Javidlab:labmembers: Difference between revisions
Babak Javid (talk | contribs) No edit summary |
Babak Javid (talk | contribs) No edit summary |
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<font face="trebuchet ms" size=4 style="color:#000000">Email: </font>bjavid{at}gmail.com<br> | <font face="trebuchet ms" size=4 style="color:#000000">Email: </font>bjavid{at}gmail.com (Please replace {at} to @ in the address.)<br> | ||
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<font face="trebuchet ms" size=4 style="color:#000000">Education and Training:</font><br><br> | <font face="trebuchet ms" size=4 style="color:#000000">Education and Training:</font><br><br> | ||
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B.S., Biology, University of California, Irvine 2004;<br><br> | B.S., Biology, University of California, Irvine 2004;<br><br> | ||
Hobbies: Chinese language, culture, music and food<br> | Hobbies: Chinese language, culture, music and food<br> | ||
Email: mtoosky{at}gmail.com<br> | Email: mtoosky{at}gmail.com (Please replace {at} to @ in the address.)<br> | ||
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Mycobacterial infections are characterized by the need of the host to contain the invading pathogen as well as by the need of the pathogen to escape the host cell in order to infect other cells. An important phase during this interaction pertains to host cell death decision pathway. My project involves looking at this pathway using proteomic tools to get some clues about how mycobacteria can influence the manner in which host cells die.;</div> | Mycobacterial infections are characterized by the need of the host to contain the invading pathogen as well as by the need of the pathogen to escape the host cell in order to infect other cells. An important phase during this interaction pertains to host cell death decision pathway. My project involves looking at this pathway using proteomic tools to get some clues about how mycobacteria can influence the manner in which host cells die.;</div> | ||
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Hobbies: basketball, painting and cooking<br> | Hobbies: basketball, painting and cooking<br> | ||
E-mail address: newforlofe{at}gmail.com<br> | E-mail address: newforlofe{at}gmail.com (Please replace {at} to @ in the address.)<br> | ||
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In a homogeneous bacterial population (identical in genomic information), the phenotypes of individual cells may vary significantly due to gene expression, protein synthesis and other processes. One reason for this variation may be the rate of errors generated during protein synthesis (mistranslation), which we hypothesise may benefit cell survival when they are challenged by stress or antibiotics. I am designing novel reporters to measure mistranslation at the single cell level. I hope to find what's controlling the heterogeneity of mistranslation in a clonal population and a potential clues for novel drug development. | In a homogeneous bacterial population (identical in genomic information), the phenotypes of individual cells may vary significantly due to gene expression, protein synthesis and other processes. One reason for this variation may be the rate of errors generated during protein synthesis (mistranslation), which we hypothesise may benefit cell survival when they are challenged by stress or antibiotics. I am designing novel reporters to measure mistranslation at the single cell level. I hope to find what's controlling the heterogeneity of mistranslation in a clonal population and a potential clues for novel drug development. | ||
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Hobbies: basketball, and other sports, watching movies<br> | Hobbies: basketball, and other sports, watching movies<br> | ||
Email: suhongwei0108{at}gmail.com<br> | Email: suhongwei0108{at}gmail.com (Please replace {at} to @ in the address.)<br> | ||
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Based on previous work of the lab, mycobacteria could tolerate high mistranslation rates and this phenotype could help them to adapt to different kinds of environment including some antibiotic such as rifampicin. So there may be some specific elements which control translational fidelity. | Based on previous work of the lab, mycobacteria could tolerate high mistranslation rates and this phenotype could help them to adapt to different kinds of environment including some antibiotic such as rifampicin. So there may be some specific elements which control translational fidelity. | ||
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Hobbies: computer techniques<br> | Hobbies: computer techniques<br> | ||
Email: kim32000{at}hotmail.com<br> | Email: kim32000{at}hotmail.com (Please replace {at} to @ in the address.)<br> | ||
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In mycobacteria tRNAAsn and tRNAGln are generated by a two-step synthesis, involving physiological misacylation to Glu-tRNAGln and Asp-tRNAAsn intermediates which are amidated to the cognate forms by GatCAB. I am focusing on the role of GatCAB in this indirect pathway to identify its potential link to relative mistranslation rate in mycobacteria. I am also interested in mechanisms to manipulate mycobacteria genetically including generation of SNPs via recombineering. | In mycobacteria tRNAAsn and tRNAGln are generated by a two-step synthesis, involving physiological misacylation to Glu-tRNAGln and Asp-tRNAAsn intermediates which are amidated to the cognate forms by GatCAB. I am focusing on the role of GatCAB in this indirect pathway to identify its potential link to relative mistranslation rate in mycobacteria. I am also interested in mechanisms to manipulate mycobacteria genetically including generation of SNPs via recombineering. | ||
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Hobbies: climbing, hiking<br> | Hobbies: climbing, hiking<br> | ||
Email: xuejiaying2006{at}hotmail.com<br> | Email: xuejiaying2006{at}hotmail.com (Please replace {at} to @ in the address.)<br> | ||
