Javidlab:labmembers: Difference between revisions
Babak Javid (talk | contribs) No edit summary |
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Email: lengtq{at}gmail.com<br> | Email: lengtq{at}gmail.com<br> | ||
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My project investigates the repertoire and rate of mycobacterial mistranslation in the model organism Mycobacterium smegmatis. I will use gain of function luminescence reporters to accurately identify the rate of many different types of translational error.</div> | My project investigates the repertoire and rate of mycobacterial mistranslation in the model organism Mycobacterium smegmatis. I will use gain of function luminescence reporters to accurately identify the rate of many different types of translational error. | ||
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I am investigating the role of EF-Tu discrimination in mycobacterial mistranslation, which will examine one potential mechanism for mycobacterial mistranslation. The residing dogma states that misacylated tRNAs cannot take part in protein translation due to discrimination by EF-Tu, but this has not been investigated in vivo. <br> | I am investigating the role of EF-Tu discrimination in mycobacterial mistranslation, which will examine one potential mechanism for mycobacterial mistranslation. The residing dogma states that misacylated tRNAs cannot take part in protein translation due to discrimination by EF-Tu, but this has not been investigated in vivo. <br> | ||
We know that fidelity in translation is associated with two key events: synthesis of correctly charged aminoacyl transfer RNAs (aa-tRNAs) by aminoacyl tRNA synthetases (aaRSs) and accurate selection of aa-tRNAs by the ribosome. However, the precise molecular mechanism of mycobacterial mistranslation is poorly understood. | We know that fidelity in translation is associated with two key events: synthesis of correctly charged aminoacyl transfer RNAs (aa-tRNAs) by aminoacyl tRNA synthetases (aaRSs) and accurate selection of aa-tRNAs by the ribosome. However, the precise molecular mechanism of mycobacterial mistranslation is poorly understood. | ||
Specifically, it is not known if mistranslation results from errors of ribosomal decoding or misacylation of amino-acylated tRNAs. This is particularly relevant since mycobacteria physiologically misacylate glutamine and asparagine tRNAs before modifying them to the correct form by the action of the enzyme GatCAB.</div> | Specifically, it is not known if mistranslation results from errors of ribosomal decoding or misacylation of amino-acylated tRNAs. This is particularly relevant since mycobacteria physiologically misacylate glutamine and asparagine tRNAs before modifying them to the correct form by the action of the enzyme GatCAB. | ||
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Revision as of 20:14, 22 May 2013
PI
Postdocs
Melody Toosky |
Graduate Students
Zhu, Junhao 朱军豪 |
Su, Hongwei 苏宏伟 |
Cai, Rongjun 蔡荣俊 |
Long, Jing 龙晶 |
Research Staff
Xue, Jiaying 薛佳莹 |
Li, Hao 李浩 |
Pan, Miaomiao 潘苗苗 |
Undergraduate Students
Du, Yuxian 杜禹贤 |
Leng, Tianqi 冷天祺 |
Chen, Yanan 陈亚男 |