Kafatos:Habtewold, Tibebu: Difference between revisions
| Line 23: | Line 23: | ||
===Medical and Veterinary Entomologist=== | ===Medical and Veterinary Entomologist=== | ||
===Research Intrest=== | ===Research Intrest=== | ||
Refractoriness in anopheline mosquitoes against Plasmodium parasites | Refractoriness in anopheline mosquitoes against Plasmodium parasites are ancestral virtues. My current research at Imperial College London, involves dissecting genetic causes of refractory mechanism in the cryptic species of An. gambiae complex - Afrotropical mosquitoes consisting malaria vector and non-vector species. I carry out genetic selection of refractory and susceptible lines of mosquitoes, and carry out genetic crossing between diriment lines to understand how the refractory traits are inherited. I use microarray/SNP array technology to scan chromosomal region carrying genes conferring refractoriness, and use RNAi technology and proteomic techniques for functional analysis of candidate genes, e.g. depleting of peritrophic membrane genes to see their effect on midgut invasion by Plasmodium parasite. I also conduct studies on the role of midgut microbiota on the Plasmodium invasion and their success to develop into oocyst in susceptible and refractory mosquito species. My researches involve colonising and maintaining mosquito population and infections of female mosquitoes with laboratory model rodent malaria parasites P. berghei or human malaria parasite P. falciparum. In the past, I studied interactions between malaria-vectors, humans and livestock in a typical rural African village with the aim to develop insecticide treated cattle for integrated control of vector born diseases of human and livestock. In the future, I would like to study possibility of using midgut microbiota as vehicles to deliver dsRNA of targeting gene/s as a novel tool to control medically or economically important insects. | ||
===Education=== | ===Education=== | ||
Revision as of 05:00, 18 February 2011
| Click here to visit our NEW WEBSITE |
| The content below is most likely out of date. We also have a new lean and mean openwetware area. |
 |
Tibebu Habtewold Division of Cell & Molecular Biology
|
Medical and Veterinary EntomologistResearch IntrestRefractoriness in anopheline mosquitoes against Plasmodium parasites are ancestral virtues. My current research at Imperial College London, involves dissecting genetic causes of refractory mechanism in the cryptic species of An. gambiae complex - Afrotropical mosquitoes consisting malaria vector and non-vector species. I carry out genetic selection of refractory and susceptible lines of mosquitoes, and carry out genetic crossing between diriment lines to understand how the refractory traits are inherited. I use microarray/SNP array technology to scan chromosomal region carrying genes conferring refractoriness, and use RNAi technology and proteomic techniques for functional analysis of candidate genes, e.g. depleting of peritrophic membrane genes to see their effect on midgut invasion by Plasmodium parasite. I also conduct studies on the role of midgut microbiota on the Plasmodium invasion and their success to develop into oocyst in susceptible and refractory mosquito species. My researches involve colonising and maintaining mosquito population and infections of female mosquitoes with laboratory model rodent malaria parasites P. berghei or human malaria parasite P. falciparum. In the past, I studied interactions between malaria-vectors, humans and livestock in a typical rural African village with the aim to develop insecticide treated cattle for integrated control of vector born diseases of human and livestock. In the future, I would like to study possibility of using midgut microbiota as vehicles to deliver dsRNA of targeting gene/s as a novel tool to control medically or economically important insects. Education
Publications
|
