Kafatos:Vlachou, Dina

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#In-Press Bushell E. S., Schlegelmilch T., Ecker A., Goulding D., Sinden R. E., Christophides G. K., Kafatos F. C., Vlachou D. (2009) Paternal Effect of the Nuclear Formin-like Protein MISFIT on Plasmodium Development in the Mosquito Vector. PLoS Pathogens.
#baum2009 pmid=19380379
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#mendes2008 pmid=18483558
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Dina Vlachou

Division of Cell and Molecular Biology
Faculty of Natural Sciences
Imperial College London
Sir Alexander Fleming Building
South Kensington Campus
SW7 2AZ
London
United Kingdom

Tel.: +44 20 759 42031
Fax: +44 20 759 41759
Email: d.vlachou@imperial.ac.uk

Senior Research Scientist at Imperial College, London
.


1997: Ph.D. in Molecular Biology and Evolution, University of Athens, Greece

Contents

Professional profile

1990-1991: Research assistant, Division of Genetic and Biotechnology, Department of Biology, University of Athens, Greece. Postgraduate research in insect molecular biology.
1991-1997: PhD studies, Division of Genetic and Biotechnology, Department of Biology, University of Athens, Greece. Research Area: Functional and evolutionary analysis of chorion genes in Diptera.
1997-2000: Post-doctoral fellow, Institute of Molecular Biology and Biotechnology/Foundation for Research and Technology (IMBB/FORTH), Crete, Greece. Research Area: Identification of Anopheles gambiae midgut proteins putatively interacting with Plasmodium surface proteins.
2000-2001: RTN Post-doctoral fellow, Department of Parasitology, University of Leiden (LUMC), Leiden, The Netherlands. Research Area: Genetic manipulation of Plasmodium berghei and development of alternative tools for conditional knockout and transient expression of genes in the parasite mosquito stages.
2001-2003: Marie Curie Research Fellow, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. Research Area: Molecular and cellular dissection of mosquito midgut invasion, and mosquito immune responses.
2003-2005: Senior Research Associate, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. Research Area: Molecular and cellular dissection of mosquito midgut invasion, and mosquito immune responses.
2005-present: Senior Research Scientist, Division of Cell and Molecular Biology, Imperial College London, United Kingdom. Research Area: Functional genomics of mosquito/parasite interactions.

Research Interests

My scientific interests lie in the field of infectious diseases, especially malaria, a leading parasitic disease transmitted by Anopheles mosquitoes. It affects half of the global population and kills 1-3 million people every year, the vast majority children aged below 5 in sub-Saharan Africa. My research focuses on the understanding of molecular and cellular interactions between Anopheles mosquitoes and malaria parasites, Plasmodium, using functional genomics and emphasizing on mosquito midgut infection, the most critical stage in the malaria transmission cycle. It utilizes both laboratory model transmission systems, i.e. Anopheles mosquitoes and rodent parasites Plasmodium berghei, and naturally interacting populations of Anopheles gambiae and human parasites Plasmodium falciparum. Detail understanding of parasite/mosquito interactions may guide development of novel control strategies to control the disease.

Current research projects:
Functional genomic dissection of the Anopheles gambiae tissue responses to Plasmodium developmental stages
Comparative genomic analysis of the mosquito responses to the rodent parasite Plasmodium berghei and the human parasite Plasmodium falciparum in natural transmission conditions in Africa
Molecular and cell biological analysis of Plasmodium migration through the mosquito midgut
Monitoring of the sporogonic developmental transcriptome of Plasmodium berghei and its interaction with the mosquito transcriptome

Distinctions and Awards

• PhD individual fellowship by Academy of Athens, Greece (1993-1996)
• Marie-Curie Individual Research Fellowship, European Commission, Fifth Framework Program (2001-2003)

International profile

• Invited speaker at Host Response to Cell Invasion Workshop, The 11th Annual and International Congress of Parasitology (ICOPA XI), hosted by the British Society for Parasitology, Glasgow, 6-11 August 2006
• Invited speaker at 17th International Biology of Disease Vectors Course, University of Liverpool, Liverpool, England U.K, 16-28 July 2006
• Invited speaker at 2nd Annual International BioMalPar Conference, Heidelberg, Germany, May 2006

National and international collaborations include Prof Robert E. Sinden (Imperial College), Dr Chris Janse (University of Leiden), Dr Isabelle Morlais (Institute of Research and Development(IRD)/OCEAC, Cameroon), Dr Anna Cohuet (IRD, Montpellier), Dr Didier Fontenille (IRD, Montpellier) and Dr Herwig Schüler (Karolinska University).

[Click to see press release]

Academic profile

Teaching assistantship of pre-graduated students at the Departments of Biology and Pharmacology, University of Athens, Greece (1991-1996)
Invited lecturer at postgraduate student course in Bioinformatics, University of Athens, Greece (May 2005)
Invited lecturer at 17th International Annual Biology of Disease Vectors Course (BDV), University of Liverpool, Liverpool, UK (16-28 July 2006)
Project leader and Thesis supervisor of Imperial College PhD candidates Timm Schlegelmilch, Ellen Bushell and Karolina Akinosoglou
Project leader and Thesis supervisor of BioMalPar International PhD Programme fellow Antonio Mendes
Thesis advisor of PhD candidate Caroline Harris (University of Montpellier, France)
Supervisor of final year project of Imperial College pre-graduate students (2007)
Examiner of final year project vivas of Imperial College pre-graduate students (2006, 2007)

Publications

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  1. Bushell E. S., Schlegelmilch T., Ecker A., Goulding D., Sinden R. E., Christophides G. K., Kafatos F. C., Vlachou D. (2009) Paternal Effect of the Nuclear Formin-like Protein MISFIT on Plasmodium Development in the Mosquito Vector. PLoS Pathogens. [In-Press]
  2. Error fetching PMID 19380379: [baum2009]
  3. Error fetching PMID 18483558: [mendes2008]
  4. Error fetching PMID 17588928: [waterhouse2007]
  5. Error fetching PMID 16793259: [vlachou2006]
  6. Error fetching PMID 16005290: [vlachou2005]
  7. Error fetching PMID 15996894: [vlachou2005b]
  8. Error fetching PMID 15201288: [osta2004]
  9. Error fetching PMID 15199960: [christophides2004]
  10. Error fetching PMID 15186403: [vlachou2004]
  11. Error fetching PMID 12828632: [dessens2003]
  12. Error fetching PMID 12364793: [christophides2002]
  13. Error fetching PMID 11404001: [vlachou2001]
  14. Error fetching PMID 11223130: [vlachou2001b]
  15. Error fetching PMID 11163454: [margos2000]
  16. Error fetching PMID 10984433: [sinden-kiamos]
  17. Error fetching PMID 9409839: [vlachou1997]
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