Javidlab:labmembers: Difference between revisions

From OpenWetWare
Jump to navigationJump to search
No edit summary
mNo edit summary
 
(27 intermediate revisions by the same user not shown)
Line 1: Line 1:
<center>
<center>
<div style="background-color: #F0F0F0">
<font face="Georgia">
<br>
<br>
<br>
<br>
{|
 
|-
{| cellspacing="0"
||
|- valign="center"
<font face="Georgia">
|style="clear: right; text-align: center; float: none; width: 640px"|
[[Image:THUMTB-LOGO3.png|640px]]
|style="clear: right; text-align: right; float: none; width: 295px"|
'''Room 4-304 Biotech Building'''<br>
'''School of Medicine, Tsinghua University'''<br>
|style="clear: right; text-align: right; float: none; width: 5px"|
|style="clear: right; text-align: left; float: none; width: 60px"|
[[Image:THU-LOGO.png|60px]]
|}
 
{| cellspacing="0"
{| cellspacing="0"
|- valign="center"
|- valign="center"
|width="80%"|
<div style="clear: right; text-align: center; float: none">
[[Image:THUMTB-LOGO2.png|800px]]
<div style="color: #ffffff; background-color: #750000; width: 800px;">
[[Javidlab | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''Home''' </font>]] &nbsp;&nbsp;&nbsp;
[[Javidlab:news | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''NEWS''' </font>]] &nbsp;&nbsp;&nbsp;
[[Javidlab:research | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''Research''' </font>]] &nbsp;&nbsp;&nbsp;
[[Javidlab:publications | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''Publications''' </font>]] &nbsp;&nbsp;&nbsp;
[[Javidlab:labmembers | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''Lab Members''' </font>]] &nbsp;&nbsp;&nbsp;
[[Javidlab:labalumni | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''Lab Alumni''' </font>]] &nbsp;&nbsp;&nbsp;
[[Javidlab:funstuff | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''Fun Stuff''' </font>]]&nbsp;&nbsp;&nbsp;
[[Javidlab:contact | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''Contact''' </font>]]


</div>
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000079; text-align: center; padding: 0em 0em 0em 0em"|
</div>
[[Javidlab | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''HOME''' </font>]]
|width="20%"|
|style="width: 2px; height: 10px"|
<div style="clear: right; text-align: left; float: none; width: 200px">
 
[[Image:THUMTB-HOME3.GIF|200px]]
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000081; text-align: center; padding: 0em 0em 0em 0em"|
</div>
[[Javidlab:news | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''NEWS''' </font>]]
|style="width: 2px; height: 10px"|
 
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000083; text-align: center; padding: 0em 0em 0em 0em"|
[[Javidlab:research | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''Research''' </font>]]
|style="width: 2px; height: 10px"|
 
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000085; text-align: center; padding: 0em 0em 0em 0em"|
[[Javidlab:publications | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''Publication''' </font>]]
|style="width: 2px; height: 10px"|
 
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000087; text-align: center; padding: 0em 0em 0em 0em"|
[[Javidlab:labmembers | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''Members''' </font>]]
|style="width: 2px; height: 10px"|
 
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000089; text-align: center; padding: 0em 0em 0em 0em"|
[[Javidlab:labalumni | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''Alumni''' </font>]]
|style="width: 2px; height: 10px"|
 
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000091; text-align: center; padding: 0em 0em 0em 0em"|
[[Javidlab:funstuff | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''Fun''' </font>]]
|style="width: 2px; height: 10px"|
 
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000093; text-align: center; padding: 0em 0em 0em 0em"|
[[Javidlab:contact | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''Contact''' </font>]]
|style="width: 2px; height: 10px"|
 
|}
|}
<br>
<div style="text-align: left">
<font face="trebuchet ms" size=5 style="color:#930000"> PI</font><br>
<div style="color: #000000; background-color: #FFFFFF; width: 1000px;">
----
</div><br>


<div style="width:1000px" >
{| cellspacing="0"
|- valign="top"
|width="20%"|
<div style="text-align: left;>
[[Image:THUMTB-BJ.jpg|200px]]
</div>
|width="70%"|
<div style="text-align: left;>
<font face="trebuchet ms" size=5 style="color:#000000">Babak Javid</font><br>
<br>
Babak Javid is a physician scientist with an interest in tuberculosis, infectious diseases and protein translational fidelity.  He did his medical training in the UK, his PhD on antigen processing and presentation with Paul Lehner at Cambridge, and post-doctoral training on mycobacterial genetics with Eric Rubin at Harvard.  He joined Tsinghua School of Medicine in October 2011.<br><br>
<font face="trebuchet ms" size=4 style="color:#000000">Email: </font>bjavid{at}gmail.com (Please replace {at} to @ in the address.)<br>
<br>
<br>
<br>
</div>
|}
</div>


{| cellspacing="0"
|- valign="top"
|width="100px"|
[[Image:THUMTB-M-PI.png|100px]]
|width="200px"|
[[Image:THUMTB-BJ.jpg|200px]]
|style="width: 700px; padding: 1em 1em 1em 1em"|
<div style="text-align: left;>
<font face="trebuchet ms" size=4 style="color:#000000">Babak Javid</font><br>
<br>
Babak Javid is a physician scientist with an interest in tuberculosis, infectious diseases and protein translational fidelity.  He did his medical training in the UK, his PhD on antigen processing and presentation with Paul Lehner at Cambridge, and post-doctoral training on mycobacterial genetics with Eric Rubin at Harvard.  He joined Tsinghua School of Medicine in October 2011.<br><br>
<font face="trebuchet ms" size=4 style="color:#000000">Email: </font>bjavid{at}gmail.com (Please replace {at} to @ in the address.)<br>
</div>
|}<br>


<br>
<font face="trebuchet ms" size=5 style="color:#930000">Postdocs</font><br>
<div style="color: #000000; background-color: #FFFFFF; width: 1000px;">
<div style="color: #000000; background-color: #FFFFFF; width: 1000px;">
----
----
</div><br>
</div><br>


