Jane Johnson Lab:Projects

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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes.  We are determining the cis-regulatory code and downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a.  In addition, we are tracing the lineage of these factors to assess the ultimate cell fate of the neural subtypes they specify.
We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes.  We are determining the cis-regulatory code and downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a.  In addition, we are tracing the lineage of these factors to assess the ultimate cell fate of the neural subtypes they specify.
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[[Image:JaneJohnsonLabMath1.jpg|thumb|LacZ expression in the Atoh1 domains]]<br>
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<gallery>
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[[Image:Nakada.png|thumb|GFP expression in the Neurog1 domains]]<br>
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[[Image:JaneJohnsonLabMath1.jpg|LacZ expression in the Atoh1 domains]]<br>
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[[Image:Battiste.png|thumb|LacZ expression in the Ascl1 domains]]<br>
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[[Image:Nakada.png|GFP expression in the Neurog1 domains]]<br>
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[[Image:Glasgow.png|thumb|LacZ expression in the Ptf1a domains]]<br>
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[[Image:Battiste.png|LacZ expression in the Ascl1 domains]]<br>
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[[Image:Glasgow.png|LacZ expression in the Ptf1a domains]]<br>
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<gallery>
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Revision as of 13:48, 9 February 2009

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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes. We are determining the cis-regulatory code and downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a. In addition, we are tracing the lineage of these factors to assess the ultimate cell fate of the neural subtypes they specify.

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