Jane Johnson Lab:Projects

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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes.  We are determining the cis-regulatory code and downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a.  In addition, we are tracing the lineage of these factors to assess the ultimate cell fate of the neural subtypes they specify.<br>
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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes.  By determining the downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a, we hope to elucidate a cis-regulatory code for these transcription factors.  In addition, by lineage tracing these factors we hope to assess the ultimate cell fate of the neural subtypes they specify.<br>
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Revision as of 13:50, 9 February 2009

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We are investigating the role of basic helix-loop-helix (bHLH)transcription factors in differentiation and cell-type specification of neural subtypes. By determining the downstream targets of Atoh1, Neurog1/2, Ascl1, and Ptf1a, we hope to elucidate a cis-regulatory code for these transcription factors. In addition, by lineage tracing these factors we hope to assess the ultimate cell fate of the neural subtypes they specify.

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