<div style="width:1000px" >
{| cellspacing="0"
{| cellspacing="0"
|- valign="top"
|- valign="top"
|width="100px"|
|width="70%"|
[[Image:THUMTB-M-POSTDOCs.png|100px]]
<div style="text-align: left;>
|width="200px"|
<font face="trebuchet ms" size=4 style="color:#000000"> Melody Toosky </font><br>
[[Image:THUMTB-MT.png|200px]]
<br>
|style="width: 700px; padding: 1em 1em 1em 1em"|
Post-doc, Tsinghua University, 2012- present;<br>
<div style="text-align: left;>
Ph.D., Microbiology and Immunology, University of North Dakota 2012;<br>
<font face="trebuchet ms" size=4 style="color:#000000"> Melody Toosky </font><br>
B.S., Biology, University of California, Irvine 2004;<br><br>
<br>
Hobbies: Chinese language, culture, music and food<br>
Post-doc, funded by the Gates Foundation, Harvard Chan School of Public Health, USA, 2014- present;<br>
Email: mtoosky{at}gmail.com (Please replace {at} to @ in the address.)<br>
Post-doc, Tsinghua University, 2012- 2014;<br>
<br>
Ph.D., Microbiology and Immunology, University of North Dakota 2012;<br>
Mycobacterial infections are characterized by the need of the host to contain the invading pathogen as well as by the need of the pathogen to escape the host cell in order to infect other cells.  An important phase during this interaction pertains to host cell death decision pathway.  My project involves looking at this pathway using proteomic tools to get some clues about how mycobacteria can influence the manner in which host cells die.;</div>
B.S., Biology, University of California, Irvine 2004;<br><br>
|width="20%"|
Hobbies: Chinese language, culture, music and food<br>
<div style="text-align: left;>
Email: mtoosky{at}gmail.com (Please replace {at} to @ in the address.)<br>
[[Image:THUMTB-MT.png|200px]]
<br>
</div>
Mycobacterial infections are characterized by the need of the host to contain the invading pathogen as well as by the need of the pathogen to escape the host cell in order to infect other cells.  An important phase during this interaction pertains to host cell death decision pathway.  My project involves looking at this pathway using proteomic tools to get some clues about how mycobacteria can influence the manner in which host cells die.</div>
|}
|}<br>
</div>


<br>
{| cellspacing="0"
<font face="trebuchet ms" size=5 style="color:#930000">Graduate Students</font><br>
|- valign="top"
|width="100px"|
[[Image:THUMTB-M-POSTDOCs.png|100px]]
|width="200px"|
[[Image:THUMTB-SWAR.JPG|200px]]
|style="width: 700px; padding: 1em 1em 1em 1em"|
<div style="text-align: left;>
<font face="trebuchet ms" size=4 style="color:#000000"> Swarnava Chaudhuri </font><br>
<br>
Post-doc, Tsinghua University, 2014-present;<br>
Post-doc, Meharry Medical College, 2013-2014;<br>
Post-doc, University of California, Santa Barbara, 2011-2012;<br>
Ph.D, Microbiology & Immunology, University of Illinois at Chicago, 2011;<br>
M.Sc, Biochemistry, University of Calcutta, 2005;<br>
B.Sc, Microbiology, University of Calcutta, 2003;<br><br>
Hobbies: Travelling, photography, reading<br>
Email: swarnavachau{at}yahoo.com (Please replace {at} to @ in the address.)<br>
<br>
The prolonged antibiotic regime during treatment of tuberculosis is a serious healthcare burden. The long treatment period for tuberculosis results from rifampicin tolerance in Mycobacteria. Reduced translational fidelity, which results in the formation of mistranslated protein variants, is a key mechanism behind rifampicin tolerance in mycobacteria. My project is to identify drugs that increase the translational fidelity in mycobacteria, and thereby make the bacterium more susceptible to rifampicin。The other part of my project is to identify the mechanism by which these drugs increase translational fidelity in mycobacteria.</div>
|}<br>
<div style="color: #000000; background-color: #FFFFFF; width: 1000px;">
<div style="color: #000000; background-color: #FFFFFF; width: 1000px;">
----
----
</div><br>
</div><br>


<div style="width:1000px" >
{| cellspacing="0"
{| cellspacing="0"
|- valign="top"
|- valign="top"
|width="100px"|
|width="20%"|
[[Image:THUMTB-M-Graduates.png|100px]]
<div style="text-align: left;>
|width="200px"|
[[Image:THUMTB-ZJH.jpg|200px]]
[[Image:THUMTB-ZJH.jpg|200px]]
</div>
|style="width: 700px; padding: 1em 1em 1em 1em"|
|width="70%"|
<div style="text-align: left;>
<div style="text-align: left;>
<font face="trebuchet ms" size=4 style="color:#000000"> Zhu, Junhao 朱军豪</font><br>
<font face="trebuchet ms" size=4 style="color:#000000"> Zhu, Junhao 朱军豪</font><br>
Fifth-year Postgraduate Student (PTN Programme)<br>
Third-year Postgraduate Student (PTN Programme)<br>
<br>
<br>
2011.09-present:  College of Life Science, Peking University, PhD;<br>
2011.09-present:  College of Life Science, Peking University, PhD;<br>
2007.09-2011.07: College of Life Science, Peking University ,Bachelor;<br>
2007.09-2011.07: College of Life Science, Peking University ,Bachelor;<br>
<br>
<br>
Hobbies: basketball, painting and cooking<br>
Hobbies: basketball, painting and cooking<br>
E-mail address: newforlofe{at}gmail.com (Please replace {at} to @ in the address.)<br>
E-mail address: newforlofe{at}gmail.com (Please replace {at} to @ in the address.)<br>
<br>
<br>
In a homogeneous bacterial population (identical in genomic information), the phenotypes of individual cells may vary significantly due to gene expression, protein synthesis  and other processes.  One reason for this  variation may be the rate of errors generated during protein synthesis (mistranslation), which we hypothesise may benefit cell survival when they are challenged by stress or antibiotics. I am designing novel reporters to measure mistranslation at the single cell level.  I hope to find what's controlling the heterogeneity of mistranslation in a clonal population and a potential clues for novel drug development.
In a homogeneous bacterial population (identical in genomic information), the phenotypes of individual cells may vary significantly due to gene expression, protein synthesis  and other processes.  One reason for this  variation may be the rate of errors generated during protein synthesis (mistranslation), which we hypothesise may benefit cell survival when they are challenged by stress or antibiotics. I am designing novel reporters to measure mistranslation at the single cell level.  I hope to find what's controlling the heterogeneity of mistranslation in a clonal population and a potential clues for novel drug development.
</div>
;</div>
|}<br>
|}
<br>
</div>


