Jordan T. Detamore Week 4

Purpose

The purpose of this study was to continue to learn how to use tools from the Biology Workbench and work with HIV sequences. We will use the tools learned in our own projects

Methods & Results

The preloaded sequence feels were uploaded into the nucleic acid tool set of the Biology Workbench
A multiple sequence alignment and distance tree was created from 3 clones from 4 subjects-The subjects, clone, and tree is shown below

Data & Files

Conclusion

Defining Research Project

Question

Is there a genetic difference in HIV-1 in patients who contracted the virus sexually or by intravenous injection?

Hypothesis

We hypothesize that there will not be a genetic difference in HIV-1 in patients who contracted the virus sexually or by intravenous injection

Subjects, Visits, Clones

We will use 25 sequences from the moderate progressor category in Markham et al. This will be the best group to compare to outside sequences because they are the most stable group in terms of visits. For the other half of the sequences, we will search more recent studies for sexually contracted HIV-1 sequences. This will be completed during class on 9/26.