Javidlab:labalumni: Difference between revisions

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[[Javidlab | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''Home''' </font>]] &nbsp;&nbsp;&nbsp;
[[Javidlab | <font face="trebuchet ms" size=4 style="color:#ffffff"> '''/  Home ''' </font>]]
[[Javidlab:research | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''Research''' </font>]] &nbsp;&nbsp;&nbsp;
[[Javidlab:news | <font face="trebuchet ms" size=4 style="color:#ffffff"> '''/  NEWS  ''' </font>]]
[[Javidlab:publications | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''Publications''' </font>]] &nbsp;&nbsp;&nbsp;
[[Javidlab:research | <font face="trebuchet ms" size=4 style="color:#ffffff"> '''/  Research ''' </font>]]
[[Javidlab:labmembers | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''Lab Members''' </font>]] &nbsp;&nbsp;&nbsp;
[[Javidlab:publications | <font face="trebuchet ms" size=4 style="color:#ffffff"> '''/  Publications ''' </font>]]
[[Javidlab:labalumni | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''Lab Alumni''' </font>]] &nbsp;&nbsp;&nbsp;
[[Javidlab:labmembers | <font face="trebuchet ms" size=4 style="color:#ffffff"> '''/  Lab Members ''' </font>]]
[[Javidlab:funstuff | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''Fun Stuff''' </font>]]&nbsp;&nbsp;&nbsp;
[[Javidlab:labalumni | <font face="trebuchet ms" size=4 style="color:#ffffff"> '''/  Lab Alumni ''' </font>]]
[[Javidlab:contact | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''Contact''' </font>]]
[[Javidlab:funstuff | <font face="trebuchet ms" size=4 style="color:#ffffff"> '''/  Fun Stuff ''' </font>]]
 
[[Javidlab:contact | <font face="trebuchet ms" size=4 style="color:#ffffff"> '''/  Contact /''' </font>]]
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<font face="trebuchet ms" size=5 style="color:#930000"> PI</font><br>
<font face="trebuchet ms" size=4 style="color:#CC0000">Former Postdocs</font><br>
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<font face="trebuchet ms" size=5 style="color:#000000">Babak Javid</font><br>
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Babak Javid is a physician scientist with an interest in tuberculosis, infectious diseases and protein translational fidelity.  He did his medical training in the UK, his PhD on antigen processing and presentation with Paul Lehner at Cambridge, and post-doctoral training on mycobacterial genetics with Eric Rubin at Harvard.  He joined Tsinghua School of Medicine in October 2011.<br><br>
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<font face="trebuchet ms" size=4 style="color:#000000">Email: </font>bjavid{at}gmail.com (Please replace {at} to @ in the address.)<br>
<font size=4>&nbsp;&nbsp;&nbsp;Flavia Sorrentino</font>
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Post-doc, UBC/ GSK
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<font face="trebuchet ms" size=4 style="color:#CC0000">Former Technicians/ Lab Managers</font><br>
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<font face="trebuchet ms" size=5 style="color:#930000">Postdocs</font><br>
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<font face="trebuchet ms" size=4 style="color:#000000"> Melody Toosky </font><br>
<font size=4>&nbsp;&nbsp;&nbsp;</font>'''NAME'''
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Post-doc, Tsinghua University, 2012- present;<br>
'''CURRENT POSITION'''
Ph.D., Microbiology and Immunology, University of North Dakota 2012;<br>
 
B.S., Biology, University of California, Irvine 2004;<br><br>
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Hobbies: Chinese language, culture, music and food<br>
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Email: mtoosky{at}gmail.com (Please replace {at} to @ in the address.)<br>
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<font size=4>&nbsp;&nbsp;&nbsp;Jess Pinkham</font>
Mycobacterial infections are characterized by the need of the host to contain the invading pathogen as well as by the need of the pathogen to escape the host cell in order to infect other cells.  An important phase during this interaction pertains to host cell death decision pathway.  My project involves looking at this pathway using proteomic tools to get some clues about how mycobacteria can influence the manner in which host cells die.;</div>
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Research associate, Harvard School of Public Health
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<font size=4>&nbsp;&nbsp;&nbsp;Jiaying Xue</font>
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Consultant
 
