Kafatos:Retreat

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16th & 17th of March @ the Wye Campus:

• catch the 9:53 am train from Charing Cross Station. The train will arrive at Wye at 11:07. It is a 15 min walk from the station to the campus. We will then start our first session at 11:30, which is slightly later than originally planned.
  

• We couldn't purchase tickets in advance, so please allow enough time to buy these yourselves.

• Remember to keep the tickets for reimbursement.

• Most of us will return the next day and should buy a NETWORK AWAY BREAK (£20.80). If you need to return to London the same evening, buy a CHEAP DAY RETURN (£17.60). (Avoid buying single tickets at £15.40 each way.)

• Those of you travelling by car can get instructions here.

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Signup Status:

Session I: Working groups on novel approaches to malaria control

1. Vaccines

• a. Target Identification (20 min):

Julian Gray (Crisanti), Andrew Blagborough (Sinden)

• b. Transmission blocking (30 min):

Ellen Runn(Kafatos/Christophides), Kalpana Lal (Sinden), Rebecca Stanway (Sinden), Souraya Ramjanee(Sinden), Anastasios Koutsos (Kafatos/Christophides)

2. Transgenic mosquitoes (55 min)

• a. Sterile Insect Technique:

Jason Benton (Crisanti), Gianmaria Liccardi (Crisanti), Kristin Michel (Kafatos), Lietta Nicolaides (Crisanti), Flaminia Catteruccia (Crisanti)

• b. Resistance genes:

Stephan Meister (Kafatos/Christophides), Idir Akhouayri (Billker)

• c. Drive mechanisms:

Philippos Papathanos (Crisanti)

3. Chemical approaches to transmission control

• a. Insecticides and insecticide resistance:

Hilary Ranson (Crisanti)

• b. Smart sprays and transmission blocking inhibitors:

Andreas Raabe (Billker), Rob Moon(Billker), Tibebu Habtewold (Kafatos/Christophides)

Session II: Vector-parasite genome interactions (presentations)

1. High throughput genetic screens in the mosquito

• a. Genome-wide RNAi:

George Christophides (Kafatos/Christophides), Timm Schlegelmilch (Kafatos/Christophides)

• b. Mutagenesis:

Nikolai Windbichler (Crisanti),

2. Identification of gene function

• a. Microarrays analysis in mosquitoes:

Kalle Magnusson (Crisanti), Tibebu Habtewold (Kafatos/Christophides), Dina Vlachou (Kafatos/Christophides), Antonio Mendes (Kafatos/Christophides)

• b. Knockout screens in the parasite:

Ellen Runn (Kafatos/Christophides), Andrea Ecker (Sinden),Rita Tewari (Sinden)

• c. Inducible KO technologies:

Paco Pino (Billker)

• d. Protein-protein interactions:

Chandra Ramakrishnan (Sinden), Anastasios Koutsos (Kafatos/Christophides), Mike Osta (K/C), Marta Tufet (Sinden)

Session III: Model systems and their appropriateness

• a. A. gambiae - P. berghei system:

Dina Vlachou (Kafatos/Christophides), Antonio Mendes (Kafatos/Christophides), Mike Osta (K/C)

• b. Differences and similarities between plasmodia:

Jacqui Mendoza (Sinden), Geoff Butcher (Sinden)

Reporting

Stephan Meister(Kafatos/Christophides), Nikolai Windbichler (Crisanti),Kalpana Lal (Sinden)

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Participants and email addresses by lab:

<showhide> Crisanti Lab: __HIDER__
<hide>

Name	email	coming?	signed up?
Andrea Crisanti	a.drcrisanti@imperial.ac.uk	?	-
Flaminia Catteruccia	f.catteruccia@imperial.ac.uk	yes	1x
Jason Benton	jason.benton@imperial.ac.uk	yes	1x
Philippos Papathanos	p.papathanos@imperial.ac.uk	yes	1x
Hilary Ranson	Hranson@liverpool.ac.uk	yes	1x
Nikolai Windbichler	nikiwind@gmx.at	yes	1x
Kalle Magnusson	kalle.magnusson@imperial.ac.uk	yes	1x
Julian Gray	julian.gray@imperial.ac.uk	yes	1x
Tania Dottorini	dottorin@unipg.it	yes	-
Lietta Nicolaides	lietta.nicolaides@gmail.com	yes	1x
Gianmaria Liccardi	gianmaria_liccardi@yahoo.it	yes	1x
Giorgio Mazzoleni	giorgiomazzoleni@aliceposta.it	yes	-
Elena Mangia	e.mangia@imperial.ac.uk	yes	-
Rebecca Armson	rebecca.armson@imperial.ac.uk	yes	-

</hide></showhide> <showhide> Kafatos/Christophides Lab: __HIDER__
<hide>

Name	email	coming?	signed up?
Fotis Kafatos	f.kafatos@imperial.ac.uk	no	-
George Christophides	g.christophides@imperial.ac.uk	yes	1x
Dina Vlachou	d.vlachou@imperial.ac.uk	yes	2x
Kristin Michel	k.michel@imperial.ac.uk	yes	1x
Timm Schlegelmilch	timm.schlegelmilch@imperial.ac.uk	yes	1x
Stephan Meister	s.meister@imperial.ac.uk	yes	2x
Mike Osta	osta@embl.de	yes, not o/n	1x
Ellen Runn	ellen.runn@imperial.ac.uk	yes	2x
Anna Schnitger	a.schnitger@imperial.ac.uk	yes	-
Antonio Mendes	antonio.mendes@imperial.ac.uk	yes	2x
Anastasios Koutsos	a.koutsos@imperial.ac.uk	yes	2x
Tibebu Habtewold	t.habtewold@imperial.ac.uk	yes	2x
Michael Povelones	m.povelones@imperial.ac.uk	yes	-
Seth Redmond	seth.redmond@imperial.ac.uk	thurs	-
Joanna Waldock	joanna.waldock@imperial.ac.uk	No	-
Robert Waterhouse	robert.waterhouse@imperial.ac.uk	No	-
Stephanie Jaubert	Stephanie.Jaubert@rennes.inra.fr	No	-
Bob MacCallum	r.maccallum@imperial.ac.uk	No	-
Sofia Pinto	s.pinto@imperial.ac.uk	no	-