<div style="width:1000px" >
{| cellspacing="0"
{| cellspacing="0"
|- valign="top"
|- valign="top"
|width="100px"|
|width="20%"|
[[Image:THUMTB-M-Graduates.png|100px]]
<div style="text-align: left;>
|width="200px"|
[[Image:THUMTB-SHW.jpg|200px]]
[[Image:THUMTB-SHW.jpg|200px]]
</div>
|style="width: 700px; padding: 1em 1em 1em 1em"|
|width="70%"|
<div style="text-align: left;>
<div style="text-align: left;>
<font face="trebuchet ms" size=4 style="color:#000000"> Su, Hongwei 苏宏伟</font><br>
<font face="trebuchet ms" size=4 style="color:#000000"> Su, Hongwei 苏宏伟</font><br>
Fourth-year Postgraduate Student (PTN Programme)<br>
Second-year Postgraduate Student (PTN Programme)<br>
<br>
<br>
2012.09-present: College of Life Science, Tsinghua University, PhD;<br>
2012.09-present: College of Life Science, Tsinghua University, PhD;<br>
2007.09-2012.07: College of Animal Husbandry and Veterinary, Jilin university, Bachelor;<br>
2007.09-2012.07: College of Animal Husbandry and Veterinary, Jilin university, Bachelor;<br>
<br>
<br>
Hobbies: basketball, and other sports, watching movies<br>
Hobbies: basketball, and other sports, watching movies<br>
Email: suhongwei0108{at}gmail.com (Please replace {at} to @ in the address.)<br>
Email: suhongwei0108{at}gmail.com (Please replace {at} to @ in the address.)<br>
<br>
<br>
Based on previous work of the lab, mycobacteria could tolerate high mistranslation rates and this phenotype could help them to adapt to different kinds of environment including some antibiotic such as rifampicin. So there may be some specific elements which control translational fidelity.
Based on previous work of the lab, mycobacteria could tolerate high mistranslation rates and this phenotype could help them to adapt to different kinds of environment including some antibiotic such as rifampicin. So there may be some specific elements which control translational fidelity.
My project is to find the genetic elements controlling mycobacterial translation fidelity using forward genetic screens.  
My project is to find the genetic elements controlling mycobacterial translation fidelity using forward genetic screens.  
</div>
;</div>
|}<br>
|}
<br>
</div>


<div style="width:1000px" >
{| cellspacing="0"
{| cellspacing="0"
|- valign="top"
|- valign="top"
|width="100px"|
|width="20%"|
[[Image:THUMTB-M-Graduates.png|100px]]
<div style="text-align: left;>
|width="200px"|
[[Image:THUMTB-CRJ.JPG|200px]]
<div style="text-align: left;>
</div>
[[Image:THUMTB-CRJ2.jpg|200px]]
|width="70%"|
</div>
<div style="text-align: left;>
|style="width: 700px; padding: 1em 1em 1em 1em"|
<font face="trebuchet ms" size=4 style="color:#000000"> Cai, Rongjun 蔡荣俊</font><br>
<div style="text-align: left;>
Second-year Postgraduate Student<br>
<font face="trebuchet ms" size=4 style="color:#000000"> Cai, Rongjun 蔡荣俊</font><br>
<br>
Fourth-year Postgraduate Student<br>
2012.09-present:  School of Medicine, Tsinghua University, PhD;<br>
<br>
2008.09-2012.07: College of Animal Sciences & Technology, Huazhong Agricultural University, Bachelor;<br>
2012.09-present:  School of Medicine, Tsinghua University, PhD;<br>
<br>
2008.09-2012.07: College of Animal Sciences & Technology, Huazhong Agricultural University, Bachelor;<br>
Hobbies: computer techniques<br>
<br>
Email: kim32000{at}hotmail.com (Please replace {at} to @ in the address.)<br>
Hobbies: computer techniques<br>
<br>
Email: kim32000{at}hotmail.com (Please replace {at} to @ in the address.)<br>
In mycobacteria tRNAAsn and tRNAGln are generated by a two-step synthesis, involving physiological misacylation to Glu-tRNAGln and Asp-tRNAAsn intermediates which are amidated to the cognate forms by GatCAB. I am focusing on the role of GatCAB in this indirect pathway to identify its potential link to relative mistranslation rate in mycobacteria. I am also interested in mechanisms to manipulate mycobacteria genetically including generation of SNPs via recombineering.
<br>
;</div>
In mycobacteria tRNAAsn and tRNAGln are generated by a two-step synthesis, involving physiological misacylation to Glu-tRNAGln and Asp-tRNAAsn intermediates which are amidated to the cognate forms by GatCAB. I am focusing on the role of GatCAB in this indirect pathway to identify its potential link to relative mistranslation rate in mycobacteria. I am also interested in mechanisms to manipulate mycobacteria genetically including generation of SNPs via recombineering.
|}
</div>
<br>
|}<br>
</div>


