Jane Johnson Lab:Projects

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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes.  We are determining the cis-regulatory code and downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a.  In addition, we are tracing the lineage of these factors to assess the ultimate cell fate of the neural subtypes they specify.
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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes.  We are determining the cis-regulatory code and downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a.  In addition, we are tracing the lineage of these factors to assess the ultimate cell fate of the neural subtypes they specify.<br>
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Image:Glasgow.png|LacZ expression in the Ptf1a domains
Image:Glasgow.png|LacZ expression in the Ptf1a domains
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Revision as of 13:49, 9 February 2009

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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes. We are determining the cis-regulatory code and downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a. In addition, we are tracing the lineage of these factors to assess the ultimate cell fate of the neural subtypes they specify.

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