Kafatos:Habtewold, Tibebu: Difference between revisions

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===Medical and Veterinary Entomologist===
===Medical and Veterinary Entomologist===
===Research Intrest===  
===Research Intrest===  
Natural refractoriness in malaria vector and non-vector mosquitoes is an ancestral virtue.  My research involves dissecting genetic causes of refractoriness in malaria vector and non-vector mosquitoes of Afro-tropical region, An. gambiae complex. I use molecular genetics and proteomic approaches to isolate candidate genes conferring refractoriness, and use RNAi technology for functional the candidate genes, e.g. depleting of peritrophic membrane genes on Anopheles gambiae to determent their effects on midgut invasion by plasmodium parasite.  My researchs involve colonisation and maintaining mosquito population, genetic crossing between different mosquito lines and infections of female mosquitoes with rodent malaria parasites P. berghei or human malaria parasite P. falciparum.  In the past, I had researched on the interactions between malaria-vectors, humans and livestock in a typical rural African village with the aim to develop insecticide treated cattle for integrated control of vector born diseases of human and livestock.  My future research interest is possibility of using symbiotic bacteria as a vehicle to deliver dsRNA of targeting gene/s that affect physiological or vectorial  efficiency of medically or economically important insects.
Refractoriness in anopheline mosquitoes against Plasmodium parasites are ancestral virtues.  My current research at Imperial College London, involves dissecting genetic causes of refractory mechanism in the cryptic species of An. gambiae complex - Afrotropical mosquitoes consisting malaria vector and non-vector species.  I conduct genetic selection of refractory and susceptible lines of mosquitoes, and perform genetic crosses between diriment lines to understand the inheritance of refractory traits. I use microarray/SNP array technology to scan chromosomal region carrying genes conferring refractoriness, and use RNAi technology and proteomic techniques for functional analysis of candidate genes, e.g. depleting of peritrophic membrane genes to see their effect on midgut invasion by Plasmodium parasite.    I also conduct studies on the role of midgut microbiota on the Plasmodium invasion and their success to develop into oocysts in susceptible and refractory mosquito species.  My research involves the colonization and maintenance of mosquito colonies and infection of female Anopheles with laboratory model rodent malaria parasites (P. berghei) or human malaria parasites (P. falciparum).  In the past, I studied interactions between malaria-vectors, humans and livestock in a rural Africa with the aim of developing insecticide treated cattle for integrated vector control interventions applicable to humans and livestock.  In the future, I would like to explore the possibilities of using midgut microbiota as vehicles to deliver dsRNA of targeted gene/s as a novel tool to control medically or economically important insects.
 
 


===Education===  
===Education===  
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* 1998/2000    MSc in International Animal Health, [http://www.ed.ac.uk University of Edinburgh], CTVM, UK
* 1998/2000    MSc in International Animal Health, [http://www.ed.ac.uk University of Edinburgh], CTVM, UK
* 1988-1893    Doctor of the Degree of Veterinary Medicine, [http://www.aau.edu.et Addis Ababa University], FVM, Ethiopia
* 1988-1893    Doctor of the Degree of Veterinary Medicine, [http://www.aau.edu.et Addis Ababa University], FVM, Ethiopia
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===Research Intrest===
Natural refractoriness in malaria vector and non-vector mosquitoes is an ancestral virtue.  My research involves dissecting genetic causes of refractoriness in malaria vector and non-vector mosquitoes of Afro-tropical region, An. gambiae complex.  I use molecular genetics and proteomic approaches to isolate candidate genes conferring refractoriness, and use RNAi technology for functional the candidate genes, e.g. depleting of peritrophic membrane genes on Anopheles gambiae to determent their effects on midgut invasion by plasmodium parasite.  My researchs involve colonisation and maintaining mosquito population, genetic crossing between different mosquito lines and infections of female mosquitoes with rodent malaria parasites P. berghei or human malaria parasite P. falciparum.  In the past, I had researched on the interactions between malaria-vectors, humans and livestock in a typical rural African village with the aim to develop insecticide treated cattle for integrated control of vector born diseases of human and livestock.  My future research interest is possibility of using symbiotic bacteria as a vehicle to deliver dsRNA of targeting gene/s that affect physiological or vectorial  efficiency of medically or economically important insects.


===Publications===
===Publications===

Latest revision as of 07:03, 18 February 2011

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Tibebu Habtewold

Division of Cell & Molecular Biology
South Kensington Campus, SAF
London, SW72AZ
UK


t.habtewold[at]imperial.ac.uk

Medical and Veterinary Entomologist

Research Intrest

Refractoriness in anopheline mosquitoes against Plasmodium parasites are ancestral virtues. My current research at Imperial College London, involves dissecting genetic causes of refractory mechanism in the cryptic species of An. gambiae complex - Afrotropical mosquitoes consisting malaria vector and non-vector species. I conduct genetic selection of refractory and susceptible lines of mosquitoes, and perform genetic crosses between diriment lines to understand the inheritance of refractory traits. I use microarray/SNP array technology to scan chromosomal region carrying genes conferring refractoriness, and use RNAi technology and proteomic techniques for functional analysis of candidate genes, e.g. depleting of peritrophic membrane genes to see their effect on midgut invasion by Plasmodium parasite. I also conduct studies on the role of midgut microbiota on the Plasmodium invasion and their success to develop into oocysts in susceptible and refractory mosquito species. My research involves the colonization and maintenance of mosquito colonies and infection of female Anopheles with laboratory model rodent malaria parasites (P. berghei) or human malaria parasites (P. falciparum). In the past, I studied interactions between malaria-vectors, humans and livestock in a rural Africa with the aim of developing insecticide treated cattle for integrated vector control interventions applicable to humans and livestock. In the future, I would like to explore the possibilities of using midgut microbiota as vehicles to deliver dsRNA of targeted gene/s as a novel tool to control medically or economically important insects.

Education


Publications

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