<div style="width:1000px" >
{| cellspacing="0"
{| cellspacing="0"
|- valign="top"
|- valign="top"
|width="100px"|
|width="20%"|
[[Image:THUMTB-M-Graduates.png|100px]]
<div style="text-align: left;>
|width="200px"|
[[Image:THUMTB-LJ.jpg|200px]]
[[Image:THUMTB-LJ.jpg|200px]]
</div>
|style="width: 700px; padding: 1em 1em 1em 1em"|
|width="70%"|
<div style="text-align: left;>
<div style="text-align: left;>
<font face="trebuchet ms" size=4 style="color:#000000"> Long, Jing 龙晶</font><br>
<font face="trebuchet ms" size=4 style="color:#000000"> Long, Jing 龙晶</font><br>
Fourth-year Postgraduate Student<br>
Second-year Postgraduate Student<br>
<br>
<br>
2012.09-present: School of Medicine, Tsinghua University, PhD;<br>
2012.09-present: School of Medicine, Tsinghua University, PhD;<br>
<br>
<br>
Hobbies: photography, food<br>  
Hobbies: photography, food<br>  
<br>
<br>
My projects are based on the hypothesis that mistranslation may contribute to mycobacterial adaption to the intracellular environment. One of my projects is to verify the hypothesis by measuring the mycobacterial mistranslation rate before or after infection; the other one is to understand the interactions between the host and mycobacteria during the process of infection.
My projects are based on the hypothesis that mistranslation may contribute to mycobacterial adaption to the intracellular environment. One of my projects is to verify the hypothesis by measuring the mycobacterial mistranslation rate before or after infection; the other one is to understand the interactions between the host and mycobacteria during the process of infection.
</div>
;</div>
|}<br>
|}
<br>
</div>


<div style="width:1000px" >
{| cellspacing="0"
{| cellspacing="0"
|- valign="top"
|- valign="top"
|width="100px"|
[[Image:THUMTB-M-Graduates.png|100px]]
|width="200px"|
[[Image:THUMTB-LH2.jpg|200px]]
|style="width: 700px; padding: 1em 1em 1em 1em"|
<div style="clear: right; text-align: left; float: left;>
<font face="trebuchet ms" size=4 style="color:#000000"> Li, Hao 李浩</font><br>
Third-year Postgraduate Student (PTN Programme)<br>
<br>
2013.09-present: College of Life Science, Tsinghua University, PhD;<br>
2011.07-2013.09: School of medicine, Tsinghua University, Research assistant;<br>
2008.09-2011.07: Academy of Military Medical Sciences, Master degree;<br>
2004.08-2008.8: Henan Agricultural University, Bachelor degree;<br>
<br>
Hobbies: basketball, hiking, movies<br>
E-mail address: leehao{at}biomed.tsinghua.edu.cn (Please replace {at} to @ in the address.)<br>
<br>
The main Research fields:<br>
1)The interaction of Mycobacteria tuberculosis with the host.<br>
About one third of the population in the world is infected with Mtb and remain asymptomatic. Of the latent population, about 5% will develop active tuberculosis in their lifetime. We want to know that why some individuals are protected from infection while others not. <br>
2)The mechanisms of drug resistance and tolerance in Mycobacteria.  <br>
The MDX/XDR has become a big problem in the world especially in China. Also the Mycobacteria become drug tolerance via natural selection. These may be big barriers to shortening TB treatment. We want to find the mechanisms behind these problems.<br>
</div>
|}<br>


|width="20%"|
{| cellspacing="0"
<div style="clear: right; text-align: left; float: left;>
|- valign="top"
[[Image:THUMTB-LH.jpg|200px]]
|width="100px"|
</div>
[[Image:THUMTB-M-Graduates.png|100px]]
|width="200px"|
[[Image:THUMTB-CYN.JPG|200px]]
|style="width: 700px; padding: 1em 1em 1em 1em"|
<div style="text-align: left;>
<font face="trebuchet ms" size=4 style="color:#000000"> Chen, Yanan 陈亚男</font><br>
Third-year Postgraduate Student (PTN Programme)<br>
<br>
2013.09-present: College of Life Science, Tsinghua University, PhD;<br>
2009.09-2013.07: College of Life Science, Nanjing Agricultural University, Bachelor;<br>
<br>
Hobbies: Hip-Hop, novels <br>
Email: chenyanan90618{at}163.com (Please replace {at} to @ in the address.)<br>
<br>
Stop codons normally represent the termination signal during translation, but sometimes translation can continue through a stop codon, a mechanism known as stop codon readthrough. Previous studies have shown that hundreds of Drosophila genes undergo stop codon readthrough. We therefore expect to determine the precise molecular mechanism for high level stop codon readthrough in Drosophila melanogaster.</div>
|}<br>


|width="70%"|
{| cellspacing="0"
<div style="clear: right; text-align: left; float: left;>
|- valign="top"
<font face="trebuchet ms" size=4 style="color:#000000"> Li, Hao 李浩</font><br>
|width="100px"|
First-year Postgraduate Student (PTN Programme)<br>
[[Image:THUMTB-M-Graduates.png|100px]]
<br>
|width="200px"|
2013.09-present: College of Life Science, Tsinghua University, PhD;<br>
[[Image:THUMTB-ZYW.JPG|200px]]
2011.07-2013.09: School of medicine, Tsinghua University, Research assistant;<br>
|style="width: 700px; padding: 1em 1em 1em 1em"|
2008.09-2011.07: Academy of Military Medical Sciences, Graduate student;<br>
<div style="text-align: left;>
2004.08-2008.8: Henan Agricultural University, Bachelor degree;<br>
<font face="trebuchet ms" size=4 style="color:#000000"> Zhang,Yiwei 张一薇</font><br>
<br>
Third-year Postgraduate Student <br>
Hobbies: basketball, hiking, movies<br>
<br>
E-mail address: leehao{at}biomed.tsinghua.edu.cn (Please replace {at} to @ in the address.)<br>
2013.09-present: College of Medicine, Tsinghua University, PhD;<br>
<br>
2009.09-2013.07: College of Life Science, Nanjing Agricultural University, Bachelor;<br>
The Main research field: The interaction of Mycobacterial with the host.<br>
<br>
Projects:<br>
Hobbies: Violin, travelling<br>
1: Research on the protein Trehalose-6-phosphate Phosphatase (OtsB2) from Mycobacterium tuberculosis.<br>
Email: zhang-yw13{at}mails.tsinghua.edu.cn (Please replace {at} to @ in the address.)<br>
2: Research on antigen presentation during mycobacterial infection.<br>
<br>
</div>
The previous work of the lab indicates that mistranslation may help mycobacteria survive in some antibiotic environments such as rifampicin. This finding leads us to further think the mechanism and effects of mistranslation in eukaryote. So, I choose yeast as my research material, trying to find the genetic elements controlling translation fidelity and find out what effects mistranslation may have on eukaryote.
|}
</div>
<br>
|}<br>
</div>


