Javidlab:research: Difference between revisions
Babak Javid (talk | contribs) No edit summary |
Babak Javid (talk | contribs) No edit summary |
||
Line 1: | Line 1: | ||
<center> | <center> | ||
<div style="background-color: #F0F0F0"> | <div style="background-color: #F0F0F0"> | ||
<font face="Georgia"> | |||
<br> | <br> | ||
<br> | <br> | ||
{| | |||
|- | {| cellspacing="0" | ||
|| | |- valign="center" | ||
< | |style="clear: right; text-align: center; float: none; width: 640px"| | ||
[[Image:THUMTB-LOGO3.png|640px]] | |||
|style="clear: right; text-align: right; float: none; width: 295px"| | |||
'''Room 4-304 Biotech Building'''<br> | |||
'''School of Medicine, Tsinghua University'''<br> | |||
|style="clear: right; text-align: right; float: none; width: 5px"| | |||
|style="clear: right; text-align: left; float: none; width: 60px"| | |||
[[Image:THU-LOGO.png|60px]] | |||
|} | |||
{| cellspacing="0" | {| cellspacing="0" | ||
|- valign="center" | |- valign="center" | ||
|width=" | |style="width: 123px; height: 10px; color: #ffffff; background-color: #000079; text-align: center; padding: 0em 0em 0em 0em"| | ||
< | [[Javidlab | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''HOME''' </font>]] | ||
[[ | |style="width: 2px; height: 10px"| | ||
</ | |||
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000081; text-align: center; padding: 0em 0em 0em 0em"| | |||
[[Javidlab:news | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''NEWS''' </font>]] | |||
|style="width: 2px; height: 10px"| | |||
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000083; text-align: center; padding: 0em 0em 0em 0em"| | |||
[[Javidlab:research | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''Research''' </font>]] | |||
|style="width: 2px; height: 10px"| | |||
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000085; text-align: center; padding: 0em 0em 0em 0em"| | |||
[[Javidlab:publications | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''Publication''' </font>]] | |||
|style="width: 2px; height: 10px"| | |||
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000087; text-align: center; padding: 0em 0em 0em 0em"| | |||
[[Javidlab:labmembers | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''Members''' </font>]] | |||
|style="width: 2px; height: 10px"| | |||
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000089; text-align: center; padding: 0em 0em 0em 0em"| | |||
[[Javidlab:labalumni | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''Alumni''' </font>]] | |||
|style="width: 2px; height: 10px"| | |||
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000091; text-align: center; padding: 0em 0em 0em 0em"| | |||
[[Javidlab:funstuff | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''Fun''' </font>]] | |||
|style="width: 2px; height: 10px"| | |||
|style="width: 123px; height: 10px; color: #ffffff; background-color: #000093; text-align: center; padding: 0em 0em 0em 0em"| | |||
[[Javidlab:contact | <font face="trebuchet ms" size=2 style="color:#ffffff"> '''Contact''' </font>]] | |||
|style="width: 2px; height: 10px"| | |||
|} | |} | ||
<div style="width: 1000px"> | <div style="width: 1000px"> | ||
{| cellspacing="0" | {| cellspacing="0" | ||
Line 130: | Line 155: | ||
<div style= "width: 1000px"> | |||
---- | |||
</div> | |||
{| cellspacing="0" | |||
|- valign="center" | |||
|style="width: 100px; height: 100px;"| | |||
[[Image:THUMTB-hotlinks.png|100px]] | |||
|style="width: 20px; height: 100px;"| | |||
|style="width: 100px; height: 100px;"| | |||
{{Click || image=THUMTB-news.png | link=Javidlab:news | width=100px | height=100px }} | |||
|style="width: 100px; height: 100px; padding: 0em 0em 0em .5em"| | |||
''Exciting things happen here'' | |||
|style="width: 20px; height: 100px;"| | |||
|style="width: 100px; height: 100px;"| | |||
{{Click || image=THUMTB-research.png | link=Javidlab:research | width=100px | height=100px }} | |||
