Kafatos:Lawniczak, Mara: Difference between revisions
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My primary interests revolve around biological interactions that involve antagonistic co-evolution. My Ph.D. was focused on sexual conflict in Drosophila and the molecular basis of male-female interactions. Currently, I am investigating genotype*genotype interactions between Anopheles gambiae mosquito vectors and Plasmodium falciparum parasites. | My primary interests revolve around biological interactions that involve antagonistic co-evolution. My Ph.D. was focused on sexual conflict in Drosophila and the molecular basis of male-female interactions. Currently, I am investigating genotype*genotype interactions between Anopheles gambiae mosquito vectors and Plasmodium falciparum parasites. | ||
In collaboration with Dan Neafsey (Broad Institute), Seth Redmond (Imperial College), and Danny Park (Broad Institute), I have developed an Anopheles gambiae SNP chip that interrogates 400,000 positions across the genome of Anopheles gambiae and 1000 positions across the genome of Plasmodium falciparum. Thus far, we have used the chip to investigate population structure in M, S, and Bamako mosquitoes from Mali. I am co-first author on this work, which will be published in Science in October or November 2010. | In collaboration with Dan Neafsey (Broad Institute), Seth Redmond (Imperial College), and Danny Park (Broad Institute), I have developed an Anopheles gambiae SNP chip that interrogates 400,000 positions across the genome of Anopheles gambiae and 1000 positions across the genome of Plasmodium falciparum. Thus far, we have used the chip to investigate population structure in M, S, and Bamako mosquitoes from Mali. I am co-first author on this work, which will be published in Science in October or November 2010. | ||
We have also used the SNP chip to map variation contributing to the outcome of Plasmodium falciparum, Plasmodium berghei, Beauveria bassiana, Onyongyong virus, and Serratia marcescens infections. This work is actively ongoing and is producing exciting results, identifying both genes we already know to be involved in response to infections and genes we did not know about, opening new avenues of research. | We have also used the SNP chip to map variation contributing to the outcome of Plasmodium falciparum, Plasmodium berghei, Beauveria bassiana, Onyongyong virus, and Serratia marcescens infections. This work is actively ongoing and is producing exciting results, identifying both genes we already know to be involved in response to infections and genes we did not know about, opening new avenues of research. | ||
My main interest in creating the SNP chip is to use this technology to dissect the genetic basis of genotypic interactions between Anopheles mosquitoes and Plasmodium falciparum parasites. Genotype-genotype interactions are incredibly important in determining the outcome of an infection, and we need to gain a handle on the molecular basis of these interactions if we are to make progress towards vector-based strategies of malaria control. | My main interest in creating the SNP chip is to use this technology to dissect the genetic basis of genotypic interactions between Anopheles mosquitoes and Plasmodium falciparum parasites. Genotype-genotype interactions are incredibly important in determining the outcome of an infection, and we need to gain a handle on the molecular basis of these interactions if we are to make progress towards vector-based strategies of malaria control. | ||
I am also interested in the biology and underlying speciation genetics of the Anopheles gambiae incipient species M and S and understanding the genetic basis of the speciation process, in general.I have another co-first author paper in Science coming out in October or November 2010 examining the whole genome sequence data from M and S colonies with respect to this question. It is from these sequences that we identified the 400,000 variable positions which we chose to examine on the SNP chip. | I am also interested in the biology and underlying speciation genetics of the Anopheles gambiae incipient species M and S and understanding the genetic basis of the speciation process, in general.I have another co-first author paper in Science coming out in October or November 2010 examining the whole genome sequence data from M and S colonies with respect to this question. It is from these sequences that we identified the 400,000 variable positions which we chose to examine on the SNP chip. | ||
'''education''' | '''education''' |
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Mara Lawniczak Kafatos/Christophides Lab
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research interests
My primary interests revolve around biological interactions that involve antagonistic co-evolution. My Ph.D. was focused on sexual conflict in Drosophila and the molecular basis of male-female interactions. Currently, I am investigating genotype*genotype interactions between Anopheles gambiae mosquito vectors and Plasmodium falciparum parasites.