<div style="width:1000px" >
{| cellspacing="0"
{| cellspacing="0"
|- valign="top"
|- valign="top"
|width="100px"|
[[Image:THUMTB-M-Graduates.png|100px]]
|width="200px"|
[[Image:THUMTB-CYX.jpg|200px]]
|style="width: 700px; padding: 1em 1em 1em 1em"|
<div style="text-align: left;>
<font face="trebuchet ms" size=4 style="color:#000000"> Chen,Yuxiang 陈宇翔</font><br>
Third-year Postgraduate Student <br>
<br>
2013.09-present: School of Life Science, Tsinghua University, PhD;<br>
2009.09-2013.06: School of Life Science, Sichuan University, Bachelor;<br>
<br>
Hobbies: Music, language, Computer games<br>
Email: chenyx13{at}mails.tsinghua.edu.cn (Please replace {at} to @ in the address.)<br>
<br>
1. Mycobacterial leaderless mRNA translation regulation;<br>
2. Ribosome heterogeneity;<br>
3. Mechanism of increasing translation fidelity in mycobacteria
</div>
|}<br>


|width="20%"|
{| cellspacing="0"
<div style="text-align: left;>
|- valign="top"
[[Image:THUMTB-CYN.JPG|200px]]
|width="100px"|
</div>
[[Image:THUMTB-M-Graduates.png|100px]]
|width="200px"|
[[Image:THUMTB-WJZ.JPG|200px]]
|style="width: 700px; padding: 1em 1em 1em 1em"|
<div style="text-align: left;>
<font face="trebuchet ms" size=4 style="color:#000000"> Wang, Jiazi 王嘉梓</font><br>
Second-year Postgraduate Student (CLS Programme) <br>
<br>
2014.09-present: School of Life Science, Tsinghua University, PhD;<br>
2010.09-2014.06: School of Life Science, Xiamen University, Bachelor;<br>
<br>
Hobbies: food film travel shopping<br>
Email: wangjz14{at}mails.tsinghua.edu.cn (Please replace {at} to @ in the address.)<br>
<br>
Transfer RNA isodecoder genes show a large diversity in eukaryotes. But most of their functions are still unknown. I’m interested in how SNPs in human tRNAs may alter their canonical (translation) and non-canonical functions.
</div>
|}<br>


|width="70%"|
<div style="text-align: left;>
<font face="trebuchet ms" size=4 style="color:#000000"> Chen, Yanan 陈亚男</font><br>
First-year Postgraduate Student (PTN Programme)<br>
<br>
2013.09-present: College of Life Science, Tsinghua University, PhD;<br>
2009.09-2013.07: Nanjing Agricultural Universit, Bachelor;<br>
<br>
Hobbies: Korean language, reading novels<br>
Email: chenyanan90618{at}163.com (Please replace {at} to @ in the address.)<br>
<br>
I am investigating the role of EF-Tu discrimination in mycobacterial mistranslation, which will examine one potential mechanism for mycobacterial mistranslation. The residing dogma states that misacylated tRNAs cannot take part in protein translation due to discrimination by EF-Tu, but this has not been investigated in vivo. <br>
We know that fidelity in translation is associated with two key events: synthesis of correctly charged aminoacyl transfer RNAs (aa-tRNAs) by aminoacyl tRNA synthetases (aaRSs) and accurate selection of aa-tRNAs by the ribosome.  However, the precise molecular mechanism of mycobacterial mistranslation is poorly understood.
Specifically, it is not known if mistranslation results from errors of ribosomal decoding or misacylation of amino-acylated tRNAs. This is particularly relevant since mycobacteria physiologically misacylate glutamine and asparagine tRNAs before modifying them to the correct form by the action of the enzyme GatCAB.
</div>
|}
<br>
</div>
<br>
<font face="trebuchet ms" size=5 style="color:#930000">Research Staff</font><br>
<div style="color: #000000; background-color: #FFFFFF; width: 1000px;">
<div style="color: #000000; background-color: #FFFFFF; width: 1000px;">
----
----
</div>
</div><br>
<br>


<div style="width:1000px" >
{| cellspacing="0"
{| cellspacing="0"
|- valign="top"
|- valign="top"
|width="100px"|
[[Image:THUMTB-M-Staff.png|100px]]
|width="200px"|
[[Image:THUMTB-DL.jpg|200px]]
|style="width: 700px; padding: 1em 1em 1em 1em"|
<div style="clear: right; text-align: left; float: left;>
<font face="trebuchet ms" size=4 style="color:#000000"> Duan,Lei 段蕾</font><br>
Assistant / Lab manger<br>
<br>
2013.08-present: School of medicine,Tsinghua University, Research assistant;<br>
2010.09-2010.07: Shanxi medical University, Master degree;<br>
2005.09-2010.07: Lanzhou University, Bachelor degree;<br>
<br>
Hobbies: reading, cooking, music<br>
Email: duanlei87{at}126.com (Please replace {at} to @ in the address.)<br>
<br>
As lab manager, I ensure the smooth and efficient running of the lab. I also act as Babak's assistant and administrative aid.</div>
|}<br>


