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(From: Front Microbiol. 2013; 4: 5. Published online 2013 January 25. doi: 10.3389/fmicb.2013.00005 An illustration of the accumulation of damaged genetic safeguards in a population of synthetic organisms. When cells with intact safeguards (blue) escape p)
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Revision as of 15:35, 4 March 2013

From: Front Microbiol. 2013; 4: 5. Published online 2013 January 25. doi: 10.3389/fmicb.2013.00005

An illustration of the accumulation of damaged genetic safeguards in a population of synthetic organisms. When cells with intact safeguards (blue) escape physical containment (e.g., an accidental spill), an inducer (i) can be added to remove them from the environment (see Figure ​Figure1C).1C). As the population grows, leaky expression of the lethal protein (−) reduces the viability of cells that carry functional safeguards. Mutation (X) of the lethal gene provides a growth advantage, thus cells that carry damaged safeguards (red) overwhelm the population. Cells with mutated safeguards do not respond to the cell death inducer (i). Consequently, it is difficult to remove the cells from the environment after an accidental release.

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15:35, 4 March 2013630×497 (83 KB)Thomas Wall (Talk | contribs) (From: Front Microbiol. 2013; 4: 5. Published online 2013 January 25. doi: 10.3389/fmicb.2013.00005 An illustration of the accumulation of damaged genetic safeguards in a population of synthetic organisms. When cells with intact safeguards (blue) escape p)

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