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| {{Kafatos/Christophides Lab-Small-Blue}}
| | http://www.vet.upenn.edu/people/faculty-clinician-search/MICHAELPOVELONES |
| {|cellspacing="5" cellpadding="10" style="background:#ffffff; width: 500px;"
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| [[Image:Kafatos-action-pove.jpg|left|200px]]
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| <div style="padding: 10px; color: #ffffff; background-color: #3674C2; width: 300px">
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| <font size="5">'''Michael Povelones'''</font size>
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| </div> <BR>
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| <div style="padding: 10px; color: #ffffff; background-color: #3674C2; width: 300px">
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| <font size="3" color="#ffffff">Division of Cell & Molecular Biology<br>
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| Imperial College<br>
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| South Kensington Campus<br>
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| SAF Building<br>
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| London, SW7 2AZ<br>
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| United Kingdom<br>
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| </font size></div>
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| __NOTOC__
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| ==Education==
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| BA in Chemistry, Columbia University, New York, NY, USA<br>
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| PhD in Developmental Biology, Stanford University, Stanford, CA, USA<br>
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| Biology of Parasitism 2005, MBL, Woods Hole, MA<br>
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| ==Current Research Interests==
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| I am a postdoctoral fellow in the [[kafatos:Kafatos/Christophides Lab|Kafatos/Christophides Lab]] at [http://www.imperial.ac.uk/ Imperial College], London. Science is cool.
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| ==Previous Research==
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| [[Image:Kafatos-pove-fz.png|right|130px]]
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| I received my doctoral degree at Stanford University in the laboratory of Roel Nusse. The focus of my research was understanding how the ''frizzled (fz)'' receptor in ''Drosophila'' functions in planar cell polarization (PCP) and Wnt-mediated cell fate specification. ''fz'' controls two different signal transduction pathways for each of these distinct developmental outcomes. How does a single receptor function in two signaling pathways? This work revealed that even though cell fate signaling requires a Wnt ligand, ''fz'' is not activated by any of the 7 ''Drosophila'' Wnt genes for its PCP function. Instead, ''fz'' has an intrinsic ability to control components of the PCP pathway and that it associates with pathway specific Wnt co-receptor for cell fate signaling. In addition, a structure-function analysis of ''fz'' suggested that, in addition to the Wnt binding site located in the extracellular cysteine-rich domain, there is a second Wnt-binding site within the transmembrane portion of the receptor.
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| <div style="padding: 10px; color: #222222; background-color: #eeeeee; width: 500px">
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| <biblio>
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| #embo2005 pmid=16163385
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| #genetics2005 pmid=16085697
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| #naturecellbio2002 pmid=12415278
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| </biblio>
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| </div>
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| == Publications ==
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| <biblio>
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| #embo2005 pmid=16163385
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| #genetics2005 pmid=16085697
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| #naturecellbio2002 pmid=12415278
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| #neurobiology2001a pmid=11257614
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| #neurobiology2001b pmid=11153011
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| #neuroscience1997 pmid=9185529
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| #neuroscience1996 pmid=8922402
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| </biblio>
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