|width="70%"|
{| cellspacing="0"
<div style="clear: right; text-align: left; float: left;>
|- valign="top"
<font face="trebuchet ms" size=4 style="color:#000000"> Duan,Lei 段蕾</font><br>
|width="100px"|
Assistant / Lab manger<br>
[[Image:THUMTB-M-Staff.png|100px]]
<br>
|width="200px"|
2013.08-present: School of medicine,Tsinghua University,Research assistant;<br>
[[Image:THUMTB-PMM2.jpg|200px]]
2010.09-2010.07: Shanxi medical University, Master degree;<br>
|style="width: 700px; padding: 1em 1em 1em 1em"|
2005.09-2010.07: Lanzhou University,Bachelor degree;<br>
<div style="clear: right; text-align: left; float: left;>
<br>
<font face="trebuchet ms" size=4 style="color:#000000"> Pan, Miaomiao 潘苗苗</font><br>
Hobbies: reading, cooking, music<br>
Research Assistant<br>
Email: duanlei87{at}126.com (Please replace {at} to @ in the address.)<br>
<br>
<br>
2012.07-present: School of medicine, Tsinghua University, Research assistant;<br>
As an assistant,My work is to help Professor Babak Javid to deal with some paperworks between English and Chinese and to make sure he doesn't get into too much trouble in every possible aspect. As a lab manager, I am responsible for making our lab run in an orderly and efficient manner.</div>
2009.09-2012.07: Nankai University, Master degree;<br>
|width="20%"|
2005.09-2009.07: Shaanxi University of Technology, Bachelor degree.<br>
<div style="clear: right; text-align: left; float: left;>
<br>
[[Image:THUMTB-DL.jpg|200px]]
Hobbies: reading, watching movies, climbing and sleeping<br>
</div>
E-mail address: panmm99{at}gmail.com (Please replace {at} to @ in the address.)<br>
|}
<br>
<br>
I am interested in the hypothesis that a high phenotypic drug resistance in mycobacteria species is caused by high adaptive mistranslation. I am currently developing a gain of function reporter to measure the mistranslation rate using a M. smegmatis model. I will use this reporter to screen for molecules that alter mycobacterial translational fidelity. </div>
</div>
|}<br>


<div style="width:1000px" >
{| cellspacing="0"
{| cellspacing="0"
|- valign="top"
|- valign="center"
|width="70%"|
|style="width: 1000px; text-align: center"|
<div style="clear: right; text-align: left; float: left;>
<font size="2" style="color:#000079">LAST UPDATED: September 2015</font><br>
<font face="trebuchet ms" size=4 style="color:#000000"> Wen Kawaji 雯雯</font><br>
Research Assistant<br>
<br>
<br>
2013-present: School of medicine, Tsinghua University, Research assistant;<br>
2011-2013: Johns Hopkins University School of Public Health, Master of Science;<br>
2006-2011: Johns Hopkins University, Bachelor degree;<br>
<br>
Hobbies: Food, books, films, and travel<br>
E-mail address: wenkawaji{at}gmail.com (Please replace {at} to @ in the address.)<br>
<br>
The Main research field: Small molecule screening.<br>
<br>
Mistranslation is important and necessary for mTB phenotypic resistance. Through small molecule screening, we are looking for potential drugs that would play a role in translation fidelity.
</div>
|width="20%"|
<div style="clear: right; text-align: left; float: left;>
[[Image:THUMTB-KAWAJI.jpg|200px]]
</div>
|}
|}
<br>
 
<div style= "width: 1000px">
----
</div>
</div>


<div style="width:1000px" >
{| cellspacing="0"
{| cellspacing="0"
|- valign="top"
|- valign="center"


|width="70%"|
|style="width: 100px; height: 100px;"|
<div style="clear: right; text-align: left; float: left;>
[[Image:THUMTB-hotlinks.png|100px]]
<font face="trebuchet ms" size=4 style="color:#000000"> Pan, Miaomiao 潘苗苗</font><br>
|style="width: 20px; height: 100px;"|
Research Assistant<br>
<br>
2012.07-present: School of medicine, Tsinghua University, Research assistant;<br>
2009.09-2012.07: Nankai University, Master degree;<br>
2005.09-2009.07: Shaanxi University of Technology, Bachelor degree.<br>
<br>
Hobbies: reading, watching movies, climbing and sleeping<br>
E-mail address: panmm99{at}gmail.com (Please replace {at} to @ in the address.)<br>
<br>
I am interested in the hypothesis that a high phenotypic drug resistance in mycobacteria species is caused by high adaptive mistranslation. I am currently developing a gain of function reporter to measure the mistranslation rate using a M. smegmatis model. I will use this reporter assay to screen drugs in order to find hits which can decrease mycobacteria mistranslation. My ultimate goal is to decrease the phenotypic drug resistance of Mycobacteria tuberculosis. My hobbies are.</div>
|width="20%"|
<div style="clear: right; text-align: left; float: left;>
[[Image:THUMTB-PMM.jpg|200px]]
</div>
|}
<br>
</div>


<br>
|style="width: 100px; height: 100px;"|
<font face="trebuchet ms" size=5 style="color:#930000">Undergraduate Students</font><br>
{{Click || image=THUMTB-news.png | link=Javidlab:news | width=100px | height=100px }}
<div style="color: #000000; background-color: #FFFFFF; width: 1000px;">
|style="width: 100px; height: 100px; padding: 0em 0em 0em .5em"|
----
''Exciting things happen here''
</div><br>
|style="width: 20px; height: 100px;"|


<div style="width:1000px" >
|style="width: 100px; height: 100px;"|
{| cellspacing="0"
{{Click || image=THUMTB-research.png | link=Javidlab:research | width=100px | height=100px }}
|- valign="top"
|style="width: 100px; height: 100px; padding: 0em 0em 0em .5em"|
|width="20%"|
''I love my research in Javid Lab''
<div style="text-align: left;>
|style="width: 20px; height: 100px;"|
[[Image:THUMTB-LTQ.JPG|200px]]
</div>
|width="70%"|
<div style="text-align: left;>
<font face="trebuchet ms" size=4 style="color:#000000"> Leng, Tianqi 冷天祺</font><br>
Junior Undergraduate Student (Peking University)<br>
<br>
Hobbies: Marvel superhero movies, swimming, table tennis and badminton.<br>
Email: lengtq{at}gmail.com (Please replace {at} to @ in the address.)<br>
<br>
My project investigates the repertoire and rate of mycobacterial mistranslation in the model organism Mycobacterium smegmatis.  I will use gain of function luminescence reporters to accurately identify the rate of many different types of translational error.
</div>
|}
<br>
</div>


