Kafatos:George K. Christophides

I am joint head of the Kafatos/Christophides Lab

Imperial faculty webpage

CV

Contact Details

George K. Christophides, PhD
Imperial College London
Division of Cell & Molecular Biology
South Kensington Campus, SAF
London, SW72AZ
UK

Publications

1. Vontas J, Blass C, Koutsos AC, David JP, Kafatos FC, Louis C, Hemingway J, Christophides GK, and Ranson H. Gene expression in insecticide resistant and susceptible Anopheles gambiae strains constitutively or after insecticide exposure. Insect Mol Biol. 2005 Oct;14(5):509-21. DOI:10.1111/j.1365-2583.2005.00582.x |
2. Sim C, Hong YS, Vanlandingham DL, Harker BW, Christophides GK, Kafatos FC, Higgs S, and Collins FH. Modulation of Anopheles gambiae gene expression in response to o'nyong-nyong virus infection. Insect Mol Biol. 2005 Oct;14(5):475-81. DOI:10.1111/j.1365-2583.2005.00578.x |
3. Meister S, Kanzok SM, Zheng XL, Luna C, Li TR, Hoa NT, Clayton JR, White KP, Kafatos FC, Christophides GK, and Zheng L. Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11420-5. DOI:10.1073/pnas.0504950102 |
4. Vlachou D, Schlegelmilch T, Christophides GK, and Kafatos FC. Functional genomic analysis of midgut epithelial responses in Anopheles during Plasmodium invasion. Curr Biol. 2005 Jul 12;15(13):1185-95. DOI:10.1016/j.cub.2005.06.044 |
5. Belyakin SN, Christophides GK, Alekseyenko AA, Kriventseva EV, Belyaeva ES, Nanayev RA, Makunin IV, Kafatos FC, and Zhimulev IF. Genomic analysis of Drosophila chromosome underreplication reveals a link between replication control and transcriptional territories. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8269-74. DOI:10.1073/pnas.0502702102 |
6. Kriventseva EV, Koutsos AC, Blass C, Kafatos FC, Christophides GK, and Zdobnov EM. AnoEST: toward A. gambiae functional genomics. Genome Res. 2005 Jun;15(6):893-9. DOI:10.1101/gr.3756405 |
7. Christophides GK. Transgenic mosquitoes and malaria transmission. Cell Microbiol. 2005 Mar;7(3):325-33. DOI:10.1111/j.1462-5822.2005.00495.x |
8. Hall N, Karras M, Raine JD, Carlton JM, Kooij TW, Berriman M, Florens L, Janssen CS, Pain A, Christophides GK, James K, Rutherford K, Harris B, Harris D, Churcher C, Quail MA, Ormond D, Doggett J, Trueman HE, Mendoza J, Bidwell SL, Rajandream MA, Carucci DJ, Yates JR 3rd, Kafatos FC, Janse CJ, Barrell B, Turner CM, Waters AP, and Sinden RE. A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science. 2005 Jan 7;307(5706):82-6. DOI:10.1126/science.1103717 |
9. Meister S, Koutsos AC, and Christophides GK. The Plasmodium parasite--a 'new' challenge for insect innate immunity. Int J Parasitol. 2004 Dec;34(13-14):1473-82. DOI:10.1016/j.ijpara.2004.10.004 |
10. Osta MA, Christophides GK, Vlachou D, and Kafatos FC. Innate immunity in the malaria vector Anopheles gambiae: comparative and functional genomics. J Exp Biol. 2004 Jul;207(Pt 15):2551-63. DOI:10.1242/jeb.01066 |
11. Christophides GK, Vlachou D, and Kafatos FC. Comparative and functional genomics of the innate immune system in the malaria vector Anopheles gambiae. Immunol Rev. 2004 Apr;198:127-48. DOI:10.1111/j.0105-2896.2004.0127.x |
12. Osta MA, Christophides GK, and Kafatos FC. Effects of mosquito genes on Plasmodium development. Science. 2004 Mar 26;303(5666):2030-2. DOI:10.1126/science.1091789 |
13. Komitopoulou K, Christophides GK, Kalosaka K, Chrysanthis G, Theodoraki MA, Savakis C, Zacharopoulou A, and Mintzas AC. Medfly promoters relevant to the sterile insect technique. Insect Biochem Mol Biol. 2004 Feb;34(2):149-57. DOI:10.1016/j.ibmb.2003.06.016 |
14. Kumar S, Christophides GK, Cantera R, Charles B, Han YS, Meister S, Dimopoulos G, Kafatos FC, and Barillas-Mury C. The role of reactive oxygen species on Plasmodium melanotic encapsulation in Anopheles gambiae. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14139-44. DOI:10.1073/pnas.2036262100 |
