JHIBRG:Abstract Dec 7 2006

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Abstract

runx2 has been suggested to play a major role in osteogenesis. Multiple research cite on its implication in the differentiation of the biopotential precursor cell to osteoblast. Some evidence hint its role also in controlling the differentiation from multipotential mesenchymal cell to biopotential precursor cell as well. Haploinsufficiency of runx2 was shown to cause Cleidocranial dysostosis, and runx2 knock-out mouse exhibit complete loss of bone formation.

Promoter analysis within a limited region of runx2 was insufficient in explaining the spatiotemporal expression pattern. A recent method based on conservation of non-coding elements [1] was applied to search for novel functional regulatory (enhancer) elements.

References

• Schroeder et al. Runx2: a master organizer of gene transcription in developing and maturing osteoblasts. Birth Defects Res C Embryo Today. 75:213 (2005)

• Otto et al. Control of RUNX2 isoform expression: the role of promoters and enhancers. J Cell Biochem. 95:506-17 (2005)

• Fisher et al. Conservation of RET regulatory function from human to zebrafish without sequence similarity Science 312:276 (2006)