<div style="width:1000px" >
|style="width: 100px; height: 100px;"|
{| cellspacing="0"
{{Click || image=THUMTB-members.png | link=Javidlab:labmembers | width=100px | height=100px }}
|- valign="top"
|style="width: 100px; height: 100px; padding: 0em 0em 0em .5em"|
''Meet our lovely members''
|style="width: 20px; height: 100px;"|


|width="20%"|
|style="width: 100px; height: 100px;"|
<div style="text-align: left;>
{{Click || image=THUMTB-fun.png | link=Javidlab:funstuff | width=100px | height=100px }}
[[Image:THUMTB-HQ.JPG|200px]]
|style="width: 100px; height: 100px; padding: 0em 0em 0em .5em"|
</div>
''Happy Hours''


|width="70%"|
<div style="text-align: left;>
<font face="trebuchet ms" size=4 style="color:#000000"> He, Qiao 贺桥</font><br>
Junior Undergraduate Student (Peking University)<br>
<br>
Hobbies: Surfing Internet, playing basketball, reading<br>
Email: rodefo{at}gmail.com (Please replace {at} to @ in the address.)<br>
<br>
I am interested in using fluorescent reporters to measure mycobacterial mistranslation rates.
</div>
|}
|}
<br>
</div>


</div>
</font>
|}
<div style= "width: 1000px">
<div style= "width: 1000px">
----
----
</div>
{| cellspacing="0"
{| cellspacing="0"
|- valign="center"
|- valign="center"


|width="49%" style="background-color: #F0F0F0"|
|width=700px|
<div style="text-align: right; float: none; width: 490px; height: 60px"; valign= "center">
|width=100px|
[[Image: THU-LOGO.png|60px|right]]
[[image:THUMTB-spin.gif|100px]]
</div>
|width=200px|
[[image:THUMTB-slogen.png|200px]]


|width="1%" style="background-color: #F0F0F0"|
|}
<div style="text-align: right; float: none; width: 10px; height: 60px"; valign= "center">
</div>


|width="50%" style="background-color: #F0F0F0"|
<div style="text-align: left; float: none; width: 500px; height: 60px">
<font face="Georgia">
Room 4-302 Biotech Building<br>
School of Medicine<br>
Tsinghua University
</font>
</font>
</div>
|}
</div>
</div>
</center>
</center>

Latest revision as of 08:52, 13 September 2016

Room 4-304 Biotech Building
School of Medicine, Tsinghua University

HOME

NEWS

Research

Publication

Members

Alumni

Fun

Contact


Babak Javid

Babak Javid is a physician scientist with an interest in tuberculosis, infectious diseases and protein translational fidelity. He did his medical training in the UK, his PhD on antigen processing and presentation with Paul Lehner at Cambridge, and post-doctoral training on mycobacterial genetics with Eric Rubin at Harvard. He joined Tsinghua School of Medicine in October 2011.

Email: bjavid{at}gmail.com (Please replace {at} to @ in the address.)

Melody Toosky

Post-doc, funded by the Gates Foundation, Harvard Chan School of Public Health, USA, 2014- present;
Post-doc, Tsinghua University, 2012- 2014;
Ph.D., Microbiology and Immunology, University of North Dakota 2012;
B.S., Biology, University of California, Irvine 2004;

Hobbies: Chinese language, culture, music and food
Email: mtoosky{at}gmail.com (Please replace {at} to @ in the address.)

Mycobacterial infections are characterized by the need of the host to contain the invading pathogen as well as by the need of the pathogen to escape the host cell in order to infect other cells. An important phase during this interaction pertains to host cell death decision pathway. My project involves looking at this pathway using proteomic tools to get some clues about how mycobacteria can influence the manner in which host cells die.

Swarnava Chaudhuri

Post-doc, Tsinghua University, 2014-present;
Post-doc, Meharry Medical College, 2013-2014;
Post-doc, University of California, Santa Barbara, 2011-2012;
Ph.D, Microbiology & Immunology, University of Illinois at Chicago, 2011;
M.Sc, Biochemistry, University of Calcutta, 2005;
B.Sc, Microbiology, University of Calcutta, 2003;

Hobbies: Travelling, photography, reading
Email: swarnavachau{at}yahoo.com (Please replace {at} to @ in the address.)

The prolonged antibiotic regime during treatment of tuberculosis is a serious healthcare burden. The long treatment period for tuberculosis results from rifampicin tolerance in Mycobacteria. Reduced translational fidelity, which results in the formation of mistranslated protein variants, is a key mechanism behind rifampicin tolerance in mycobacteria. My project is to identify drugs that increase the translational fidelity in mycobacteria, and thereby make the bacterium more susceptible to rifampicin。The other part of my project is to identify the mechanism by which these drugs increase translational fidelity in mycobacteria.

Zhu, Junhao 朱军豪
Fifth-year Postgraduate Student (PTN Programme)

2011.09-present: College of Life Science, Peking University, PhD;
2007.09-2011.07: College of Life Science, Peking University ,Bachelor;

Hobbies: basketball, painting and cooking
E-mail address: newforlofe{at}gmail.com (Please replace {at} to @ in the address.)

In a homogeneous bacterial population (identical in genomic information), the phenotypes of individual cells may vary significantly due to gene expression, protein synthesis and other processes. One reason for this variation may be the rate of errors generated during protein synthesis (mistranslation), which we hypothesise may benefit cell survival when they are challenged by stress or antibiotics. I am designing novel reporters to measure mistranslation at the single cell level. I hope to find what's controlling the heterogeneity of mistranslation in a clonal population and a potential clues for novel drug development.


Su, Hongwei 苏宏伟
Fourth-year Postgraduate Student (PTN Programme)

2012.09-present: College of Life Science, Tsinghua University, PhD;
2007.09-2012.07: College of Animal Husbandry and Veterinary, Jilin university, Bachelor;

Hobbies: basketball, and other sports, watching movies
Email: suhongwei0108{at}gmail.com (Please replace {at} to @ in the address.)

Based on previous work of the lab, mycobacteria could tolerate high mistranslation rates and this phenotype could help them to adapt to different kinds of environment including some antibiotic such as rifampicin. So there may be some specific elements which control translational fidelity. My project is to find the genetic elements controlling mycobacterial translation fidelity using forward genetic screens.