15. Christophides GK, Zdobnov E, Barillas-Mury C, Birney E, Blandin S, Blass C, Brey PT, Collins FH, Danielli A, Dimopoulos G, Hetru C, Hoa NT, Hoffmann JA, Kanzok SM, Letunic I, Levashina EA, Loukeris TG, Lycett G, Meister S, Michel K, Moita LF, Müller HM, Osta MA, Paskewitz SM, Reichhart JM, Rzhetsky A, Troxler L, Vernick KD, Vlachou D, Volz J, von Mering C, Xu J, Zheng L, Bork P, and Kafatos FC. Immunity-related genes and gene families in Anopheles gambiae. Science. 2002 Oct 4;298(5591):159-65. DOI:10.1126/science.1077136 |
16. Zdobnov EM, von Mering C, Letunic I, Torrents D, Suyama M, Copley RR, Christophides GK, Thomasova D, Holt RA, Subramanian GM, Mueller HM, Dimopoulos G, Law JH, Wells MA, Birney E, Charlab R, Halpern AL, Kokoza E, Kraft CL, Lai Z, Lewis S, Louis C, Barillas-Mury C, Nusskern D, Rubin GM, Salzberg SL, Sutton GG, Topalis P, Wides R, Wincker P, Yandell M, Collins FH, Ribeiro J, Gelbart WM, Kafatos FC, and Bork P. Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Science. 2002 Oct 4;298(5591):149-59. DOI:10.1126/science.1077061 |
17. Holt RA, Subramanian GM, Halpern A, Sutton GG, Charlab R, Nusskern DR, Wincker P, Clark AG, Ribeiro JM, Wides R, Salzberg SL, Loftus B, Yandell M, Majoros WH, Rusch DB, Lai Z, Kraft CL, Abril JF, Anthouard V, Arensburger P, Atkinson PW, Baden H, de Berardinis V, Baldwin D, Benes V, Biedler J, Blass C, Bolanos R, Boscus D, Barnstead M, Cai S, Center A, Chaturverdi K, Christophides GK, Chrystal MA, Clamp M, Cravchik A, Curwen V, Dana A, Delcher A, Dew I, Evans CA, Flanigan M, Grundschober-Freimoser A, Friedli L, Gu Z, Guan P, Guigo R, Hillenmeyer ME, Hladun SL, Hogan JR, Hong YS, Hoover J, Jaillon O, Ke Z, Kodira C, Kokoza E, Koutsos A, Letunic I, Levitsky A, Liang Y, Lin JJ, Lobo NF, Lopez JR, Malek JA, McIntosh TC, Meister S, Miller J, Mobarry C, Mongin E, Murphy SD, O'Brochta DA, Pfannkoch C, Qi R, Regier MA, Remington K, Shao H, Sharakhova MV, Sitter CD, Shetty J, Smith TJ, Strong R, Sun J, Thomasova D, Ton LQ, Topalis P, Tu Z, Unger MF, Walenz B, Wang A, Wang J, Wang M, Wang X, Woodford KJ, Wortman JR, Wu M, Yao A, Zdobnov EM, Zhang H, Zhao Q, Zhao S, Zhu SC, Zhimulev I, Coluzzi M, della Torre A, Roth CW, Louis C, Kalush F, Mural RJ, Myers EW, Adams MD, Smith HO, Broder S, Gardner MJ, Fraser CM, Birney E, Bork P, Brey PT, Venter JC, Weissenbach J, Kafatos FC, Collins FH, and Hoffman SL. The genome sequence of the malaria mosquito Anopheles gambiae. Science. 2002 Oct 4;298(5591):129-49. DOI:10.1126/science.1076181 |
18. Dimopoulos G, Christophides GK, Meister S, Schultz J, White KP, Barillas-Mury C, and Kafatos FC. Genome expression analysis of Anopheles gambiae: responses to injury, bacterial challenge, and malaria infection. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8814-9. DOI:10.1073/pnas.092274999 |
19. Christophides GK, Savakis C, Mintzas AC, and Komitopoulou K. Expression and function of the Drosophila melanogaster ADH in male Ceratitis capitata adults: a potential strategy for medfly genetic sexing based on gene-transfer technology. Insect Mol Biol. 2001 Jun;10(3):249-54. DOI:10.1046/j.1365-2583.2001.00265.x |
20. Christophides GK, Livadaras I, Savakis C, and Komitopoulou K. Two medfly promoters that have originated by recent gene duplication drive distinct sex, tissue and temporal expression patterns. Genetics. 2000 Sep;156(1):173-82. DOI:10.1093/genetics/156.1.173 |
21. Christophides GK, Mintzas AC, and Komitopoulou K. Organization, evolution and expression of a multigene family encoding putative members of the odourant binding protein family in the medfly Ceratitis capitata. Insect Mol Biol. 2000 Apr;9(2):185-95. DOI:10.1046/j.1365-2583.2000.00176.x |