Jacobs

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Welcome to the Cell and Molecular Biomechanics Lab!  CMBL is part of the [http://bme.columbia.edu Department of Biomedical Engineering]  at [http://www.columbia.edu Columbia University]!  The CMBL is focused on determining the mechanism that allows cells to sense and respond to extracellular mechanical stimulation.  Particularly we are interested in determining, at a cellular level, how bone tissue is regulated by physical loading.  This work has applications in developing new therapies to age-related bone loss and osteoporosis.  We explore this question both in cell culture identifying novel molecular targets and in quantifying the skeletal sensitivity to loading of tissue-specific conditional deletions in mice.  Our current targets include focal adhesions, cytoskeletal proteins, and the cell's primary cilium.
 
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==News==
 
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*'''9/15/2009 The CMBL has an open [[Jacobs:Post-doctoral_fellowship_in_Stem_Cell_Biomechanics | post-doctoral fellowship]] in stem cell mechanobiology'''
 
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* '''9/1/2009 The CMBL receives New York State Stem Cell Grant'''
* '''9/1/2009 The CMBL receives New York State Stem Cell Grant'''
The CMBL was delighted to receive a three year grant to study the role of primary cilia in the ability of bone marrow derived stem cells to sense and respond to mechanical load.  The grant, titled "Mechanosensitive primary cilia in osteogenic differentiation of stem cells due to loading" if funded by the New York State Stem Cell Board ([http://stemcell.ny.gov/ NYSTEM]).  You can look at the lay abstract of the project [[Jacobs:NYSTEM abstract | here]].
The CMBL was delighted to receive a three year grant to study the role of primary cilia in the ability of bone marrow derived stem cells to sense and respond to mechanical load.  The grant, titled "Mechanosensitive primary cilia in osteogenic differentiation of stem cells due to loading" if funded by the New York State Stem Cell Board ([http://stemcell.ny.gov/ NYSTEM]).  You can look at the lay abstract of the project [[Jacobs:NYSTEM abstract | here]].

Revision as of 20:05, 19 January 2010

  • 9/1/2009 The CMBL receives New York State Stem Cell Grant

The CMBL was delighted to receive a three year grant to study the role of primary cilia in the ability of bone marrow derived stem cells to sense and respond to mechanical load. The grant, titled "Mechanosensitive primary cilia in osteogenic differentiation of stem cells due to loading" if funded by the New York State Stem Cell Board (NYSTEM). You can look at the lay abstract of the project here.

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