# Intertech:iSB2008:Materials

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 Revision as of 08:30, 28 May 2008 (view source)← Previous diff Revision as of 09:41, 28 May 2008 (view source)Next diff → Line 148: Line 148: ''' Basic Synthetic Biology Circuits''' ''' Basic Synthetic Biology Circuits''' - (based on the [http://openwetware.org/wiki/Imperial_College/Courses/Spring2008/Synthetic_Biology/Computer_Modelling_Practicals Computer Modelling Practicals] lecture by V. Rouilly at Imperial college) + (based on the [http://openwetware.org/wiki/Imperial_College/Courses/Spring2008/Synthetic_Biology/Computer_Modelling_Practicals Computer Modelling Practicals] lecture by Vincent Rouilly at Imperial College)

## Revision as of 09:41, 28 May 2008

introduction to Synthetic Biology 2008

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## Syllabus

Syllabus of this course is divided in three parts. There is a group of topics that need to be known by biologists (or 'life science' people), then a bunch of topics that need to be known by engineers (or 'technical' people) and, finally, some lectures on 'what' is syntehtic biology and some examples of it.

Please note that all these slides are released under Creative Commons BY-SA

 Part 1 Training for biologists Introduction Basic concepts to understand an ODE Description and properties of ODE Solving ODE Vector spaces Dynamic systems Introduction Types od controllers Block diagram Example of control Laplace transform and transfer function Frequency domain Examples Introduction Boolean algebras Logical gates Representation of boolean functions Karnaugh maps Introduction to measurement theory Error theroy description Types of errors Evaluation of the error in an experimental measurement Minimal square fit Obtaining relations from experimental data Introduction to programming languages Basic MatLab operations Programming in Matlab Solving ODE with Matlab Part 2 Training for engineers Cell, definition Basic elements Eukaryotes Prokaryotes Metabolism Elements Nucelic acid – DNA and RNA Amino acid – proteins Central Dogma of Molecular Biology Dogma, revisited Horizontal transference DNA regulation RNA regulation Protein regulation Global regulatory mechanisms: Signal transduction Signal Receptor Transducer Actuator Examples Definitions Law of mass action Enzyme-catalyzed reactions Hill equation: allosterism Hill equation in gene modelling DNA cloning Polymerase Chain Reaction Gel electrophoresis Reading and writing DNA Molecular hybridization rewriting DNA: mutations arrays

Part 3 Training in Synthetic Biology

 Introduction Synthetic Biology evolution Some examples Biology and Engineering: the paradigm of Synthetic biology Systems Biology work Synthetic gene regulatory systems Building a composable DNA library Registry Parts Signal carrier Modularity Looking for abstraction Abstraction hierarchy Basic Synthetic Biology Circuits (based on the Computer Modelling Practicals lecture by Vincent Rouilly at Imperial College) Toggle switch Repressilator Counting machine - ETH iGEM 2005 Memory device - ETH iGEM 2007 Cell free system - Imperial iGEM 2007 Synthetic pattern formation Artifitial quorum sensing Artemisinin production