</hide></showhide> <showhide> Sinden Lab: __HIDER__
<hide>

Name	email	coming?	signed up?
Bob Sinden	r.sinden@imperial.ac.uk	Yes	-
Geoffrey Butcher	geoffrey.butcher@virgin.net	?	1x
Kalpana Lal	kalpana.lal@imperial.ac.uk	Yes	1x
Andrew Blagborough	a.blagborough@imperial.ac.uk	Yes	1x
Andrea Ecker	andrea.ecker@imperial.ac.uk	Yes	1x
Ken Baker	k.baker@imperial.ac.uk	Yes	-
Jacqueline Mendoza	j.mendoza@imperial.ac.uk	Yes	1x
Chandra Ramakrishnan	c.ramakrishnan@imperial.ac.uk	Yes	1x
Marta Tufet Bayona	marta.tufet-bayona@imperial.ac.uk	Yes	1x
Souraya Ramjanee	souraya.ramjanee@imperial.ac.uk	Yes	1x
Rebecca Stanway	rebecca.stanway@imperial.ac.uk	Yes	1x

</hide></showhide> <showhide> Billker Lab: __HIDER__
<hide>

Name	email	coming?	signed up?
Oliver Billker	o.billker@ic.ac.uk	Yes	-
Rita Tewari	r.tewari@imperial.ac.uk	Yes	1x
Paco Pino	p.pino@imperial.ac.uk	Yes	1x
Robert Moon	robert.moon@imperial.ac.uk	Yes	1x
Idir Akhouayri	i.akhouayri@imperial.ac.uk	Yes	1x
Andreas Raabe	ac.raabe@imperial.ac.uk	Yes	1x
Gerald Wenig	g.wenig@imperial.ac.uk	No	-
Bec Schepers	r.schepers@imperial.ac.uk	Yes	-

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preliminary Program

16th March 2006, Thursday

<showhide> Program for the day __HIDER__
<hide> 12:00 - 13:00 Introduction and PI presentations

13:00 - 14:30 Lunch break and check-in

14:30 - 16:00 Round table discussion

16:00 - 16:30 Coffee break

16:30 - 17:45 Session I: Novel approaches to malaria control 1

17:45 - 18:00 Coffee break

18:00 - 19:30 Session I: Novel approaches to malaria control 2

20:00 - 21:30 Dinner

21:30 - Mixer

PI presentations (15 min each maximum)

Round table discussion

The discussion aims to identify what needs to be done to achieve the aims of the meeting, to involve all people present and prepare the meeting to become a forum for discussion and not a sterile scientific meeting. It could be also organized into working groups (with short presentations).

Session I: Working groups on novel approaches to malaria control

People from different groups will work together to present the state-of-the-art on the following approaches. Presentations will be short (10min), each followed by discussion aiming to highlight the feasibility of each approach. Approaches selected to be presented are representative of the research in each group, thus is expected to identify the work of the group in these areas.

1. Vaccines

a. Target identification

b. Transmission blocking

2. Transgenic mosquitoes

a. Sterile Insect Technique

b. Resistance genes

c. Drive mechanisms

3. Drug development

Prioritization of drug targets / IC Pharma

4. Chemical approaches to transmission control

a. Smart sprays to target innate immunity

b. Insecticides and insecticide resistance

c. Transmission blocking inhibitors

</hide></showhide>

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17th March 2006, Friday

<showhide> Program for the day __HIDER__
<hide> 08:30 - 09:45 Session II: Vector-parasite genome interactions (presentations)

09:45 - 10:15 Coffee break

10:15 - 11:15 Session III: Discussion on technological challenges

11:15 - 12:30 Session IV: Model systems and their appropriateness

12:30 - 14:00 Lunch break

14:00 - 16:00 Walk and interaction

16:00 - 16:30 Session V: Summarize the outcomes of the meeting

Session II: Presentations on vector-parasite genome interactions

Presentation from nominated people or groups of people aiming to identify technologies and expertise that are currently available among participating groups (and can be made available to others, thus promoting collaboration between groups), identify those that need to be developed/introduced, and probe the discussions of Session III. The presentations will be followed by short time for questions (not discussion).

1. High throughput genetic screens in the mosquito

a. Genome-wide RNAi

b. Mutagenesis

2. Identification of gene function

a. Microarrays analysis in mosquitoes

b. Knockout screens in the parasite

c. Inducible KO technologies in vectors

d. Protein-protein interactions

Session III: Discussion on technological challenges

Aims to identify what needs to be done to increase our competence in the areas presented above and in new areas that we may want to expand/exploit in the future. The discussion would be mostly around technology and expertise.

• Functional genomics and screens for parasites and mosquitoes
• Array technologies to characterize parasite mutants

Session IV: Model systems and appropriateness

Aims to discuss the pros and cons of using model systems and identify ways to maximize the relevance of our research to the transmission of human diseases

1. A. gambiae - P. berghei

2. Differences and similarities between plasmodia

3. A. stephensi

Session V: Summarize the outcomes of the meeting

Two people nominated as the reporters of the meeting will summarize what it was presented and discussed throughout these two days, with the aim to identify what the meeting has achieved in regards to its initial aims. A full report can be produced within the next days.

</hide></showhide>