Cai, Rongjun 蔡荣俊
Fourth-year Postgraduate Student

2012.09-present: School of Medicine, Tsinghua University, PhD;
2008.09-2012.07: College of Animal Sciences & Technology, Huazhong Agricultural University, Bachelor;

Hobbies: computer techniques
Email: kim32000{at}hotmail.com (Please replace {at} to @ in the address.)

In mycobacteria tRNAAsn and tRNAGln are generated by a two-step synthesis, involving physiological misacylation to Glu-tRNAGln and Asp-tRNAAsn intermediates which are amidated to the cognate forms by GatCAB. I am focusing on the role of GatCAB in this indirect pathway to identify its potential link to relative mistranslation rate in mycobacteria. I am also interested in mechanisms to manipulate mycobacteria genetically including generation of SNPs via recombineering.


Long, Jing 龙晶
Fourth-year Postgraduate Student

2012.09-present: School of Medicine, Tsinghua University, PhD;

Hobbies: photography, food

My projects are based on the hypothesis that mistranslation may contribute to mycobacterial adaption to the intracellular environment. One of my projects is to verify the hypothesis by measuring the mycobacterial mistranslation rate before or after infection; the other one is to understand the interactions between the host and mycobacteria during the process of infection.


Li, Hao 李浩
Third-year Postgraduate Student (PTN Programme)

2013.09-present: College of Life Science, Tsinghua University, PhD;
2011.07-2013.09: School of medicine, Tsinghua University, Research assistant;
2008.09-2011.07: Academy of Military Medical Sciences, Master degree;
2004.08-2008.8: Henan Agricultural University, Bachelor degree;

Hobbies: basketball, hiking, movies
E-mail address: leehao{at}biomed.tsinghua.edu.cn (Please replace {at} to @ in the address.)

The main Research fields:
1)The interaction of Mycobacteria tuberculosis with the host.
About one third of the population in the world is infected with Mtb and remain asymptomatic. Of the latent population, about 5% will develop active tuberculosis in their lifetime. We want to know that why some individuals are protected from infection while others not.
2)The mechanisms of drug resistance and tolerance in Mycobacteria.
The MDX/XDR has become a big problem in the world especially in China. Also the Mycobacteria become drug tolerance via natural selection. These may be big barriers to shortening TB treatment. We want to find the mechanisms behind these problems.

Chen, Yanan 陈亚男
Third-year Postgraduate Student (PTN Programme)

2013.09-present: College of Life Science, Tsinghua University, PhD;
2009.09-2013.07: College of Life Science, Nanjing Agricultural University, Bachelor;

Hobbies: Hip-Hop, novels
Email: chenyanan90618{at}163.com (Please replace {at} to @ in the address.)

Stop codons normally represent the termination signal during translation, but sometimes translation can continue through a stop codon, a mechanism known as stop codon readthrough. Previous studies have shown that hundreds of Drosophila genes undergo stop codon readthrough. We therefore expect to determine the precise molecular mechanism for high level stop codon readthrough in Drosophila melanogaster.

Zhang,Yiwei 张一薇
Third-year Postgraduate Student

2013.09-present: College of Medicine, Tsinghua University, PhD;
2009.09-2013.07: College of Life Science, Nanjing Agricultural University, Bachelor;

Hobbies: Violin, travelling
Email: zhang-yw13{at}mails.tsinghua.edu.cn (Please replace {at} to @ in the address.)

The previous work of the lab indicates that mistranslation may help mycobacteria survive in some antibiotic environments such as rifampicin. This finding leads us to further think the mechanism and effects of mistranslation in eukaryote. So, I choose yeast as my research material, trying to find the genetic elements controlling translation fidelity and find out what effects mistranslation may have on eukaryote.


Chen,Yuxiang 陈宇翔
Third-year Postgraduate Student

2013.09-present: School of Life Science, Tsinghua University, PhD;
2009.09-2013.06: School of Life Science, Sichuan University, Bachelor;

Hobbies: Music, language, Computer games
Email: chenyx13{at}mails.tsinghua.edu.cn (Please replace {at} to @ in the address.)

1. Mycobacterial leaderless mRNA translation regulation;
2. Ribosome heterogeneity;
3. Mechanism of increasing translation fidelity in mycobacteria


Wang, Jiazi 王嘉梓
Second-year Postgraduate Student (CLS Programme)

2014.09-present: School of Life Science, Tsinghua University, PhD;
2010.09-2014.06: School of Life Science, Xiamen University, Bachelor;

Hobbies: food film travel shopping
Email: wangjz14{at}mails.tsinghua.edu.cn (Please replace {at} to @ in the address.)

Transfer RNA isodecoder genes show a large diversity in eukaryotes. But most of their functions are still unknown. I’m interested in how SNPs in human tRNAs may alter their canonical (translation) and non-canonical functions.



Duan,Lei 段蕾
Assistant / Lab manger

2013.08-present: School of medicine,Tsinghua University, Research assistant;
2010.09-2010.07: Shanxi medical University, Master degree;
2005.09-2010.07: Lanzhou University, Bachelor degree;

Hobbies: reading, cooking, music
Email: duanlei87{at}126.com (Please replace {at} to @ in the address.)

As lab manager, I ensure the smooth and efficient running of the lab. I also act as Babak's assistant and administrative aid.

Pan, Miaomiao 潘苗苗
Research Assistant

2012.07-present: School of medicine, Tsinghua University, Research assistant;
2009.09-2012.07: Nankai University, Master degree;
2005.09-2009.07: Shaanxi University of Technology, Bachelor degree.

Hobbies: reading, watching movies, climbing and sleeping
E-mail address: panmm99{at}gmail.com (Please replace {at} to @ in the address.)

I am interested in the hypothesis that a high phenotypic drug resistance in mycobacteria species is caused by high adaptive mistranslation. I am currently developing a gain of function reporter to measure the mistranslation rate using a M. smegmatis model. I will use this reporter to screen for molecules that alter mycobacterial translational fidelity.

LAST UPDATED: September 2015

Exciting things happen here

I love my research in Javid Lab

Meet our lovely members

Happy Hours

Retrieved from "https://openwetware.org/mediawiki/index.php?title=Javidlab:labmembers&oldid=951853"