Kafatos:Retreat: Difference between revisions
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====1. High throughput genetic screens in the mosquito==== | ====1. High throughput genetic screens in the mosquito==== | ||
*a. Genome-wide RNAi: | *a. Genome-wide RNAi: | ||
:: | ::George Christophides (Kafatos/Christophides) | ||
*b. Mutagenesis: | *b. Mutagenesis: | ||
Revision as of 04:08, 11 March 2006
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date & location
16th&17th of March @ the Wye Campus
Signup Status:
Session I: Working groups on novel approaches to malaria control
1. Vaccines
- a. Target Identification:
- Julian Gray (Crisanti), Andrew Blagborough (Sinden)
- b. Transmission blocking:
- Ellen Runn(Kafatos/Christophides), Kalpana Lal (Sinden), Rebecca Stanway (Sinden), Souraya Ramjanee(Sinden), Anastasios Koutsos (Kafatos/Christophides)
2. Transgenic mosquitoes
- a. Sterile Insect Technique:
- Jason Benton (Crisanti), Gianmaria Liccardi (Crisanti), Kristin Michel (Kafatos), Lietta Nicolaides (Crisanti)
- b. Resistance genes:
- Stephan Meister (Kafatos/Christophides), Idir Akhouayri (Billker)
- c. Drive mechanisms:
- Philippos Papathanos (Crisanti)
3. Chemical approaches to transmission control
- a. Smart sprays to target innate immunity:
- Tibebu Habtewold (Kafatos/Christophides)
- b. Insecticides and insecticide resistance:
- Hilary Ranson (Crisanti)
- c. Transmission blocking inhibitors:
- Andreas Raabe (Billker), Rob (Billker)
Session II: Vector-parasite genome interactions (presentations)
1. High throughput genetic screens in the mosquito
- a. Genome-wide RNAi:
- George Christophides (Kafatos/Christophides)
- b. Mutagenesis:
- Nikolai Windbichler (Crisanti),
2. Identification of gene function
- a. Microarrays analysis in mosquitoes:
- Kalle Magnusson (Crisanti), Tibebu Habtewold (Kafatos/Christophides)
- b. Knockout screens in the parasite:
- Ellen Runn (Kafatos/Christophides), Andrea Ecker (Sinden),Rita Tewari (Sinden), Robert Moon (Sinden)
- c. Inducible KO technologies:
- Paco Pino (Billker)
- d. Protein-protein interactions:
- Chandra Ramakrishnan (Sinden), Anastasios Koutsos (Kafatos/Christophides)
Session III: Model systems and their appropriateness
- a. A. gambiae - P. berghei system:
- b. Differences and similarities between plasmodia:
- Jacqui Mendoza (Sinden), Geoff Butcher (Sinden)
- c. A. stephensi:
Reporting
- Stephan Meister(Kafatos/Christophides)
Participants and email addresses by lab:
<showhide>
Crisanti Lab:
__HIDER__
<hide>
| Name | coming? | |
| Andrea Crisanti | a.drcrisanti@imperial.ac.uk | ? |
| Flaminia Cattericcia | f.catteruccia@imperial.ac.uk | yes |
| Jason Benton | jason.benton@imperial.ac.uk | yes |
| Philippos Papathanos | p.papathanos@imperial.ac.uk | yes |
| Hilary Ranson | Hranson@liverpool.ac.uk | yes |
| Nikolai Windbichler | nikiwind@gmx.at | yes |
| Kalle Magnusson | kalle.magnusson@imperial.ac.uk | yes |
| Julian Gray | julian.gray@imperial.ac.uk | yes |
| Tania Dottorini | dottorin@unipg.it | yes |
| Lietta Nicolaides | lietta.nicolaides@gmail.com | yes |
| Gianmaria Liccardi | gianmaria_liccardi@yahoo.it | yes |
| Giorgio Mazzoleni | giorgiomazzoleni@aliceposta.it | yes |
| Elena Mangia | e.mangia@imperial.ac.uk | yes |
| Rebecca Armson | rebecca.armson@imperial.ac.uk | yes |
</hide></showhide>
<showhide>
Kafatos/Christophides Lab:
__HIDER__
<hide>
| Name | coming? | |
| Fotis Kafatos | f.kafatos@imperial.ac.uk | ? |
| George Christophides | g.christophides@imperial.ac.uk | yes |
| Dina Vlachou | d.vlachou@imperial.ac.uk | yes |
| Kristin Michel | k.michel@imperial.ac.uk | yes |
| Timm Schlegelmilch | timm.schlegelmilch@imperial.ac.uk | yes |
| Stephan Meister | s.meister@imperial.ac.uk | yes |
| Mike Osta | osta@embl.de | yes, not o/n |
| Ellen Runn | ellen.runn@imperial.ac.uk | yes |
| Anna Schnitger | a.schnitger@imperial.ac.uk | yes |
| Antonio Mendes | antonio.mendes@imperial.ac.uk | yes |
| Anastasios Koutsos | a.koutsos@imperial.ac.uk | yes |
| Tibebu Habtewold | t.habtewold@imperial.ac.uk | yes |
| Michael Povelones | m.povelones@imperial.ac.uk | yes |
| Seth Redmond | seth.redmond@imperial.ac.uk | ? |
| Joanna Waldock | joanna.waldock@imperial.ac.uk | No |
| Robert Waterhouse | No | |
| Stephanie Jaubert | Stephanie.Jaubert@rennes.inra.fr | No |
| Bob MacCallum | r.maccallum@imperial.ac.uk | Could do either day but not o/n |
</hide></showhide>
<showhide>
Sinden Lab:
__HIDER__
<hide>
| Name | coming? | |
| Bob Sinden | r.sinden@imperial.ac.uk | Yes |
| Geoffrey Butcher | geoffrey.butcher@virgin.net | ? |
| Kalpana Lal | kalpana.lal@imperial.ac.uk | Yes |
| Andrew Blagborough | a.blagborough@imperial.ac.uk | Yes |
| Andrea Ecker | andrea.ecker@imperial.ac.uk | Yes |
| Ken Baker | k.baker@imperial.ac.uk | Yes |
| Jacqueline Mendoza | j.mendoza@imperial.ac.uk | Yes |
