Kafatos:Povelones, Michael: Difference between revisions
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* BA in Chemistry, Columbia University, New York, NY, USA | * BA in Chemistry, Columbia University, New York, NY, USA | ||
* PhD in Developmental Biology, Stanford University, Stanford, CA, USA | * PhD in Developmental Biology, Stanford University, Stanford, CA, USA | ||
* Biology of Parasitism 2005, MBL, Woods Hole, MA | * Biology of Parasitism 2005, MBL, Woods Hole, MA | ||
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Revision as of 14:23, 19 August 2006
Michael Povelones Division of Cell & Molecular Biology |
Education
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Current Research InterestsI am a postdoctoral fellow in the Kafatos/Christophides Lab at Imperial College, London. Science is cool. |
Previous ResearchI received my doctoral degree at Stanford University in the laboratory of Roel Nusse. The focus of my research was understanding how the frizzled (fz) receptor in Drosophila functions in planar cell polarization (PCP) and Wnt-mediated cell fate specification. fz controls two different signal transduction pathways for each of these distinct developmental outcomes. How does a single receptor function in two signaling pathways? This work revealed that even though cell fate signaling requires a Wnt ligand, fz is not activated by any of the 7 Drosophila Wnt genes for its PCP function. Instead, fz has an intrinsic ability to control components of the PCP pathway and that it associates with pathway specific Wnt co-receptor for cell fate signaling. In addition, a structure-function analysis of fz suggested that, in addition to the Wnt binding site located in the extracellular cysteine-rich domain, there is a second Wnt-binding site within the transmembrane portion of the receptor.
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