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My work is to make our lab run in an orderly and efficient manner. This includes procurement and management. I also help Professor Babak Javid as his assistant, for example translation of documents between English and Chinese and generally making sure he doesn’t get into too much trouble.</div> | My work is to make our lab run in an orderly and efficient manner. This includes procurement and management. I also help Professor Babak Javid as his assistant, for example translation of documents between English and Chinese and generally making sure he doesn’t get into too much trouble.</div> | ||
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Hobbies: basketball, hiking, movies<br> | Hobbies: basketball, hiking, movies<br> | ||
E-mail address: leehao{at}biomed.tsinghua.edu.cn<br> | E-mail address: leehao{at}biomed.tsinghua.edu.cn (Please replace {at} to @ in the address.)<br> | ||
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The Main research field: The interaction of Mycobacterial with the host.<br> | The Main research field: The interaction of Mycobacterial with the host.<br> | ||
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Hobbies: reading, watching movies, climbing and sleeping<br> | Hobbies: reading, watching movies, climbing and sleeping<br> | ||
E-mail address: panmm99{at}gmail.com<br> | E-mail address: panmm99{at}gmail.com (Please replace {at} to @ in the address.)<br> | ||
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I am interested in the hypothesis that a high phenotypic drug resistance in mycobacteria species is caused by high adaptive mistranslation. I am currently developing a gain of function reporter to measure the mistranslation rate using a M. smegmatis model. I will use this reporter assay to screen drugs in order to find hits which can decrease mycobacteria mistranslation. My ultimate goal is to decrease the phenotypic drug resistance of Mycobacteria tuberculosis. My hobbies are.</div> | I am interested in the hypothesis that a high phenotypic drug resistance in mycobacteria species is caused by high adaptive mistranslation. I am currently developing a gain of function reporter to measure the mistranslation rate using a M. smegmatis model. I will use this reporter assay to screen drugs in order to find hits which can decrease mycobacteria mistranslation. My ultimate goal is to decrease the phenotypic drug resistance of Mycobacteria tuberculosis. My hobbies are.</div> | ||
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Hobbies: calligraphy, poem recitation performance, singing, and sports.<br> | Hobbies: calligraphy, poem recitation performance, singing, and sports.<br> | ||
Emali: bobthu09{at}gmail.com<br> | Emali: bobthu09{at}gmail.com (Please replace {at} to @ in the address.)<br> | ||
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My project focuses on the dynamics of macrophage surface proteins following mycobacterial infection. Mycobacteria have co-evolved with its host, macrophages, so that they are fully adapted to living inside this effector cell of the innate immune system. Many changes to surface proteins occur following infection but it is unclear whether these changes represent host responses to infection, or mycobacterial adaptations to the host – subverting the host machinery for their own needs. Further experiments will attempt to answer these questions.</div> | My project focuses on the dynamics of macrophage surface proteins following mycobacterial infection. Mycobacteria have co-evolved with its host, macrophages, so that they are fully adapted to living inside this effector cell of the innate immune system. Many changes to surface proteins occur following infection but it is unclear whether these changes represent host responses to infection, or mycobacterial adaptations to the host – subverting the host machinery for their own needs. Further experiments will attempt to answer these questions.</div> | ||
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Hobbies: Marvel superhero movies, swimming, table tennis and badminton.<br> | Hobbies: Marvel superhero movies, swimming, table tennis and badminton.<br> | ||
Email: lengtq{at}gmail.com<br> | Email: lengtq{at}gmail.com (Please replace {at} to @ in the address.)<br> | ||
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My project investigates the repertoire and rate of mycobacterial mistranslation in the model organism Mycobacterium smegmatis. I will use gain of function luminescence reporters to accurately identify the rate of many different types of translational error. | My project investigates the repertoire and rate of mycobacterial mistranslation in the model organism Mycobacterium smegmatis. I will use gain of function luminescence reporters to accurately identify the rate of many different types of translational error. | ||
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Hobbies: Surfing Internet, playing basketball, reading<br> | Hobbies: Surfing Internet, playing basketball, reading<br> | ||
Email: rodefo{at}gmail.com<br> | Email: rodefo{at}gmail.com (Please replace {at} to @ in the address.)<br> | ||
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I am interested in using fluorescent reporters to measure mycobacterial mistranslation rates. | I am interested in using fluorescent reporters to measure mycobacterial mistranslation rates. | ||
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Hobbies: Korean language, reading novels<br> | Hobbies: Korean language, reading novels<br> | ||
Email: chenyanan90618{at}163.com<br> | Email: chenyanan90618{at}163.com (Please replace {at} to @ in the address.)<br> | ||
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I am investigating the role of EF-Tu discrimination in mycobacterial mistranslation, which will examine one potential mechanism for mycobacterial mistranslation. The residing dogma states that misacylated tRNAs cannot take part in protein translation due to discrimination by EF-Tu, but this has not been investigated in vivo. <br> | I am investigating the role of EF-Tu discrimination in mycobacterial mistranslation, which will examine one potential mechanism for mycobacterial mistranslation. The residing dogma states that misacylated tRNAs cannot take part in protein translation due to discrimination by EF-Tu, but this has not been investigated in vivo. <br> |
Revision as of 23:00, 29 May 2013
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Room 4-302 Biotech Building |