Jacobs

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Welcome to the Cell and Molecular Biomechanics Lab at [http://www.columbia.edu Columbia University]!
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Welcome to the Cell and Molecular Biomechanics Lab at [http://www.columbia.edu Columbia University]! The CMBL is focused on determining the mechanism that allows cells to sense and respond to extracellular mechanical stimulation.  Particularly we are interested in determining, at a cellular level, how bone tissue is regulated by physical loading.  This work has applications in developing new therapies to age-related bone loss and osteoporosis.  We explore this question both in cell culture identifying novel molecular targets and in quantifying the skeletal sensitivity to loading of tissue-specific conditional deletions in mice.  Our current targets include focal adhesions, cytoskeletal proteins, and the cell's primary cilium.
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<font color=red>Currently under development.</font>
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==Recent updates to the lab wiki==
==Recent updates to the lab wiki==

Revision as of 13:49, 16 June 2008

Image:CMBL.jpg

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Welcome to the Cell and Molecular Biomechanics Lab at Columbia University! The CMBL is focused on determining the mechanism that allows cells to sense and respond to extracellular mechanical stimulation. Particularly we are interested in determining, at a cellular level, how bone tissue is regulated by physical loading. This work has applications in developing new therapies to age-related bone loss and osteoporosis. We explore this question both in cell culture identifying novel molecular targets and in quantifying the skeletal sensitivity to loading of tissue-specific conditional deletions in mice. Our current targets include focal adhesions, cytoskeletal proteins, and the cell's primary cilium.

Recent updates to the lab wiki


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