JHIBRG:Abstract September 9 2007

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As a cytoskeleton, intermediate filaments (IF) provide cells with scaffold to other proteins as well as mechanical resistance from environmental trauma. Among IF proteins, keratins have unique features including hetero-dimer formation and specific expression in epithelia.
As a cytoskeleton, intermediate filaments (IF) provide cells with scaffold to other proteins as well as mechanical resistance from environmental trauma. Among IF proteins, keratins have unique features including hetero-dimer formation and specific expression in epithelia.
Functional importance of keratins has been envisioned by studying keratin-related disease such as Epidermolysis Bulosa Simplex, a skin blistering disorder due to keratin mutations. To study function and disease mechanism, structure/function reationship of keratin would be very useful. This talk will outline structural tools in biology and show how structural biology can be applied to study keratins.
Functional importance of keratins has been envisioned by studying keratin-related disease such as Epidermolysis Bulosa Simplex, a skin blistering disorder due to keratin mutations. To study function and disease mechanism, structure/function reationship of keratin would be very useful. This talk will outline structural tools in biology and show how structural biology can be applied to study keratins.
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Revision as of 09:01, 28 August 2007

As a cytoskeleton, intermediate filaments (IF) provide cells with scaffold to other proteins as well as mechanical resistance from environmental trauma. Among IF proteins, keratins have unique features including hetero-dimer formation and specific expression in epithelia. Functional importance of keratins has been envisioned by studying keratin-related disease such as Epidermolysis Bulosa Simplex, a skin blistering disorder due to keratin mutations. To study function and disease mechanism, structure/function reationship of keratin would be very useful. This talk will outline structural tools in biology and show how structural biology can be applied to study keratins.

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