Jewett Lab

Department of Chemical and Biological Engineering 2145 Sheridan Road Northwestern University Evanston, IL 60208-3120 Contact

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Mission Statement Our research aims to engineer biological systems for compelling applications in medicine and biotechnology. We do this to understand how the living world works and to harness biology for societal needs. Specifically, we focus on cell-free systems, which are not constrained by cellular complexity, structural barriers and viability. We aim to develop enabling technologies that push the frontiers of biology by design. We seek to exploit the renewability and evolvability of biology to synthesize abiological polymers that augment biological space with new chemistries. We aim to accelerate the construction of synthetic biomolecular machines making natural and unnatural biopolymers. We integrate fundamental science with technology development. We approach the engineering science of synthetic biology with the goal of creative and cost-effective solutions to today’s technological challenges. Our laboratory fosters an inclusive, motivated, and creative culture which produces both world-class science and synthetic biology experts.

Professor Michael Jewett Graduate Students Andrea Engel Brian Fritz Rue Gan Eric Hodgman Laura Timmerman Eric Tseng Post Doctorates Anne Bunner Rue Gan Undergraduates Ethan Altman Diana Lorenzini

Publications Jewett, M.C., Calhoun, K.A., Voloshin, A., Wuu, J.J., and Swartz, J.R. 2008. An integrated cell-free metabolic platform for protein production and synthetic biology. Molecular Systems Biology. 4:220. Pizarro, F.J. †, Jewett, M.C.†, Nielsen, J., and Agosin, E. 2008. Physiological and transcriptional mapping of evolutionary differences between commercial and laboratory Saccharomyces cerevisiae strains. Appl. Environ. Microbiol.74: 6358-6368. Fazio, A.†, Jewett, M.C.†, Daran-Lapujade, P., Mustacchi, R., Usaite, R., Pronk, J.T., Workman, C.T., and Nielsen, J. 2008. Transcription factor control of growth rate dependent genes in Saccharomyces cerevisiae: a three factor design. BMC Genomics. 9:341. see complete list...

Announcements Ad posting for new postdoc position in nanotechnology and synthetic biology Group meeting, journal clubs, and seminars Welcome new lab members!