Jane Johnson Lab:Projects: Difference between revisions
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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes. We are determining the cis-regulatory code and downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a. In addition, we are tracing the lineage of these factors to assess the ultimate cell fate of the neural subtypes they specify. | We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes. We are determining the cis-regulatory code and downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a. In addition, we are tracing the lineage of these factors to assess the ultimate cell fate of the neural subtypes they specify. | ||
[[Image:JaneJohnsonLabMath1.jpg | <gallery> | ||
[[Image:Nakada.png | [[Image:JaneJohnsonLabMath1.jpg|LacZ expression in the Atoh1 domains]]<br> | ||
[[Image:Battiste.png | [[Image:Nakada.png|GFP expression in the Neurog1 domains]]<br> | ||
[[Image:Glasgow.png | [[Image:Battiste.png|LacZ expression in the Ascl1 domains]]<br> | ||
[[Image:Glasgow.png|LacZ expression in the Ptf1a domains]]<br> | |||
<gallery> | |||
Page is in progress... | Page is in progress... | ||
Revision as of 10:48, 9 February 2009
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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes. We are determining the cis-regulatory code and downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a. In addition, we are tracing the lineage of these factors to assess the ultimate cell fate of the neural subtypes they specify.
<gallery>
<gallery>
Page is in progress...
