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Laboratory of Insect Immunogenomics
fourth floor, desk 483
note: Presently, I'm on the lookout for postdoctoral positions, so if you know of a vacant one in the general areas of either malaria, innate immunity and signaling - by all means, drop me a line.
The role of PGRP proteins in innate immunity pathways in the malaria vector Anopheles gambiae.
The Anopheles gambiae peptidoglycan recognition protein (PGRP) gene family consists of 7 genes with 13 PGRP domains. We analyze the role of these genes in the mosquito immune defense to bacteria and the malaria parasite Plasmodium berghei. We have previously shown that the NF-κB transcription factor REL2 is involved in defense against both types of bacteria and malaria parasites . IMD is only responsible for the reaction against Gram-positive bacteria and Plasmodium. Our data suggests significant divergence as well as many similarities of immune signaling between Anopheles gambiae and the fruit fly Drosophila melanogaster. The differences most likely reflect the different lifestyles of the two insects and, consequently, different infectious agents that the two insects encounter during their lifetimes. In mosquitoes, one of these agents is the malaria parasite Plasmodium.
- 2001-present, PhD student, EMBL, Heidelberg, Germany.
- 1999-2000 visiting graduate student at Duke University, NC, USA.
- 1996-2001, Diplom Biol., University of Wuerzburg, Germany.
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- Meister S, PhD Thesis, EMBL/University of Heidelberg, 2006.
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- Meister S, Diploma Thesis, University of Wuerzburg, 2001.