Kafatos:Meister, Stephan

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(The role of PGRP proteins in innate immunity pathways in the malaria vector ''Anopheles gambiae''.)
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====The role of PGRP proteins in innate immunity pathways in the malaria vector ''Anopheles gambiae''.====
====The role of PGRP proteins in innate immunity pathways in the malaria vector ''Anopheles gambiae''.====
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The ''Anopheles gambiae'' peptidoglycan recognition protein (PGRP) gene family consists of 7 genes with 13 PGRP domains. We have analyzed the role of these genes in the mosquito immune defense to bacteria and the malaria parasite ''Plasmodium berghei''.<br><br>
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The ''Anopheles gambiae'' peptidoglycan recognition protein (PGRP) gene family consists of 7 genes with 13 PGRP domains. We analyze the role of these genes in the mosquito immune defense to bacteria and the malaria parasite ''Plasmodium berghei''. We have previously shown that the NF-κB transcription factor REL2 is involved in defense against both types of bacteria and malaria parasites [meister2005]. IMD is only responsible for the reaction against Gram-positive bacteria and ''Plasmodium''. Our data suggests significant divergence as well as many similarities of immune signaling between ''Anopheles gambiae'' and the fruit fly ''Drosophila melanogaster''. The differences most likely reflect the different lifestyles of the two insects and, consequently, different infectious agents that the two insects encounter during their lifetimes. In mosquitoes, one of these agents is the malaria parasite ''Plasmodium''. <br><br>
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Revision as of 08:41, 25 March 2006

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Stephan Meister

Division of Cell & Molecular Biology
South Kensington Campus, SAF
London, SW72AZ
UK

s.meister[at]imperial.ac.uk

I am a PhD student in the Kafatos/Christophides Lab at Imperial College, London.

note: Presently, I'm on the lookout for postdoctoral positions, so if you know of a vacant one in the general areas of either Malaria, Innate Immunity and Signaling - or possibly Marine Biology (one of my more eclectic interest) - by all means, drop me a line. If the research involves high throughput methods and micro arrays, it would be a plus...


Contents

Research Interests

The role of PGRP proteins in innate immunity pathways in the malaria vector Anopheles gambiae.

The Anopheles gambiae peptidoglycan recognition protein (PGRP) gene family consists of 7 genes with 13 PGRP domains. We analyze the role of these genes in the mosquito immune defense to bacteria and the malaria parasite Plasmodium berghei. We have previously shown that the NF-κB transcription factor REL2 is involved in defense against both types of bacteria and malaria parasites [meister2005]. IMD is only responsible for the reaction against Gram-positive bacteria and Plasmodium. Our data suggests significant divergence as well as many similarities of immune signaling between Anopheles gambiae and the fruit fly Drosophila melanogaster. The differences most likely reflect the different lifestyles of the two insects and, consequently, different infectious agents that the two insects encounter during their lifetimes. In mosquitoes, one of these agents is the malaria parasite Plasmodium.

Education


Publications

Error fetching PMID 16076953:
Error fetching PMID 15582524:
Error fetching PMID 14623973:
Error fetching PMID 12364793:
Error fetching PMID 12364791:
Error fetching PMID 12077297:
Error fetching PMID 11516643:
  1. Meister S, PhD Thesis, EMBL/University of Heidelberg, 2006. [phd2006]
  2. Error fetching PMID 16076953: [meister2005]
  3. Error fetching PMID 15582524: [meister2004]
  4. Error fetching PMID 14623973: [kumar2003]
  5. Error fetching PMID 12364793: [christoph2002]
  6. Error fetching PMID 12364791: [holt2002]
  7. Error fetching PMID 12077297: [dimopoulos2002]
  8. Error fetching PMID 11516643: [dunipace2001]
  9. Meister S, Diploma Thesis, University of Wuerzburg, 2001. [Diplom]
All Medline abstracts: PubMed HubMed
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