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<font size=4>&nbsp;&nbsp;&nbsp;Jingfei Xu</font>
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PhD student, CLS, Tsinghua University
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<font face="trebuchet ms" size=4 style="color:#CC0000">Former Undergraduate Thesis Students</font><br>
<font face="trebuchet ms" size=5 style="color:#930000">Graduate Students</font><br>
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<font face="trebuchet ms" size=4 style="color:#000000"> Zhu, Junhao 朱军豪</font><br>
Second-year Postgraduate Student (PTN Programme)<br>
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2011.09-present:  College of Life Science, Peking University, PhD;<br>
2007.09-2011.07: College of Life Science, Peking University ,Bachelor;<br>
<br>
Hobbies: basketball, painting and cooking<br>
E-mail address: newforlofe{at}gmail.com (Please replace {at} to @ in the address.)<br>
<br>
In a homogeneous bacterial population (identical in genomic information), the phenotypes of individual cells may vary significantly due to gene expression, protein synthesis  and other processes.  One reason for this  variation may be the rate of errors generated during protein synthesis (mistranslation), which we hypothesise may benefit cell survival when they are challenged by stress or antibiotics. I am designing novel reporters to measure mistranslation at the single cell level.  I hope to find what's controlling the heterogeneity of mistranslation in a clonal population and a potential clues for novel drug development.
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<font size=4>&nbsp;&nbsp;&nbsp;</font>'''NAME'''
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'''CURRENT POSITION'''
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<font face="trebuchet ms" size=4 style="color:#000000"> Su, Hongwei 苏宏伟</font><br>
First-year Postgraduate Student (PTN Programme)<br>
<br>
2012.09-present: College of Life Science, Tsinghua University, PhD;<br>
2007.09-2012.07: College of Animal Husbandry and Veterinary, Jilin university, Bachelor;<br>
<br>
Hobbies: basketball, and other sports, watching movies<br>
Email: suhongwei0108{at}gmail.com (Please replace {at} to @ in the address.)<br>
<br>
Based on previous work of the lab, mycobacteria could tolerate high mistranslation rates and this phenotype could help them to adapt to different kinds of environment including some antibiotic such as rifampicin. So there may be some specific elements which control translational fidelity.
My project is to find the genetic elements controlling mycobacterial translation fidelity using forward genetic screens.
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<font size=4>&nbsp;&nbsp;&nbsp;Nina Jain</font>
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MD-MBA student, Harvard MIT and Oxford
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<font face="trebuchet ms" size=4 style="color:#000000"> Cai, Rongjun 蔡荣俊</font><br>
First-year Postgraduate Student<br>
<br>
2012.09-present:  School of Medicine, Tsinghua University, PhD;<br>
2008.09-2012.07: College of Animal Sciences & Technology, Huazhong Agricultural University, Bachelor;<br>
<br>
Hobbies: computer techniques<br>
Email: kim32000{at}hotmail.com (Please replace {at} to @ in the address.)<br>
<br>
In mycobacteria tRNAAsn and tRNAGln are generated by a two-step synthesis, involving physiological misacylation to Glu-tRNAGln and Asp-tRNAAsn intermediates which are amidated to the cognate forms by GatCAB. I am focusing on the role of GatCAB in this indirect pathway to identify its potential link to relative mistranslation rate in mycobacteria. I am also interested in mechanisms to manipulate mycobacteria genetically including generation of SNPs via recombineering.
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<font size=4>&nbsp;&nbsp;&nbsp;Yuxian Du</font>
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PhD student, Texas A&M University
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<font face="trebuchet ms" size=4 style="color:#000000"> Long, Jing 龙晶</font><br>
First-year Postgraduate Student<br>
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2012.09-present: School of Medicine, Tsinghua University, PhD;<br>
<br>
Hobbies: photography, food<br>
<br>
My projects are based on the hypothesis that mistranslation may contribute to mycobacterial adaption to the intracellular environment. One of my projects is to verify the hypothesis by measuring the mycobacterial mistranslation rate before or after infection; the other one is to understand the interactions between the host and mycobacteria during the process of infection.
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<font face="trebuchet ms" size=4 style="color:#CC0000">Other Undergraduates/ summer interns</font><br>
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<font size=4>&nbsp;&nbsp;&nbsp;</font>'''NAME'''
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'''CURRENT POSITION'''