|style="width: 100px; height: 100px; padding: 0em 0em 0em .5em"| | |||
''I love my research in Javid Lab'' | |||
|style="width: 20px; height: 100px;"| | |||
|style="width: 100px; height: 100px;"| | |||
{{Click || image=THUMTB-members.png | link=Javidlab:labmembers | width=100px | height=100px }} | |||
|style="width: 100px; height: 100px; padding: 0em 0em 0em .5em"| | |||
''Meet our lovely members'' | |||
|style="width: 20px; height: 100px;"| | |||
|style="width: 100px; height: 100px;"| | |||
{{Click || image=THUMTB-fun.png | link=Javidlab:funstuff | width=100px | height=100px }} | |||
|style="width: 100px; height: 100px; padding: 0em 0em 0em .5em"| | |||
''Happy Hours'' | |||
|} | |} | ||
<div style= "width: 1000px"> | <div style= "width: 1000px"> | ||
---- | ---- | ||
</div> | |||
{| cellspacing="0" | {| cellspacing="0" | ||
|- valign="center" | |- valign="center" | ||
|width= | |width=700px| | ||
|width=100px| | |||
[[ | [[image:THUMTB-spin.gif|100px]] | ||
|width=200px| | |||
[[image:THUMTB-slogen.png|200px]] | |||
| | |} | ||
</font> | </font> | ||
</div> | </div> | ||
</center> | </center> |
Revision as of 11:21, 9 September 2015
Room 4-304 Biotech Building |
OVERVIEW |
Tuberculosis causes more deaths globally, and in China, than any other single pathogen. Some of the reasons for its success are the ability of the causative organism, Mycobacterium tuberculosis, to lie undetected in the host for decades (clinical latency), the very long treatment times for successful antibiotic treatment (phenotypic resistance) and emerging drug resistance to effective antibiotics. The Javid laboratory is interested in investigating some of the fundamental physiological mycobacterial processes that may contribute to these phenotypes. |
Adaptive |
We have previously shown that the protein translation error rate (mistranslation rate) in mycobacteria is unusually high. Importantly, manipulation of the error rate, both up and down, appears to have profound effects on antibiotic phenotypic resistance. We have shown that mycobacterial strains with high error rates have remarkable phenotypic resistance to the antibiotic rifampicin, and the opposite is true for high fidelity mutants. We are interested in investigating the basic mechanism for these observations, and identifying other potentially adaptive phenotypes that arise from low translational fidelity. |
Mycobacteria |
The majority of people infected with M. tuberculosis – almost a third of the world’s population – do not become ill unless their immune system weakens. This suggests that mycobacteria have evolved to evade host immune responses, much like other chronic infections. We are interested in investigating the mechanisms by which mycobacteria manipulate the host environment to their own ends. We use a variety of approaches – including proteomic profiling of mycobacteria-infected cells, flow cytometry and forward genetics to address these questions. |
Protein |
The lab’s interest in protein translation fidelity arose from our observation regarding ‘adaptive mistranslation’ in mycobacteria (see above). We are extending these findings to other organisms and systems to determine the mechanisms by which organisms may tune translational fidelity. |
GatCAB dependent |
Unlike eukaryotic cytosols, the majority of bacteria and archae utilise a two-step, indirect pathway to make amino-acylated glutamine and/or asparagine tRNA. To ensure fidelity of the genetic code, physiologically misacylated tRNAs (Glu-tRNAGln and Asp-tRNAAsn) are recognised by the heterotrimeric enzyme GatCAB, and through a transamidation reaction, synthesise the cognate amino-acyl tRNA. The lab is interested in determining the biochemistry of this process in mycobacteria and applying that to investigate ‘statistical proteome’ analysis in mycobacterial physiology. |
Exciting things happen here |
I love my research in Javid Lab |
Meet our lovely members |
Happy Hours |