Josh Michener: Difference between revisions
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==Research Experience== | ==Research Experience== | ||
*NRSA Postdoctoral Fellow in the Marx Lab, Harvard | *NRSA Postdoctoral Fellow in the Marx Lab, Harvard Organismic and Evolutionary Biology and Alm Lab, MIT Biological Engineering | ||
*Nordic Research Fellow in the Nielsen Lab, Chalmers Institute of Technology (Gothenburg, Sweden) | *Nordic Research Fellow in the Nielsen Lab, Chalmers Institute of Technology (Gothenburg, Sweden) | ||
*NSF Graduate Research Fellow in the Smolke Lab, Caltech/Stanford Bioengineering | *NSF Graduate Research Fellow in the Smolke Lab, Caltech/Stanford Bioengineering | ||
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==Contact Info== | ==Contact Info== | ||
Josh Michener<br> | Josh Michener<br> | ||
500 Tech Square Room 309<br> | |||
Cambridge, MA, | Cambridge, MA, 02139<br> | ||
[[Image:Michener-email.png]] | [[Image:Michener-email.png]] | ||
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==Publications== | ==Publications== | ||
===Research Articles=== | ===Research Articles=== | ||
*'''Michener JK''', Carmargo-Neves AA, Vuilleumier S, Bringel F, and Marx CJ. | |||
*'''Michener JK''', Vuilleumier S, Bringel F, and Marx CJ. Phylogeny poorly predicts the utility of a challenging horizontally-transferred gene in ''Methylobacterium'' strains. J Bacteriol. June 2014 196:2101-2107. [http://jb.asm.org/content/196/11/2101.abstract] | *'''Michener JK''', Vuilleumier S, Bringel F, and Marx CJ. Phylogeny poorly predicts the utility of a challenging horizontally-transferred gene in ''Methylobacterium'' strains. J Bacteriol. June 2014 196:2101-2107. [http://jb.asm.org/content/196/11/2101.abstract] | ||
*'''Michener JK''', Nielsen J, and Smolke CD. Identification and treatment of heme depletion due to over-expression of a lineage of evolved P450 monooxygenases. PNAS. 2012; 109(47):19504-9. [http://www.pnas.org/content/109/47/19504.abstract] | *'''Michener JK''', Nielsen J, and Smolke CD. Identification and treatment of heme depletion due to over-expression of a lineage of evolved P450 monooxygenases. PNAS. 2012; 109(47):19504-9. [http://www.pnas.org/content/109/47/19504.abstract] |
Revision as of 13:20, 1 August 2014
Josh MichenerEducation
Research Experience
Contact InfoJosh Michener Research InterestsNo gene exists in isolation. To be useful, a gene must be functionally expressed and its host must be able to deal with any resulting stresses. Most genes have had sufficient time in their current host that the gene and host have co-evolved to minimize deleterious interactions. However, while this type of coexistence might be the rule, the exceptions can be both interesting and extremely consequential. When, for example, a microbe acquires new genetic material through horizontal gene transfer or synthetic biology, genes must function in an environment with which they did not co-evolve. Efficient use of a new ability will require careful integration into the existing metabolic and regulatory networks of the host. The interactions between gene and host, as well as their evolutionary outcomes, will determine whether a microbe can become pathogenic, remediate a polluted site, or produce a biofuel. Understanding these interactions and the strategies by which evolution optimizes them will allow us to better anticipate the emergence of new microbial phenotypes. PublicationsResearch Articles
Methods and Reviews
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