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<font face="trebuchet ms" size=4 style="color:#000000"> Xue, Jiaying 薛佳莹</font><br>
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Assistant / Lab manger<br>
<font size=4>&nbsp;&nbsp;&nbsp;Jonathan Foxwell</font>
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2011.07-present: School of medicine, Tsinghua University, Research assistant;<br>
PhD student, Oxford University
2008.09-2011.07: Shang Dong University, Graduate student;<br>
2004.08-2008.8: Ocean University of China, Bachelor degree;<br>
<br>
Hobbies: climbing, hiking<br>
Email: xuejiaying2006{at}hotmail.com (Please replace {at} to @ in the address.)<br>
<br>
My work is to make our lab run in an orderly and efficient manner. This includes procurement and management.  I also help Professor Babak Javid as his assistant, for example translation of documents between English and Chinese and generally making sure he doesn’t get into too much trouble.</div>
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<font size=4>&nbsp;&nbsp;&nbsp;Frankie Wong</font>
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<font face="trebuchet ms" size=4 style="color:#000000"> Li, Hao 李浩</font><br>
MD student, UCLA
Research Assistant<br>
<br>
2011.07-present: School of medicine, Tsinghua University, Research assistant;<br>
2008.09-2011.07: Academy of Military Medical Sciences, Graduate student;<br>
2004.08-2008.8: Henan Agricultural University, Bachelor degree;<br>
<br>
Hobbies: basketball, hiking, movies<br>
E-mail address: leehao{at}biomed.tsinghua.edu.cn (Please replace {at} to @ in the address.)<br>
<br>
The Main research field: The interaction of Mycobacterial with the host.<br>
Projects:<br>
1: Research on the protein Trehalose-6-phosphate Phosphatase (OtsB2) from Mycobacterium tuberculosis.<br>
2: Research on antigen presentation during mycobacterial infection.<br>
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<font size=4>&nbsp;&nbsp;&nbsp;Sian Williams</font>
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Technology Consultant


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<font face="trebuchet ms" size=4 style="color:#000000"> Pan, Miaomiao 潘苗苗</font><br>
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Research Assistant<br>
<font size=4>&nbsp;&nbsp;&nbsp;Xia Wu</font>
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2012.07-present: School of medicine, Tsinghua University, Research assistant;<br>
Medical student, PUMC
2009.09-2012.07: Nankai University, Master degree;<br>
2005.09-2009.07: Shaanxi University of Technology, Bachelor degree.<br>
<br>
Hobbies: reading, watching movies, climbing and sleeping<br>
E-mail address: panmm99{at}gmail.com (Please replace {at} to @ in the address.)<br>
<br>
I am interested in the hypothesis that a high phenotypic drug resistance in mycobacteria species is caused by high adaptive mistranslation. I am currently developing a gain of function reporter to measure the mistranslation rate using a M. smegmatis model. I will use this reporter assay to screen drugs in order to find hits which can decrease mycobacteria mistranslation. My ultimate goal is to decrease the phenotypic drug resistance of Mycobacteria tuberculosis. My hobbies are.</div>
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<font size=4>&nbsp;&nbsp;&nbsp;Shaohan Wu</font>
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Undergraduate, China Agricultural University
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<font face="trebuchet ms" size=4 style="color:#000000"> Du, Yuxian 杜禹贤</font><br>
Senior Undergraduate Student (Tsinghua University)<br>
<br>
Hobbies: calligraphy, poem recitation performance, singing, and sports.<br>
Emali: bobthu09{at}gmail.com (Please replace {at} to @ in the address.)<br>
<br>
My project focuses on the dynamics of macrophage surface proteins following mycobacterial infection. Mycobacteria have co-evolved with its host, macrophages, so that they are fully adapted to living inside this effector cell of the innate immune system. Many changes to surface proteins occur following infection but it is unclear whether these changes represent host responses to infection, or mycobacterial adaptations to the host – subverting the host machinery for their own needs. Further experiments will attempt to answer these questions.</div>
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<font size=4>&nbsp;&nbsp;&nbsp;Veronica Su</font>
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PhD student, The Hong Kong University of Science & Technology
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<font face="trebuchet ms" size=4 style="color:#000000"> Leng, Tianqi 冷天祺</font><br>
Junior Undergraduate Student (Peking University)<br>
<br>
Hobbies: Marvel superhero movies, swimming, table tennis and badminton.<br>
Email: lengtq{at}gmail.com (Please replace {at} to @ in the address.)<br>
<br>
My project investigates the repertoire and rate of mycobacterial mistranslation in the model organism Mycobacterium smegmatis.  I will use gain of function luminescence reporters to accurately identify the rate of many different types of translational error.
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<font size=4>&nbsp;&nbsp;&nbsp;Zheng Hua</font>
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Medical student, PUMC