In collaboration with Dan Neafsey (Broad Institute), Seth Redmond (Imperial College), and Danny Park (Broad Institute), I have developed an Anopheles gambiae SNP chip that interrogates 400,000 positions across the genome of Anopheles gambiae and 1000 positions across the genome of Plasmodium falciparum. Thus far, we have used the chip to investigate population structure in M, S, and Bamako mosquitoes from Mali. I am co-first author on this work, which will be published in Science in October or November 2010.
We have also used the SNP chip to map variation contributing to the outcome of Plasmodium falciparum, Plasmodium berghei, Beauveria bassiana, Onyongyong virus, and Serratia marcescens infections. This work is actively ongoing and is producing exciting results, identifying both genes we already know to be involved in response to infections and genes we did not know about, opening new avenues of research.
My main interest in creating the SNP chip is to use this technology to dissect the genetic basis of genotypic interactions between Anopheles mosquitoes and Plasmodium falciparum parasites. Genotype-genotype interactions are incredibly important in determining the outcome of an infection, and we need to gain a handle on the molecular basis of these interactions if we are to make progress towards vector-based strategies of malaria control.
I am also interested in the biology and underlying speciation genetics of the Anopheles gambiae incipient species M and S and understanding the genetic basis of the speciation process, in general.I have another co-first author paper in Science coming out in October or November 2010 examining the whole genome sequence data from M and S colonies with respect to this question. It is from these sequences that we identified the 400,000 variable positions which we chose to examine on the SNP chip.
education
University of California, Davis. Ph.D. in Population Biology. 2000- 2004.
Advisor: Dr. David Begun.
University of Texas, Austin. First year Ph.D. program in Integrative Biology. 1999-2000. Advisors: Dr. James Bull & Dr. David Begun.
University of Michigan, Ann Arbor. Bachelor of Science with High Honors in Biology. 1993-1997. Advisors: Dr. Shawn Meagher & Dr. Philip Myers.
interests
evolutionary genetics, sexual conflict, sexual selection, host-parasite antagonistic coevolution, genetic conflict, evolvability, population genetics/genomics, drosophila, anopheles, plasmodium, cephalopods & nepenthes.
previous appointments
University College London. BBSRC funded postdoctoral researcher. 2004- 2006.
Advisor: Dr. Tracey Chapman.
publications
- Bretman A, Lawniczak MK, Boone J, and Chapman T. A mating plug protein reduces early female remating in Drosophila melanogaster. J Insect Physiol. 2010 Jan;56(1):107-13. DOI:10.1016/j.jinsphys.2009.09.010 |
- Lawniczak MK, Holloway AK, Begun DJ, and Jones CD. Genomic analysis of the relationship between gene expression variation and DNA polymorphism in Drosophila simulans. Genome Biol. 2008;9(8):R125. DOI:10.1186/gb-2008-9-8-r125 |
- Holloway AK, Lawniczak MK, Mezey JG, Begun DJ, and Jones CD. Adaptive gene expression divergence inferred from population genomics. PLoS Genet. 2007 Oct;3(10):2007-13. DOI:10.1371/journal.pgen.0030187 |
- Lawniczak MK and Begun DJ. Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster. Mol Biol Evol. 2007 Sep;24(9):1944-51. DOI:10.1093/molbev/msm122 |
- Lawniczak MK, Barnes AI, Linklater JR, Boone JM, Wigby S, and Chapman T. Mating and immunity in invertebrates. Trends Ecol Evol. 2007 Jan;22(1):48-55. DOI:10.1016/j.tree.2006.09.012 |
- Lawniczak MK and Begun DJ. A QTL analysis of female variation contributing to refractoriness and sperm competition in Drosophila melanogaster. Genet Res. 2005 Oct;86(2):107-14. DOI:10.1017/S0016672305007755 |
- Lawniczak MK and Begun DJ. A genome-wide analysis of courting and mating responses in Drosophila melanogaster females. Genome. 2004 Oct;47(5):900-10. DOI:10.1139/g04-050 |