gas signal transduction pathway: a molecular perspective'' by Johnson PR, Ecker JR.]
*[http://www.ncbi.nlm.nih.gov/sites/entrez ''The ethylene gas signal transduction pathway: a molecular perspective'' by Johnson PR, Ecker JR.]
*[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11337414&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum ''Molecular biology of fruit maturation and ripening'' by Giovannoni J.]
*[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11337414&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum ''Molecular biology of fruit maturation and ripening'' by Giovannoni J.]
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*[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9560288 ''Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors'' by Karen L. Clark]
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*[http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1692356&blobtype=pdf ''The ethylene-receptor family from Arabidopsis structure and function'' by Anthony B. Bleecker]
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*[http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17224067 ''A strong constitutive ethylene-response phenotype conferred on Arabidopsis plants containing null mutations in the ethylene receptors ETR1 and ERS1'' by Xiang Qu]
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*[http://www.bioone.org/perlserv/?request=get-document&doi=10.1199%2Ftab.0071#I1543-8120-12-1-1-F06 ''The Arabidopsis Book'' by G. Eric Schaller]
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===Synthetic Biological Clock===
===Synthetic Biological Clock===

Revision as of 09:24, 12 June 2007

Contents

Projects

The following project descriptions are of systems that we will attempt to construct this summer. Additional project ideas may be added in the near future.


Bacterial Melanogenesis



This project is an extension of work that was done at Biosource Genetics Corporation in 1990. What we would like to do is program bacteria to produce melanin in response to a red light stimulus. This inducible melanin production has various applications including making melanin for monitoring cellular processes. In this way, melanin would serve as a biomarker or indicator similar to the GFP but would be easily visible to the naked eye.

References


Ethylene Biosensor


During one of our brainstorming sessions we were discussing possible biosensors and came up with a fairly practical project idea: an ethylene biosensor. Why sense ethylene? Mature fruit produce and release ethylene as they ripen. Measuring the concentration of gaseous ethylene on or near the surface of the ripening fruit would allow for the indirect measurement of its degree of ripeness.

References


Synthetic Biological Clock


The synthetic biological clock was one of our earliest project ideas and involves the coupling of Elowitz and Leibler's repressilator system to some actuator such as fluorescence or aroma generation. We would like to link MIT's 2006 iGEM project to the repressilator and create an aroma therapy clock in addition to linking green, yellow and red fluorescent proteins to the repressilator to make a molecular traffic light. Future applications of controlled synthetic oscillatory systems include internal, autonomous drug delivery technology.

References

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