Kafatos:Habtewold, Tibebu

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Tibebu Habtewold Division of Cell & Molecular Biology South Kensington Campus, SAF London, SW72AZ UK t.habtewold[at]imperial.ac.uk

Medical and Veterinary Entomologist Research Intrest Refractoriness in anopheline mosquitoes against Plasmodium parasites are ancestral virtues. My current research at Imperial College London, involves dissecting genetic causes of refractory mechanism in the cryptic species of An. gambiae complex - Afrotropical mosquitoes consisting malaria vector and non-vector species. I conduct genetic selection of refractory and susceptible lines of mosquitoes, and perform genetic crosses between diriment lines to understand the inheritance of refractory traits. I use microarray/SNP array technology to scan chromosomal region carrying genes conferring refractoriness, and use RNAi technology and proteomic techniques for functional analysis of candidate genes, e.g. depleting of peritrophic membrane genes to see their effect on midgut invasion by Plasmodium parasite. I also conduct studies on the role of midgut microbiota on the Plasmodium invasion and their success to develop into oocysts in susceptible and refractory mosquito species. My research involves the colonization and maintenance of mosquito colonies and infection of female Anopheles with laboratory model rodent malaria parasites (P. berghei) or human malaria parasites (P. falciparum). In the past, I studied interactions between malaria-vectors, humans and livestock in a rural Africa with the aim of developing insecticide treated cattle for integrated vector control interventions applicable to humans and livestock. In the future, I would like to explore the possibilities of using midgut microbiota as vehicles to deliver dsRNA of targeted gene/s as a novel tool to control medically or economically important insects. Education 2000-2004 PhD in Medical and Veterinary Entiomology, the University of Greenwich, NRI, UK 1998/2000 MSc in International Animal Health, University of Edinburgh, CTVM, UK 1988-1893 Doctor of the Degree of Veterinary Medicine, Addis Ababa University, FVM, Ethiopia Publications Habtewold T, Povelones M, Blagborough AM, Christophides GK. Transmission blocking immunity in the malaria non-vector mosquito Anopheles quadriannulatus species A. PLoS Pathog. 2008 May 23;4(5):e1000070. Habtewold T, Prior A, Torr SJ, Gibson G. Could insecticide-treated cattle reduce Afrotropical malaria transmission? Effects of deltamethrin-treated Zebu on Anopheles arabiensis behaviour and survival in Ethiopia. Med Vet Entomol. 2004 Dec;18(4):408-17. Habtewold T, Walker AR, Curtis CF, Osir EO, Thapa N. The feeding behaviour and Plasmodium infection of Anopheles mosquitoes in southern Ethiopia in relation to use of insecticide-treated livestock for malaria control. Trans R Soc Trop Med Hyg. 2001 Nov-Dec;95(6):584-6.