| Chandra Ramakrishnan | c.ramakrishnan@imperial.ac.uk | Yes |
| Marta Tufet Bayona | marta.tufet-bayona@imperial.ac.uk | Yes |
| Souraya Ramjanee | souraya.ramjanee@imperial.ac.uk | Yes |
| Rebecca Stanway | rebecca.stanway@imperial.ac.uk | Yes |
</hide></showhide>
<showhide>
Billker Lab:
__HIDER__
<hide>
| Name | coming? | |
| Oliver Billker | o.billker@ic.ac.uk | Yes |
| Rita Tewari | r.tewari@imperial.ac.uk | Yes |
| Paco Pino | p.pino@imperial.ac.uk | Yes |
| Robert Moon | robert.moon@imperial.ac.uk | Yes |
| Idir Akhouayri | i.akhouayri@imperial.ac.uk | Yes |
| Andreas Raabe | ac.raabe@imperial.ac.uk | Yes |
| Gerald Wenig | g.wenig@imperial.ac.uk | No |
| Bec Schepers | r.schepers@imperial.ac.uk | Yes |
</hide></showhide>
preliminary Program
16th March 2006, Thursday
<showhide>
Program for the day
__HIDER__
<hide>
11:00 - 12:30 Introduction and PI presentations
12:30 - 14:00 Lunch break
14:00 - 16:00 Round table discussion
16:00 - 16:30 Coffee break
16:30 - 18:00 Session I: Novel approaches to malaria control 1
18:00 - 18:15 Coffee break
18:15 - 19:30 Session I: Novel approaches to malaria control 2
20:00 - 21:30 Dinner
21:30 - XXXX Drink and mixing
PI presentations (15 min each maximum)
Round table discussion
- The discussion aims to identify what needs to be done to achieve the aims of the meeting, to involve all people present and prepare the meeting to become a forum for discussion and not a sterile scientific meeting. It could be also organized into working groups (with short presentations).
Session I: Working groups on novel approaches to malaria control
- People from different groups will work together to present the state-of-the-art on the following approaches. Presentations will be short (10min), each followed by discussion aiming to highlight the feasibility of each approach. Approaches selected to be presented are representative of the research in each group, thus is expected to identify the work of the group in these areas.
- 1. Vaccines
- a. Target identification
- b. Transmission blocking
- 1. Vaccines
- 2. Transgenic mosquitoes
- a. Sterile Insect Technique
- b. Resistance genes
- c. Drive mechanisms
- 2. Transgenic mosquitoes
- 3. Drug development
- Prioritization of drug targets / IC Pharma
- 3. Drug development
- 4. Chemical approaches to transmission control
- a. Smart sprays to target innate immunity
- b. Insecticides and insecticide resistance
- c. Transmission blocking inhibitors
- 4. Chemical approaches to transmission control
</hide></showhide>
17th March 2006, Friday
<showhide>
Program for the day
__HIDER__
<hide>
08:30 - 09:45 Session II: Vector-parasite genome interactions (presentations)
09:45 - 10:15 Coffee break
10:15 - 11:15 Session III: Discussion on technological challenges
11:15 - 12:30 Session IV: Model systems and their appropriateness
12:30 - 14:00 Lunch break
14:00 - 16:00 Walk and interaction
16:00 - 16:30 Session V: Summarize the outcomes of the meeting
Session II: Presentations on vector-parasite genome interactions
- Presentation from nominated people or groups of people aiming to identify technologies and expertise that are currently available among participating groups (and can be made available to others, thus promoting collaboration between groups), identify those that need to be developed/introduced, and probe the discussions of Session III. The presentations will be followed by short time for questions (not discussion).
- 1. High throughput genetic screens in the mosquito
- a. Genome-wide RNAi
- b. Mutagenesis
- 1. High throughput genetic screens in the mosquito
- 2. Identification of gene function
- a. Microarrays analysis in mosquitoes
- b. Knockout screens in the parasite
- c. Inducible KO technologies in vectors and
- 2. Identification of gene function
Session III: Discussion on technological challenges
- Aims to identify what needs to be done to increase our competence in the areas presented above and in new areas that we may want to expand/exploit in the future. The discussion would be mostly around technology and expertise.
- Functional genomics and screens for parasites and mosquitoes
- Array technologies to characterize parasite mutants
Session IV: Model systems and appropriateness
- Aims to discuss the pros and cons of using model systems and identify ways to maximize the relevance of our research to the transmission of human diseases
- 1. A. gambiae - P. berghei
- 2. Differences and similarities between plasmodia
- 3. A. stephensi
Session V: Summarize the outcomes of the meeting
- Two people nominated as the reporters of the meeting will summarize what it was presented and discussed throughout these two days, with the aim to identify what the meeting has achieved in regards to its initial aims. A full report can be produced within the next days.
</hide></showhide>