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<font size=4>&nbsp;&nbsp;&nbsp;Da-Ya Lee</font>
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Undergraduate, Smith College


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<font face="trebuchet ms" size=4 style="color:#000000"> He, Qiao 贺桥</font><br>
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Junior Undergraduate Student (Peking University)<br>
<font size=4>&nbsp;&nbsp;&nbsp;Dilara Akcal</font>
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Hobbies: Surfing Internet, playing basketball, reading<br>
Medical student, Ankara University
Email: rodefo{at}gmail.com (Please replace {at} to @ in the address.)<br>
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I am interested in using fluorescent reporters to measure mycobacterial mistranslation rates.
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<font face="trebuchet ms" size=4 style="color:#CC0000">High School Interns</font><br>
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<font size=4>&nbsp;&nbsp;&nbsp;Kaiji Wang</font>
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Biomedical Sciences student, Imperial College


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<font size=4>&nbsp;&nbsp;&nbsp;Saba Changizi</font>
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High school student, Harrow School Beijing
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<font face="trebuchet ms" size=2 style="color:#000079">LAST UPDATED November 2013</font><br><br>
<font face="trebuchet ms" size=4 style="color:#000000"> Chen, Yanan 陈亚男</font><br>
Senior Undergraduate Student (Nanjing Agricultural University)<br>
<br>
Hobbies: Korean language, reading novels<br>
Email: chenyanan90618{at}163.com (Please replace {at} to @ in the address.)<br>
<br>
I am investigating the role of EF-Tu discrimination in mycobacterial mistranslation, which will examine one potential mechanism for mycobacterial mistranslation. The residing dogma states that misacylated tRNAs cannot take part in protein translation due to discrimination by EF-Tu, but this has not been investigated in vivo. <br>
We know that fidelity in translation is associated with two key events: synthesis of correctly charged aminoacyl transfer RNAs (aa-tRNAs) by aminoacyl tRNA synthetases (aaRSs) and accurate selection of aa-tRNAs by the ribosome.  However, the precise molecular mechanism of mycobacterial mistranslation is poorly understood.
Specifically, it is not known if mistranslation results from errors of ribosomal decoding or misacylation of amino-acylated tRNAs. This is particularly relevant since mycobacteria physiologically misacylate glutamine and asparagine tRNAs before modifying them to the correct form by the action of the enzyme GatCAB.
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Revision as of 18:48, 3 March 2014




Former Postdocs

   NAME

CURRENT POSITION

   Flavia Sorrentino

Post-doc, UBC/ GSK



Former Technicians/ Lab Managers

   NAME

CURRENT POSITION

   Jess Pinkham

Research associate, Harvard School of Public Health

   Jiaying Xue

Consultant

   Jingfei Xu

PhD student, CLS, Tsinghua University



Former Undergraduate Thesis Students

   NAME

CURRENT POSITION

   Nina Jain

MD-MBA student, Harvard MIT and Oxford

   Yuxian Du

PhD student, Texas A&M University



Other Undergraduates/ summer interns

   NAME

CURRENT POSITION

   Jonathan Foxwell

PhD student, Oxford University

   Frankie Wong

MD student, UCLA

   Sian Williams

Technology Consultant

   Xia Wu

Medical student, PUMC

   Shaohan Wu

Undergraduate, China Agricultural University

   Veronica Su

PhD student, The Hong Kong University of Science & Technology

   Zheng Hua

Medical student, PUMC

   Da-Ya Lee

Undergraduate, Smith College

   Dilara Akcal

Medical student, Ankara University


High School Interns

   NAME

CURRENT POSITION

   Kaiji Wang

Biomedical Sciences student, Imperial College

   Saba Changizi

High school student, Harrow School Beijing


LAST UPDATED November 2013

Room 4-302 Biotech Building
School of Medicine
Tsinghua University

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